Organic Cynara Scolymus
Also known as: Artichoke, Globe Artichoke, Cynara scolymus
Overview
Cynara scolymus, commonly known as the artichoke, is a thistle-like plant native to the Mediterranean region. It is widely consumed as a food and is also used as a dietary supplement due to potential health benefits. Artichoke is rich in bioactive compounds including flavonoids and phenolic acids, which contribute to its antioxidant, lipid-lowering, and hepatoprotective properties. Artichoke supplements have gained attention in health research, supported by a robust body of clinical trials and systematic reviews. As a component of the Mediterranean diet, artichoke is considered beneficial for liver health and cardiovascular function, with high-quality research indicating its effectiveness in improving various health parameters.
Benefits
Artichoke supplementation provides several evidence-based health benefits: It exhibits significant antioxidant activity, enhancing levels of antioxidant enzymes while reducing oxidative stress markers in animal studies. Meta-analyses of clinical trials demonstrate that artichoke extract can significantly lower total cholesterol, LDL cholesterol, and triglycerides, particularly benefiting individuals with hyperlipidemia. Additionally, artichoke supplementation effectively reduces liver enzymes such as AST and ALT, proving especially advantageous for patients with non-alcoholic fatty liver disease (NAFLD). The body of evidence suggests moderate to large effect sizes for these outcomes, with continual supplementation showing sustained benefits over several weeks to months.
How it works
Artichoke extracts exert their effects through multiple biological pathways. The bioactive compounds enhance antioxidant defenses and inhibit lipid peroxidation, thereby improving lipid profiles and supporting liver function. These compounds interact with metabolic pathways, modulating liver enzyme activity and promoting cardiovascular health. Studies indicate good absorption and bioavailability of artichoke's active components, which reinforces its efficacy in the body.
Side effects
Artichoke supplements are considered generally safe, with common side effects including gastrointestinal symptoms like bloating and gas, occurring in over 5% of users. Uncommon side effects (1-5%) may include mild allergic reactions or digestive issues. Serious side effects are rare. Potential drug interactions may occur with lipid-lowering medications, although this is not extensively studied. Contraindications include known allergies to artichokes and bile duct obstruction, as well as consideration for pregnant or breastfeeding women who should consult healthcare providers before use due to limited safety data in these populations.
Dosage
Standard dosage recommendations for artichoke extract range from 500 mg to 1,500 mg per day. For optimal benefits in lipid reduction and liver health, an intake of 1,000 mg to 1,500 mg daily is advised. While there is no established maximum safe dose, use beyond 1,500 mg per day is less commonly researched. It is recommended to take artichoke supplements with meals to enhance absorption, particularly with healthy fats. Standardized extracts containing key bioactive components like cynarin are preferred to maximize benefits.
FAQs
Are artichoke supplements safe to use?
Generally, yes. Artichoke supplements are safe for most users, but those with allergies or specific health conditions should consult their healthcare provider.
When should I take artichoke supplements?
It is advisable to take artichoke supplements with meals to improve absorption and overall efficacy.
What results can I expect from artichoke supplementation?
Users can expect improvements in cholesterol levels and liver enzyme function typically within several weeks to a few months of consistent use.
Can I rely on artichoke supplements instead of medication?
Artichoke supplements should not replace prescribed medications but may serve as complementary therapy under healthcare guidance.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/30345589/ – This systematic review and meta-analysis focusing on antioxidant activity indicated that artichoke extract significantly enhanced antioxidant enzyme levels and reduced oxidative stress markers in animal studies, highlighting its potential as a dietary supplement.
- https://pubmed.ncbi.nlm.nih.gov/34383355/ – This study reviewed multiple clinical trials and determined that artichoke supplementation notably reduced liver enzymes AST and ALT, particularly beneficial for patients with NAFLD, providing strong evidence of its hepatoprotective effects.
- https://pubmed.ncbi.nlm.nih.gov/28609140/ – The systematic review and meta-analysis summarized in this article found that artichoke extract supplementation significantly lowered total cholesterol, LDL cholesterol, and triglycerides across multiple trials, affirming its lipid-lowering capabilities.
