Organic Lime Extract
Also known as: Citrus aurantiifolia extract, Citrus hystrix extract, Citrus latifolia extract, Lime extract, Organic lime extract, Lime peel extract, Lime juice extract
Overview
Organic lime extract is derived from various lime species, including *Citrus aurantiifolia* (Key lime), *Citrus hystrix* (Kaffir lime), and *Citrus latifolia* (Persian lime). It is a source of bioactive compounds like flavonoids (hesperidin, naringenin), limonoids, essential oils (limonene, citral), vitamin C, and pectin. Primarily used as a dietary supplement and functional food ingredient, lime extract is often associated with weight management, lipid control, and antioxidant support. Research on citrus fruits and their extracts is relatively mature, with several systematic reviews and meta-analyses available. However, direct studies focusing specifically on lime extract are somewhat limited, although the broader citrus extract research is generally considered robust and applicable. Standardized extracts may focus on specific compounds to ensure consistent potency and effects.
Benefits
Meta-analyses of citrus extracts, including lime, have demonstrated significant reductions in body weight (−1.28 kg, 95% CI: −1.82 to −0.74, p < 0.001), BMI (−0.32 kg/m², 95% CI: −0.60 to −0.05, p = 0.022), and waist circumference (−2.19 cm, 95% CI: −3.80 to −0.57, p = 0.008) in adults over at least 4 weeks [1]. Secondary benefits include improved lipid profiles, such as reductions in total cholesterol and LDL, along with antioxidant and anti-inflammatory effects [5][3]. These benefits are most pronounced in adults with overweight or obesity. The observed effect sizes are modest but statistically significant for weight and metabolic parameters, typically appearing after 4 weeks of consistent supplementation.
How it works
Lime extract's mechanism of action involves modulating lipid metabolism, enhancing antioxidant defenses, and reducing inflammation [5][3]. It primarily affects the digestive, metabolic, and cardiovascular systems. Flavonoids and limonoids in lime extract inhibit enzymes involved in lipid synthesis and oxidative stress pathways. Essential oils may also play a role by modulating gut microbiota and reducing inflammation. The bioavailability of these compounds varies; flavonoids and limonoids are generally well-absorbed, while essential oils may have lower systemic absorption but exert local effects.
Side effects
Citrus extracts, including lime, are generally considered safe for most adults at typical dietary and supplemental doses. Common side effects are rare, but some individuals may experience mild gastrointestinal discomfort. Uncommon side effects (1-5%) include allergic reactions and photosensitivity, particularly with high doses of essential oils. Rare side effects (<1%) include severe allergic reactions and, extremely rarely, hepatotoxicity. Lime extract may interact with drugs metabolized by CYP3A4 due to its flavonoid content; consultation with a healthcare provider is advised for individuals on medications. Contraindications include allergy to citrus and caution in individuals with photosensitivity or liver disease. While generally safe for most adults, there is insufficient data for pregnant or breastfeeding women, and caution is advised for use in children.
Dosage
While a minimum effective dose for lime extract specifically is not well-established, studies on citrus extracts typically use doses equivalent to 500–1000 mg/day of a standardized extract or 1–2 whole fruits. An optimal dosage range is generally considered to be 500–1000 mg/day of a standardized citrus extract, as higher doses may not provide additional benefits. There is no established upper limit, but excessive intake should be avoided due to the potential for gastrointestinal upset or photosensitivity. Lime extract can be taken with meals to enhance absorption and reduce gastrointestinal discomfort. Standardized extracts are preferred for consistency, while whole fruit or juice may provide additional nutrients but less predictable dosing. Absorption is enhanced with food, and fat-soluble compounds may benefit from dietary fat.
FAQs
Is lime extract safe?
Lime extract is generally safe and well-tolerated. Start with lower doses if you are sensitive to citrus. Discontinue use if you experience any adverse reactions.
When should I take lime extract?
Take lime extract with meals for best absorption and tolerance. Consistent timing can also help maintain steady levels of its active compounds in your system.
What results can I expect from taking lime extract?
You may experience modest improvements in weight, BMI, and lipid profiles after 4 weeks. Individual results can vary based on diet, exercise, and overall health.
Can lime extract cause allergic reactions?
Allergic reactions are rare but possible. Discontinue use immediately if you experience a rash, itching, swelling, or difficulty breathing.
Is lime extract a miracle weight loss supplement?
No, lime extract is not a 'miracle' weight loss supplement. Its effects are modest and should be part of a comprehensive lifestyle approach including diet and exercise.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/32182635/ – This meta-analysis of 13 studies with 921 adults found that citrus extracts significantly reduced body weight, BMI, and waist circumference over at least 4 weeks. The study used a modified Jadad scale and found no publication bias, suggesting high reliability in its findings, although it noted high heterogeneity among the included studies.
- https://www.sciencedirect.com/science/article/abs/pii/S2405457723000396 – This systematic review and meta-analysis examined the effects of citrus extracts on dyslipidemia, finding consistent reductions in total cholesterol and LDL levels across multiple preclinical and clinical studies. While the methodology was robust, the review noted moderate to high heterogeneity among the studies and highlighted the limited number of direct RCTs focusing specifically on lime extract.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC5491624/ – This review article discusses the multiple health benefits of citrus plants and extracts, including weight management, lipid control, and antioxidant effects. It provides a comprehensive overview of available evidence from meta-analyses and clinical trials, emphasizing the need for more research specifically focused on lime.
- https://www.sciencedirect.com/science/article/pii/S2666154324004216 – This research explores the potential of citrus flavonoids in managing obesity and related metabolic disorders. It highlights the mechanisms by which these compounds can influence lipid metabolism and reduce inflammation, contributing to overall metabolic health.
- https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.822678/full – This study investigates the impact of citrus flavonoids on cardiovascular diseases, focusing on their antioxidant and anti-inflammatory properties. It provides insights into how these compounds can protect against heart-related conditions by improving vascular function and reducing oxidative stress.
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