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Odorless Garlic Extract

Also known as: Odorless garlic, Aged garlic extract (AGE), Fermented garlic, Garlic extract, Allium sativum (Odorless Garlic Extract)

Overview

Odorless garlic extract is a derivative of garlic (*Allium sativum*) processed to minimize its characteristic odor while retaining its bioactive compounds. It is created through aging or fermentation processes, which reduce the allicin content and increase the concentration of more stable compounds like S-allyl-cysteine. Primarily, it is used for its potential cardiovascular benefits, including reducing blood pressure and improving cholesterol levels, as well as for its antioxidant properties. Research suggests that odorless garlic extract may offer a more palatable way to obtain the health benefits associated with garlic, though the evidence is still evolving. It is available in various forms, including capsules, tablets, and liquid extracts, and is often marketed as a dietary supplement for heart health and overall wellness. The quality of available evidence is moderate, with ongoing studies aimed at confirming its long-term effectiveness and optimal usage.

Benefits

Odorless garlic extract has shown potential benefits, particularly in cardiovascular health. A meta-analysis indicated that garlic preparations, including odorless garlic extract, can lower systolic blood pressure (SBP) by approximately 3.8 mmHg. Additionally, a systematic review and meta-analysis demonstrated that aged garlic extract (AGE) can significantly improve HDL cholesterol and reduce LDL cholesterol. These effects suggest a potential role in reducing cardiovascular risk factors, especially for individuals with hypertension. The effect sizes are generally modest, and the clinical significance may vary among individuals. Benefits may be observed within several weeks to months of consistent supplementation, but long-term studies are needed to confirm sustained effects. The evidence is considered moderate, with some limitations due to variability in study quality and sample sizes.

How it works

Odorless garlic extract exerts its effects through multiple biological pathways. It inhibits angiotensin-converting enzyme (ACE), which helps to reduce blood pressure. Additionally, it reduces oxidative stress and improves endothelial function, contributing to cardiovascular health. Key molecular targets include the endothelial nitric oxide synthase (eNOS) pathway, which is involved in vasodilation, and the reduction of inflammatory markers such as C-reactive protein (CRP). The active compounds, such as S-allyl-cysteine, are well-absorbed, contributing to the extract's bioavailability. These mechanisms collectively support the observed benefits in blood pressure and lipid profiles.

Side effects

Odorless garlic extract is generally considered safe, with fewer reported side effects compared to raw garlic. Common side effects, though less frequent than with raw garlic, may include bad body and breath odor. Uncommon side effects reported in a small percentage of users include flatulence, heartburn, and mouth ulcers. Rare side effects include rash and other minor symptoms in isolated cases. Garlic supplements can interact with certain medications, particularly those with narrow therapeutic indices, affecting their absorption and metabolism. Individuals with bleeding disorders or those taking anticoagulant medications should use garlic supplements with caution due to their potential antiplatelet effects. Pregnant or breastfeeding women should consult their healthcare provider before using garlic supplements due to limited data on their safety in these populations.

Dosage

Recommended dosages of odorless garlic extract typically range from 240 mg to 960 mg per day, with higher doses showing more significant effects in some studies. The minimum effective dose is not well-established, but consistent daily dosing is recommended to maintain therapeutic levels of the active compounds. There is no established maximum safe dose, but doses above 960 mg per day are less commonly studied. Enteric-coated tablets may enhance bioavailability and reduce gastrointestinal side effects. The bioavailability of odorless garlic extract can be influenced by the formulation and the presence of other nutrients. A balanced diet may enhance the overall effectiveness of the supplement.

FAQs

How long does it take to see benefits?

Benefits may be observed within several weeks to months of consistent supplementation. Long-term studies are needed to confirm sustained effects.

Are there any interactions with medications?

Yes, garlic supplements can interact with certain medications, particularly those with narrow therapeutic indices. Consult with a healthcare provider.

Is it safe for everyone?

Generally safe, but caution is advised for individuals with bleeding disorders or those taking anticoagulant medications. Consult with a healthcare provider.

What can I expect in terms of blood pressure reduction?

A reduction of approximately 3.8 mmHg in systolic blood pressure has been observed in studies using garlic preparations.

Does odorless garlic extract have the same benefits as raw garlic?

While it has some similar benefits, the bioactive compounds and their effects may differ due to the processing methods used to reduce the odor.

Research Sources

https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/411743 – This systematic review and meta-analysis, involving 482 subjects from 9 trials, found that garlic preparations, including odorless garlic extract, reduced systolic blood pressure by approximately 3.8 mmHg. The study highlights the potential of garlic in managing hypertension but notes the need for longer-term and higher-quality trials due to heterogeneity among studies.
https://pubmed.ncbi.nlm.nih.gov/31294508/ – This systematic evaluation of clinical evidence assessed 24 clinical studies and found moderate evidence for cardiovascular risk reduction with odorless garlic. However, the review also noted significant methodological flaws in many studies, emphasizing the need for long-term confirmatory studies to validate these findings.
https://academic.oup.com/ajh/article/28/3/414/2743421?login=false – This systematic review and meta-analysis examined the effect of garlic extract on markers of lipid metabolism and cardiovascular risk. The study found significant improvements in HDL cholesterol and reductions in LDL cholesterol, particularly in coronary artery disease (CAD) patients, suggesting a beneficial impact on lipid profiles. The authors note variability in study quality and composition of garlic products as limitations.
https://www.science.gov/topicpages/e/enteric-coated+garlic+supplement – This source discusses the benefits of enteric-coated garlic supplements, highlighting that this formulation may enhance bioavailability and reduce gastrointestinal side effects. The enteric coating helps to protect the active compounds from stomach acid, allowing for better absorption in the intestines.
https://pubmed.ncbi.nlm.nih.gov/36640154/ – This study investigates the impact of aged garlic extract on cardiovascular health. The findings suggest that aged garlic extract can improve HDL cholesterol levels and reduce LDL cholesterol levels, indicating a positive effect on lipid metabolism and cardiovascular risk. The research contributes to the growing body of evidence supporting the potential benefits of aged garlic extract in managing cardiovascular health.