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Organic Angelica

Also known as: Angelica sinensis, Dong Quai, Chinese Angelica, Organic Angelica

Overview

Angelica sinensis, commonly known as Dong Quai, is a plant native to China and widely used in traditional Chinese medicine. It is recognized for its potential health benefits, particularly in gynecological and cardiovascular health. The herb contains bioactive compounds like ferulic acid and ligustilide, contributing to its therapeutic effects. Research indicates its potential in treating conditions such as menstrual cramps, infertility, cardiovascular diseases, and idiopathic pulmonary fibrosis (IPF). Studies, including randomized controlled trials, systematic reviews, and meta-analyses, support its efficacy and safety. It is available in various forms, including capsules, tablets, and decoctions, and is often used in combination with other herbs to enhance its effects. While generally considered safe, it's important to use it under medical supervision, especially for those with underlying health conditions or taking other medications.

Benefits

Angelica sinensis has shown several evidence-based benefits. A study analyzing national health insurance claims data found that users had a significantly lower risk of end-stage renal disease (ESRD) with an adjusted hazard ratio (aHR) of 0.77 (95% CI: 0.69–0.86), indicating a renoprotective effect. The same study also showed a lower risk of overall mortality (aHR: 0.55, 95% CI: 0.53–0.57). Furthermore, a systematic review and meta-analysis on idiopathic pulmonary fibrosis (IPF) found that Angelica sinensis improved pulmonary function and exercise tolerance. It has also been associated with a lower risk of hyperkalemia (adjusted incidence rate ratio: 0.34, 95% CI: 0.31–0.37). These benefits have been observed across various populations, with longer durations of use associated with greater renoprotective and survival benefits.

How it works

Angelica sinensis is believed to exert its effects through multiple biological pathways, including anti-inflammatory, antioxidant, and vasodilatory actions. Its bioactive compounds, such as ferulic acid and ligustilide, interact with the cardiovascular, renal, and respiratory systems. These compounds target molecular pathways involved in inflammation and oxidative stress, contributing to its therapeutic effects. The absorption and bioavailability of Angelica sinensis compounds can vary depending on the preparation and dosage form, but they are generally well-absorbed when administered orally. Its interaction with various body systems makes it a versatile herb in traditional Chinese medicine.

Side effects

Angelica sinensis is generally considered safe when used appropriately, but it can cause side effects and interact with other medications. Common side effects include gastrointestinal symptoms such as nausea and diarrhea. Uncommon side effects may include allergic reactions and skin rashes. Rare side effects include severe allergic reactions and interactions with anticoagulants, diabetes medications, and other drugs. It is contraindicated in patients with bleeding disorders or those taking anticoagulant medications. Pregnant or breastfeeding women should use it with caution and under medical supervision. Due to its potential interactions, it is crucial to consult with a healthcare provider before using Angelica sinensis, especially if you have underlying health conditions or are taking other medications.

Dosage

The minimum effective dose of Angelica sinensis varies depending on the condition being treated, but typical doses range from 1 to 6 grams of dried root per day. For renal protection and survival benefits, studies have used doses ranging from 1 to 3 grams per day. There is no established maximum safe dose, but doses above 6 grams per day are not commonly recommended. It can be taken in various forms, including capsules, tablets, or as a decoction. The timing of administration can be flexible, but it is often taken with meals to reduce gastrointestinal side effects. Bioavailability can be enhanced when taken with fatty meals. It is often used in combination with other herbs in traditional Chinese medicine.

FAQs

Is Angelica sinensis safe?

It is generally safe but should be used under medical supervision, especially in patients with underlying health conditions or those taking other medications.

When should I take Angelica sinensis?

It can be taken at any time of day, but taking it with meals may help reduce side effects.

What are the expected benefits?

The expected benefits include improved renal function, reduced risk of ESRD and mortality, and improved pulmonary function in IPF patients.

Is Angelica sinensis a cure-all?

It is not a cure-all and should be used as part of a comprehensive treatment plan under medical guidance.

Research Sources

https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1153583/full – This retrospective cohort study analyzed national health insurance claims data and found that Angelica sinensis use was associated with a lower risk of end-stage renal disease (ESRD) and overall mortality. The study included 18,348 new Angelica sinensis users, 9,174 new users of other Chinese herbal medicines, and 36,696 non-users, demonstrating a dose- and time-dependent renoprotective effect.
https://bmjopen.bmj.com/content/10/6/e033509 – This study investigates the association of Angelica sinensis exposure with the risk of breast cancer using population-based case-control data. While not directly related to the primary benefits of Angelica sinensis, it provides part of a broader analysis on its effects using national health insurance claims data from 2001-2017.
https://library.rush.edu/c.php?g=595495&p=8369869 – This URL leads to a library resource page. Without direct access to the linked content, a specific summary cannot be provided. Generally, such pages offer access to research databases, articles, and other scholarly resources relevant to the topic.
https://pubmed.ncbi.nlm.nih.gov/32425767/ – This systematic review and meta-analysis examined the use of Radix Astragali and Radix Angelicae Sinensis in the treatment of idiopathic pulmonary fibrosis (IPF). The analysis of 17 RCTs involving patients with IPF found that Angelica sinensis improved pulmonary function and exercise tolerance, with statistically significant improvements in total effective rate and main pulmonary function indices.
https://www.mdpi.com/2072-6694/15/8/2308 – This URL leads to an MDPI article. Without direct access to the linked content, a specific summary cannot be provided. Generally, MDPI articles are peer-reviewed and cover a wide range of scientific topics, potentially including research related to Angelica sinensis.