Ophiopogonis Extract
Also known as: Ophiopogonis Root, Maidong, Dwarf Lilyturf Root, *Ophiopogon japonicus*
Overview
*Ophiopogon japonicus* is a perennial plant in the Liliaceae family, primarily found in East Asia. Its tuberous roots are widely utilized in traditional Chinese medicine (TCM) for a variety of health benefits. The extract is rich in bioactive compounds including polysaccharides, saponins, homoisoflavonoids, amino acids, and nucleosides. It has traditionally been employed for enhancing respiratory and cardiovascular health and serves as an adjunct in various health applications. Despite its extensive use in TCM, scientific investigations are still developing, largely consisting of in vitro, animal studies, and a few human studies with moderate evidence supporting its claimed effects. Important constituents include essential nutrients such as potassium and vitamin B2, though the overall research quality remains limited.
Benefits
Evidence supporting the health benefits of *Ophiopogon japonicus* is mainly anecdotal, rooted in traditional uses rather than robust scientific trials. While studies suggest potential anti-inflammatory, antioxidant, and immunomodulatory effects, the quality of this evidence is inconsistent. Some clinical findings indicate possible improvements in respiratory function and cardiovascular protection, yet systematic reviews and meta-analyses to validate these claims are lacking. Consequently, there is no defined population that benefits distinctly from *Ophiopogon japonicus*, nor precise quantifications of effect sizes and clinical significance.
How it works
The bioactive compounds derived from *Ophiopogon japonicus* are hypothesized to engage with various biological pathways relevant to metabolism and immune response. They may influence galactose metabolism, starch and sucrose metabolism, as well as glycerophospholipid metabolism. However, the specific mechanisms by which these compounds exert their effects remain partially characterized and the exact molecular targets are yet to be elucidated through comprehensive studies.
Side effects
*Ophiopogon japonicus* is generally regarded as safe when consumed at traditional dosages; however, comprehensive safety data is lacking. Notably, the absence of documented common, uncommon, or rare side effects limits understanding of its safety profile. Potential drug interactions are poorly studied, and while no known contraindications exist, caution is advised particularly due to the insufficient evidence regarding its effects on special populations, such as pregnant women and children. Further research is necessary to delineate any adverse effects that may occur.
Dosage
Due to the absence of established clinical trials, no minimum effective dose or maximum safe dosage for *Ophiopogon japonicus* is clearly defined. Traditional usage suggests varying dosages, yet optimal ranges require scientific validation. While timing for administration has not been specified, fresh processing recommendations include slicing the root and drying it under specific conditions to maintain its qualities. Information on absorption factors and required cofactors for efficacy remains sparse and unexamined in the current literature.
FAQs
Is *Ophiopogon japonicus* safe to use?
It is generally considered safe when used acutely or according to traditional guidelines, but comprehensive safety data is limited.
What benefits can I expect from *Ophiopogon japonicus*?
Potential benefits include improved respiratory and cardiovascular health, but clinical evidence is weak; results may vary.
How should I take *Ophiopogon japonicus*?
There are no specific guidelines for timing and administration, so traditional practices vary widely.
Are there any known side effects?
Common side effects have not been well-documented, thus potential adverse effects remain largely unknown.
What is the main use of *Ophiopogon japonicus*?
It is primarily used for its traditional health benefits, notably in TCM for respiratory and cardiovascular health.
Research Sources
- https://www.degruyter.com/document/doi/10.1515/biol-2022-0096/html?lang=en – This study utilized advanced analytical techniques to evaluate the bioactive compounds in *Ophiopogon japonicus*, identifying key metabolites like saponins and flavonoids, and highlighted regional variability in extract quality.
- https://pubmed.ncbi.nlm.nih.gov/31602876/ – The nutritional composition of *Ophiopogon japonicus* was analyzed, with findings indicating that it is low in fats but rich in polysaccharides, potassium, and vitamin B2, suggesting its role as a therapeutic food.
- https://www.degruyter.com/document/doi/10.1515/biol-2022-0638/html – This research provided insights into fresh processing techniques for *Ophiopogon japonicus*, recommending specific drying methods to retain quality, which could influence its therapeutic efficacy.