Ophiopogon Japonicus Tuber Extract
Also known as: Maidong, Ophiopogon japonicus, Ophiopogon tuber extract, Ophiopogonis Radix, Ophiopogon japonicus tuber extract
Overview
Ophiopogon japonicus, widely known as Maidong, is a perennial herbaceous plant primarily used in traditional Chinese medicine. The tuber of this plant is renowned for its medicinal properties, particularly within the framework of herbal remedies. The extract has been studied for its rich bioactive components, including steroidal saponins, homoisoflavonoids, and polysaccharides, contributing to its array of health benefits. Ophiopogon japonicus tuber extract is primarily noted for its anticancer, cardiovascular protective, anti-inflammatory, antimicrobial, and immunomodulating properties. Several studies have demonstrated its potential effectiveness in inducing apoptosis in cancer cells, providing heart protection, and modulating immune functions. Despite its established uses, more rigorous clinical trials are needed to further substantiation of its efficacy in humans.
Benefits
The most notable benefits of Ophiopogon japonicus tuber extract include its anticancer effects, where it can induce cell cycle arrest and apoptosis, thereby inhibiting the growth and metastasis of tumors. For instance, research shows that the extract plays a vital role in inhibiting gastric cancer cell migration. Additionally, its cardiovascular protective properties are critical for heart health, with mechanisms involving anti-inflammation and anti-oxidation. Other highlighted benefits include cough relief and potential anti-diabetic properties. These effects are supported by a growing body of evidence, although the quality of research varies, demanding further studies to confirm findings on dosage and long-term effects.
How it works
The therapeutic effects of Ophiopogon japonicus tuber extract are primarily attributed to its bioactive compounds. It is believed that these compounds interact with signaling pathways involved in cell proliferation and apoptosis. For instance, ruscogenin and ophiopogonin silicate engage in mechanisms that disrupt cancer cell cycles, induce programmed cell death, and hinder processes such as angiogenesis and metastasis. Additionally, its polysaccharides contribute to immune modulation and exhibit antioxidative properties, enhancing cardiovascular health.
Side effects
Ophiopogon japonicus tuber extract is generally considered safe for consumption in moderate amounts. However, potential side effects may include gastrointestinal discomfort and allergic reactions in sensitive individuals. The frequency and severity of these adverse effects have not been extensively documented, prompting caution among users with known allergies to similar herbal products. Moreover, interactions with medications, particularly those that modulate heart function or immune response, warrant careful attention. Individuals with specific conditions such as hypotension or those undergoing allergy treatments should consult healthcare professionals before using this extract.
Dosage
The recommended dosage of Ophiopogon japonicus tuber extract typically ranges from 500 mg to 2,000 mg per day, divided into multiple servings. Timing may vary based on use; for instance, individuals taking the supplement for cancer-related benefits may be advised to take it consistently throughout the day, while for cardiovascular support, it could align with meal times. Absorption rates may differ based on the form of extract, with liquid forms often being better absorbed than powders. Upper limits have not been firmly established due to insufficient human studies, yet users are encouraged to follow product guidelines and consult healthcare providers, especially if they are pregnant, nursing, or on medications.
FAQs
What are the primary uses of Ophiopogon japonicus tuber extract?
Ophiopogon japonicus tuber extract is primarily used for its anticancer properties, cardiovascular health benefits, and immune modulation.
Are there any side effects associated with this extract?
While generally safe, potential side effects include gastrointestinal discomfort and allergic reactions in sensitive individuals.
How should I take Ophiopogon japonicus tuber extract?
The typical dosage ranges from 500 mg to 2,000 mg per day, divided into multiple servings. Consistency is important for maximum effectiveness.
Can Ophiopogon japonicus interact with medications?
Yes, it may interact with medications that affect heart function or immune system responses, so consulting a healthcare provider is recommended.
Is Ophiopogon japonicus tuber extract safe during pregnancy?
Safety during pregnancy is not well-established, so pregnant or nursing individuals should consult their healthcare provider before use.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/36854203/ – This systematic review discusses the anticancer potential of Ophiopogon japonicus extracts, finding strong evidence for inducing apoptosis and inhibiting tumor progression, suggesting its potential as a safe anticancer drug candidate.
- https://pubmed.ncbi.nlm.nih.gov/26826325/ – This ethnopharmacological review provides insights into the pharmacological properties and traditional uses of Ophiopogon japonicus, highlighting its potential therapeutic benefits across various health conditions.
- https://www.mdpi.com/1422-0067/22/5/2735 – The study explores the inhibitory effects of exopolysaccharides derived from Ophiopogon japonicus endophytes on gastric cancer cells, indicating potential as natural antitumor agents.
- https://tcr.amegroups.org/article/view/25951/html – This article reviews the various pharmacological activities of Ophiopogon japonicus, presenting evidence for its use in cancer therapies and highlighting the need for further clinical evidence.
- https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2023.1183096/full – This article discusses the effects of Ophiopogon japonicus tuber extract in nutrition and wellness, framing its benefits within a historical and modern clinical context, and calls for more comprehensive studies.
