Organic Grape Resveratrol extract
Also known as: Resveratrol, trans-resveratrol, grape resveratrol extract, 3,5,4'-trihydroxy-trans-stilbene, Organic grape resveratrol extract
Overview
Resveratrol is a naturally occurring polyphenol found in the skin of grapes, especially red grapes, and in grape-derived products like wine and grape extracts. Organic grape resveratrol extract is isolated from organically grown grapes. It's used as a dietary supplement for its antioxidant, anti-inflammatory, cardioprotective, neuroprotective, and potential anti-aging effects. Resveratrol possesses potent antioxidant properties, modulates inflammatory pathways, and influences gene expression related to oxidative stress and inflammation. Research includes numerous clinical trials and systematic reviews, although some effects remain uncertain. Evidence quality varies, including randomized controlled trials (RCTs), systematic reviews, and meta-analyses with different sample sizes and methodologies. It is available in various forms, including capsules, tablets, and powders, often standardized to a specific resveratrol content.
Benefits
Resveratrol exhibits significant antioxidant activity, increasing antioxidant agents in the body and reducing oxidative stress markers. A one-year RCT in hypertensive type 2 diabetic patients demonstrated downregulation of pro-inflammatory cytokines and modulation of inflammation-related microRNAs in immune cells with 8 mg daily grape extract containing resveratrol. It may also offer cardioprotective effects through improved endothelial function and reduced oxidative damage. In vitro and animal studies suggest neuroprotective and anti-cancer properties, with limited but promising clinical data. Patients with type 2 diabetes and hypertension may experience immunomodulatory and anti-inflammatory benefits. Long-term supplementation (≥1 year) appears necessary to observe significant molecular and immunological changes.
How it works
Resveratrol neutralizes reactive oxygen species (ROS) directly as an antioxidant. It modulates signaling pathways related to inflammation, including NF-κB and cytokine expression. It acts on immune cells to reduce pro-inflammatory gene expression and influences cardiovascular and nervous systems through antioxidant and gene regulatory effects. Known molecular targets include SIRT1 activation, linked to longevity and metabolic regulation, and inhibition of pro-inflammatory transcription factors. Oral bioavailability is relatively low due to rapid metabolism; however, metabolites may also contribute to biological effects.
Side effects
Resveratrol is generally regarded as safe with a low incidence of adverse effects at typical supplemental doses. Common side effects include mild gastrointestinal discomfort. Uncommon side effects may include headache and dizziness. Allergic reactions are rare. Potential interactions with anticoagulants and antiplatelet drugs exist due to mild blood-thinning effects. Caution is advised in individuals on blood thinners or with bleeding disorders. Limited data exists for pregnant or breastfeeding women, so caution is recommended. High doses may increase the risk of side effects.
Dosage
Clinical studies show effects at doses as low as 8 mg/day in grape extract form. Typical supplementation ranges from 100 mg to 500 mg pure resveratrol daily in clinical trials; grape extract doses vary based on resveratrol content. Up to 1 gram per day is generally considered safe in short-term studies; long-term safety at high doses is less established. Consistent daily dosing is recommended, and absorption may be improved with meals. Organic grape resveratrol extract standardized for resveratrol content is preferred for consistency. Co-administration with fats may enhance bioavailability.
FAQs
Is organic grape resveratrol extract more effective than synthetic resveratrol?
No direct comparative RCTs exist; efficacy depends on resveratrol content and bioavailability rather than organic status alone.
How long before benefits are seen?
Molecular and immunological changes may require months to a year of supplementation.
Can it replace medications for inflammation or cardiovascular disease?
No; it may serve as an adjunct but not a replacement for prescribed therapies.
Are there risks of overdose?
High doses may increase risk of side effects; adherence to recommended doses advised.
Research Sources
- https://onlinelibrary.wiley.com/doi/10.1155/2024/5086541 – This systematic review analyzed multiple RCTs on grape products, including resveratrol, and found significant increases in antioxidant agents but no consistent effect on systemic inflammatory markers. It highlights the antioxidant potential of grape products but notes uncertainty in their anti-inflammatory efficacy in general populations. The review suggests that while grape products can boost antioxidant levels, their impact on reducing overall inflammation may be limited.
- https://www.mdpi.com/1422-0067/25/2/747 – This systematic review provides a comprehensive overview of clinical trials using purified resveratrol across various conditions. It confirms antioxidant and metabolic benefits but notes variable effects on inflammation and cardiovascular outcomes. The review emphasizes the need for standardized dosing and long-term studies to fully understand resveratrol's potential. It suggests that while resveratrol shows promise, further research is needed to optimize its use.
- https://www.mdpi.com/2076-3417/14/11/4534 – This study investigates the effects of resveratrol on various health conditions. While the URL provided does not directly lead to a summary, based on the journal and common research themes, it likely explores resveratrol's antioxidant and anti-inflammatory properties. Further investigation of the specific article is needed to provide a more detailed summary of its findings.
- https://onlinelibrary.wiley.com/doi/full/10.1002/fft2.375 – This study likely examines the effects of resveratrol on food and nutrition. While the URL provided does not directly lead to a summary, based on the journal and common research themes, it likely explores resveratrol's antioxidant properties and potential applications in food science. Further investigation of the specific article is needed to provide a more detailed summary of its findings.
- https://pubmed.ncbi.nlm.nih.gov/23557933/ – This one-year randomized, placebo-controlled trial administered 8 mg/day of grape extract containing resveratrol to hypertensive type 2 diabetic patients. The study demonstrated a significant downregulation of pro-inflammatory cytokines and modulation of inflammation-related microRNAs in peripheral blood mononuclear cells. These findings support the immunomodulatory benefits of resveratrol in a high-risk population, with clear statistical significance.
Supplements Containing Organic Grape Resveratrol extract
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