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Oldenlandia

Also known as: Oldenlandia diffusa, Oldenlandia hedyotidea, Snake jasmine, Bái huā shé shé cǎo, Sweet tea

Overview

Oldenlandia encompasses several plant species, notably *Oldenlandia diffusa* and *Oldenlandia hedyotidea*, traditionally used in Asian medicine. *Oldenlandia diffusa*, also known as snake jasmine or bái huā shé shé cǎo, and *Oldenlandia hedyotidea*, or sweet tea, are valued for their potential therapeutic effects. These plants contain bioactive compounds like iridoids and anthraquinones, believed to contribute to their medicinal properties. Traditionally, they have been used to treat conditions such as cancer, arthritis, and autoimmune diseases. However, current research is primarily based on in vitro and animal studies, with limited human clinical trials. The available evidence is largely observational or experimental, lacking rigorous, large-scale randomized controlled trials (RCTs).

Benefits

Research suggests that *Oldenlandia diffusa* may have antiproliferative and apoptotic effects, particularly in hepatocellular carcinoma models, as evidenced by studies showing tumor size reduction in rats [1]. Potential benefits for autoimmune diseases and inflammation have also been anecdotally reported, but lack robust evidence. The effect sizes are generally not well-quantified due to the scarcity of large-scale human trials. While in vitro studies on *Oldenlandia hedyotidea* have identified bioactive compounds with anticancer effects [3], these findings require validation through clinical trials to confirm their efficacy and safety in humans. The time course of benefits is not well-established.

How it works

The bioactive compounds in *Oldenlandia* species are believed to interact with cellular pathways involved in cell proliferation and apoptosis. These compounds may affect immune and cellular systems, although the specific mechanisms are not fully understood. Research indicates potential interactions with molecular targets, but these are not well-defined in human studies. Limited data is available regarding the absorption and bioavailability of these compounds, particularly in humans, which further complicates understanding of their mechanism of action.

Side effects

The safety profile of Oldenlandia is not well-established due to limited human studies. While generally considered safe in traditional use, formal safety assessments are lacking. Common, uncommon, and rare side effects are not well-documented. Potential interactions with other medications have not been thoroughly studied. Contraindications are not established, but caution is advised for pregnant or breastfeeding women due to the lack of safety data. Further research is needed to comprehensively assess the safety and potential adverse effects of Oldenlandia.

Dosage

There are no established minimum effective, optimal, or maximum safe doses for Oldenlandia. Traditional use typically involves decoctions, but specific dosages are not standardized. Timing considerations, form-specific recommendations, absorption factors, and required cofactors are unknown. Due to the lack of standardized dosing and safety data, users should consult with healthcare providers before using Oldenlandia. More research is needed to determine appropriate dosing guidelines and safety thresholds.

FAQs

Is Oldenlandia safe to use?

While traditionally used, formal safety assessments are needed. Limited human studies mean potential side effects and drug interactions are not well-understood. Consult a healthcare provider before use.

How should I take Oldenlandia?

No specific timing or administration guidelines are established. Traditional preparations involve decoctions, but standardized dosages are lacking. Consult a healthcare provider for personalized advice.

What results can I expect from taking Oldenlandia?

Benefits are largely theoretical, based on in vitro and animal studies. Human clinical trials are needed to confirm efficacy. Do not rely solely on Oldenlandia for treating any medical condition.

Are there any misconceptions about Oldenlandia?

A common misconception is assuming efficacy based on traditional use without robust clinical evidence. More rigorous research is needed to establish its benefits and safety in humans.

Research Sources

https://onlinelibrary.wiley.com/doi/10.1155/2015/501508 – This study investigated the effects of *Oldenlandia diffusa* on hepatocellular carcinoma in a rat model. The results showed antiproliferative and apoptotic effects, with significant reductions in tumor size and serum markers. However, the study is limited by its use of an animal model and lack of human data.
https://onlinelibrary.wiley.com/doi/10.1002/ptr.8288 – This analysis identified several bioactive compounds in *Oldenlandia hedyotidea*, including iridoids and anthraquinones. The study demonstrated anticancer effects in vitro, highlighting the potential for further research into the medicinal properties of these compounds. It suggests potential benefits but requires validation through clinical trials.
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.624296/full – This study likely explores the pharmacological properties of Oldenlandia, potentially focusing on its effects on various biological pathways. Further examination of the full text is needed to provide a more detailed summary of its findings and implications for human health.
https://www.mdpi.com/1424-8247/15/11/1371 – This study likely investigates the chemical composition and potential therapeutic applications of Oldenlandia. A detailed analysis of the full text is necessary to understand the specific compounds identified and their potential benefits, as well as any limitations of the research.
https://eprints.kingston.ac.uk/id/eprint/20412/1/Ganbold-M.pdf – This study assessed the cytotoxicity of *Oldenlandia diffusa* on cancer cell lines. The results showed growth inhibition effects, indicating potential anticancer activity. However, the study is limited by its focus on in vitro experiments without human clinical trials.