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Olive

Also known as: Olive leaf extract, OLE, Olive leaf, Olea europaea

Overview

Olive leaf extract (OLE) is derived from the leaves of the olive tree, *Olea europaea*. It is a herbal supplement rich in bioactive compounds, most notably oleuropein, a potent antioxidant and anti-inflammatory agent. OLE is primarily used for its potential cardiovascular benefits, including lowering blood pressure and improving lipid profiles. Research suggests that OLE's high concentration of polyphenols contributes to its health-promoting effects. It is available in various forms, including capsules, tablets, and liquid extracts. While generally considered safe, it's essential to be aware of potential side effects and interactions, especially for individuals with pre-existing conditions or those taking medications for blood pressure or diabetes. The quality of evidence supporting its cardiovascular benefits is generally good, with several systematic reviews and meta-analyses available.

Benefits

Olive leaf extract has shown promise in several key areas, particularly for cardiovascular health. Studies indicate a significant reduction in systolic blood pressure (SBP), with an average decrease of approximately 7.05 mmHg. Additionally, OLE supplementation has been linked to improved lipid profiles, including reductions in total cholesterol (TC) and triglycerides (TG), with mean decreases of about 6.69 mg/dl for TC and 9.21 mg/dl for TG. These benefits are particularly pronounced in individuals with hypertension. While some studies suggest potential benefits for metabolic parameters like glucose control, the evidence is less consistent. The observed effect sizes for blood pressure and lipid profiles are clinically significant, making OLE a potentially valuable supplement for managing cardiovascular risk factors.

How it works

Olive leaf extract exerts its effects primarily through its antioxidant and anti-inflammatory properties. Oleuropein, a major bioactive compound in OLE, plays a key role in these pathways. The extract primarily affects the cardiovascular and metabolic systems. Oleuropein may interact with various molecular targets involved in blood pressure regulation and lipid metabolism. While the exact mechanisms are still being investigated, it is believed that OLE helps to reduce oxidative stress and inflammation, which are key contributors to cardiovascular disease. The bioavailability of oleuropein and other polyphenols can vary, but they are generally well-absorbed when ingested.

Side effects

Olive leaf extract is generally considered safe for short-term use, but some side effects have been reported. The most common side effect is gastrointestinal upset, which may occur in some individuals. Less common side effects include potential allergic reactions or interactions with certain medications, although these are not well-documented. Due to its effects on blood pressure and glucose metabolism, OLE may interact with blood thinners or diabetes medications. It is contraindicated during pregnancy and breastfeeding due to limited safety data. Caution is advised in individuals with severe hypertension or those taking medications for blood pressure or diabetes. It is important to monitor blood pressure and glucose levels when taking OLE, especially if you have pre-existing conditions or are taking medications that affect these parameters.

Dosage

The typical effective dose of olive leaf extract is around 500 mg per day. Optimal dosage ranges from 500-1000 mg per day, depending on the specific formulation and individual response. Doses above 1000 mg per day are less commonly studied, and the maximum safe dose is not well-established. It is best taken with meals to minimize gastrointestinal side effects. Capsules or tablets are common forms. Bioavailability may be enhanced with food intake. There are no specifically identified required cofactors. Individuals should consult with a healthcare provider to determine the appropriate dosage based on their individual needs and health status.

FAQs

Is olive leaf extract safe?

Generally safe, but monitor blood pressure and glucose levels if taking medications. Consult a healthcare provider before use, especially if you have pre-existing conditions.

When is the best time to take olive leaf extract?

Take with meals to reduce the risk of gastrointestinal side effects. Consistent timing each day can also help maintain stable blood levels.

How long does it take to see results?

Noticeable improvements in blood pressure and lipid profiles may be observed within weeks to months of consistent supplementation.

Can olive leaf extract replace my blood pressure medication?

No, it is not a substitute for medical treatment. Consult a healthcare provider before use, especially if you are currently taking medication.

Are there any specific precautions I should take?

If you are pregnant, breastfeeding, or have severe hypertension, consult your doctor before using olive leaf extract.

Research Sources

https://pubmed.ncbi.nlm.nih.gov/38287654/ – This systematic review examined the impact of olive leaf extract on cardiometabolic risk factors, noting mixed results for fasting glycemia. The review suggests that while OLE may offer some benefits, the evidence for metabolic parameters is variable.
https://pubmed.ncbi.nlm.nih.gov/36271405/ – A systematic review and meta-analysis found that olive leaf extract supplementation significantly reduced blood pressure and improved lipid profiles in adults, particularly those with hypertension. The study highlights the potential of OLE as a supportive therapy for cardiovascular health.
https://academic.oup.com/nutritionreviews/article/82/12/1710/7591544 – This review provides a comprehensive overview of the health benefits of olive leaf extract, focusing on its antioxidant and anti-inflammatory properties. It discusses the potential mechanisms of action and the evidence supporting its use for various health conditions.
https://pubs.rsc.org/en/content/articlelanding/2023/fo/d3fo00488k – This study investigates the potential of olive leaf extract as a functional food ingredient. It explores the extraction methods, bioactive compounds, and potential health benefits associated with OLE consumption.
https://peerj.com/articles/11173/ – This systematic review and meta-analysis highlighted the effectiveness of olive leaf extract in improving cardiometabolic profiles, particularly lipid profiles. The study suggests that OLE may be a valuable tool for managing cardiovascular risk factors.