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Ophiopogon Tuber Extract

Also known as: Dwarf Lilyturf, Mondo Grass, Ophiopogon Tuber, *Ophiopogon japonicus*

Overview

*Ophiopogon japonicus* is a perennial herbaceous plant native to East Asia, primarily recognized for its tuberous roots. This plant has a long history of use in traditional Chinese medicine, where it is believed to offer various health benefits. Extracts from its tubers are noted for their potential anti-inflammatory, immunomodulatory, and anticancer effects. Constituents such as ruscogenin and ophiopogonins are crucial to these properties, though comprehensive research, particularly high-quality clinical studies, remains limited. Current investigations are focused on understanding its efficacy in cancer treatment and its broader pharmacological implications.

Benefits

Research suggests that *Ophiopogon japonicus* may exert anticancer effects through several mechanisms, including inducing apoptosis (programmed cell death) and inhibiting cancer cell metastasis and angiogenesis (the formation of new blood vessels). Additionally, it shows promise for its anti-inflammatory and antioxidant properties, though quantitative data on human populations is scarce. Hence, while the findings are encouraging, particularly from in vitro and in vivo studies, the clinical significance and specific populations that may benefit remain unclear.

How it works

The potential mechanisms of *Ophiopogon japonicus* include the induction of apoptosis in cancer cells, facilitation of autophagy, and cell cycle arrest. These interactions suggest a multidimensional approach to cancer treatment, where compounds in the extract potentially modulate immune responses and reduce inflammation, engaging with both the immune and cardiovascular systems.

Side effects

Currently, the safety profile of *Ophiopogon japonicus* suggests that it is generally considered safe; however, evidence from high-quality human studies is lacking. There are no well-documented common or rare side effects, and potential drug interactions have not been extensively evaluated. As with any herbal supplement, caution is advised particularly for pregnant or breastfeeding women, due to insufficient data on safety in these populations. It is also recommended to consult healthcare providers before beginning supplementation, especially if other medications are involved.

Dosage

There is currently no established minimum effective dose or optimal dosage range for *Ophiopogon japonicus*. Both the maximum safe dose and specific timing considerations remain undefined. The absorption factors and requirements for co-factors are not well-studied; therefore, users are encouraged to follow healthcare provider recommendations. Due to the lack of precise dosing guidelines, it is critical to approach usage cautiously and within a supervised framework.

FAQs

Is *Ophiopogon japonicus* safe to take?

While generally considered safe, there is minimal human safety data available. Consulting with a healthcare provider before use is advisable.

What benefits can I expect from *Ophiopogon japonicus*?

Potential benefits include anti-inflammatory and anticancer effects, but robust human data is limited; outcomes may vary.

Can *Ophiopogon japonicus* interact with other medications?

Potential drug interactions are not well-studied. It's essential to discuss all supplements with a healthcare provider, especially if taking other medications.

How should *Ophiopogon japonicus* be taken?

Dosage and timing guidelines have not been established; it’s important to follow healthcare provider recommendations concerning use.

Is *Ophiopogon japonicus* a substitute for prescription medications?

It is not a substitute for medical treatment; advice from a healthcare provider is necessary for anyone considering it for health conditions.

Research Sources

https://pubmed.ncbi.nlm.nih.gov/36854203/ – This study reviews the potential anticancer effects of *Ophiopogon japonicus* extracts, primarily highlighting its mechanisms of action such as apoptosis induction. It underscores the need for more robust human trials.
https://www.mdpi.com/1422-0067/22/5/2735 – This review discusses the phytochemical properties and pharmacological potential of *Ophiopogon japonicus*, focusing on its various health benefits and necessitating further investigations to validate findings from preliminary studies.
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.769929/full – The article provides comprehensive insights into the pharmacological properties of *Ophiopogon japonicus*, including its anti-inflammatory and antioxidant activities. It highlights gaps in knowledge regarding high-quality clinical research.