Organic Andrographis Aerial Parts Extract
Also known as: Kalmegh, Green Chiretta, King of Bitters, *Andrographis paniculata*
Overview
*Andrographis paniculata*, commonly known as Kalmegh or King of Bitters, is a medicinal herb native to South Asia. The therapeutic potential of its aerial parts, particularly the extract rich in andrographolide, has gained prominence in traditional Ayurvedic and Chinese medicine. Utilized primarily for its antiviral, anti-inflammatory, and immunomodulatory properties, it is frequently employed to alleviate respiratory symptoms and inflammatory conditions. The extract contains various bioactive compounds such as diterpenoids and flavonoids, contributing to its efficacy. Evidence supports its traditional uses, showing a robust scientific investigation into its pharmacological benefits, particularly against respiratory infections. Research indicates significant efficacy, particularly in reducing the duration of symptoms related to viral infections like influenza and SARS-CoV-2.
Benefits
*Andrographis paniculata* has several evidence-based benefits. Clinical studies have demonstrated its significant antiviral effect, notably reducing cold symptom duration by about 1.5 days compared to placebo (p < 0.05). Anti-inflammatory properties help manage conditions like arthritis, providing moderate to large effects on inflammatory markers. Populations at higher risk for respiratory infections, such as the elderly and those with weak immune systems, may note the greatest benefit. Symptoms typically improve within 3-7 days of beginning treatment, illustrating its effectiveness for acute respiratory conditions.
How it works
Andrographolide from *Andrographis paniculata* exerts its effects through several biological mechanisms, primarily by inhibiting pro-inflammatory cytokines and modulating immune responses. It targets key pathways, including the NF-kB signaling pathway, crucial for inflammatory responses. Consequently, this interaction enhances the immune system's ability to combat infections while promoting anti-inflammatory effects.
Side effects
Generally considered safe for most individuals, *Andrographis paniculata* may cause some gastrointestinal disturbances, with side effects such as nausea, diarrhea, and skin rashes occurring in over 5% of users. Less common effects (<5%) may include mild liver enzyme elevations and allergic reactions. Rarely (<1%), severe allergic reactions such as anaphylaxis can occur. Caution is advised when used with anticoagulants and antihypertensive drugs. Those with known allergies to this plant should avoid it, and pregnant or breastfeeding women should use it cautiously due to limited safety data.
Dosage
The minimum effective dose of *Andrographis paniculata* is around 300 mg of standardized extract per day, with usual recommendations ranging from 600 to 1200 mg daily, ideally divided into two or three doses. Maximum safe doses up to 1800 mg per day have been clinically tested without significant adverse effects. For optimal absorption, it is best taken with meals. Extracts should be standardized to contain at least 10% andrographolide, and formulations that enhance bioavailability are recommended.
FAQs
Is *Andrographis paniculata* safe for long-term use?
While generally safe for short-term use, long-term safety data are limited, and caution is advised.
When should I take *Andrographis paniculata*?
It should be taken consistently, ideally at the same time each day, to optimize results.
How quickly can I expect results?
Symptom relief from respiratory infections is typically noted within a week of starting supplementation.
Is it only effective for acute infections?
Contrary to popular belief, it also has benefits in managing chronic inflammatory conditions.
Research Sources
- https://pmc.ncbi.nlm.nih.gov/articles/PMC9316804/ – This systematic review analyzed ten randomized controlled trials (RCTs) and found a very low incidence of serious adverse events related to *Andrographis paniculata*, primarily gastrointestinal issues.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC11813351/ – A review confirmed the broad-spectrum antimicrobial activity of andrographolide, supporting its traditional use in various infections.
- https://www.sysrevpharm.org/articles/a-prospective-review-on-phytopharmacological-aspects-of-andrographis-paniculata.pdf – This comprehensive review highlighted the pharmacological properties of *A. paniculata*, emphasizing its antiviral, anti-inflammatory, and immunomodulatory effects, particularly in managing COVID-19 symptoms.
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