organic Lycii berry extract
Also known as: Goji berry, wolfberry, Lycii berry, organic Lycii berry extract, Lycium barbarum
Overview
Lycium barbarum, commonly known as Goji berry or wolfberry, is a fruit native to East Asia, traditionally valued in Chinese medicine. Organic Lycii berry extract is a concentrated preparation derived from these berries, often standardized for its rich content of bioactive compounds, particularly Lycium barbarum polysaccharides (LBP), carotenoids, and flavonoids. This extract is primarily used as a functional food supplement due to its potential roles in immune modulation, antioxidative support, metabolic regulation, and cardiovascular health. Research indicates its utility in improving lipid profiles and reducing oxidative stress, with moderate-quality evidence from randomized controlled trials and meta-analyses supporting these benefits. While generally considered safe, ongoing research aims to further solidify its clinical applications and optimal usage.
Benefits
Organic Lycii berry extract offers several evidence-based benefits, primarily in metabolic and cardiovascular health. A meta-analysis of 6 RCTs (n=309) demonstrated significant improvements in lipid profiles, including reductions in total cholesterol and triglycerides, and increases in HDL cholesterol, particularly in individuals with metabolic syndrome or type 2 diabetes. These benefits were observed over intervention periods ranging from 4 to 16 weeks. Another systematic review and meta-analysis further supported its role in cardiovascular risk reduction by improving blood lipids and lowering oxidative stress markers. Beyond these primary effects, the extract exhibits secondary benefits such as immune modulation and antioxidative properties, largely attributed to its polysaccharide content. Potential neuroprotective and anti-inflammatory effects have also been suggested, though these are mainly supported by preclinical and smaller clinical studies. While ocular health and mental well-being benefits are indicated, more robust clinical trials are needed to confirm these effects. The evidence quality is moderate, with statistically significant improvements reported in lipid parameters (p < 0.05) across various adult populations.
How it works
The primary mechanism of action for Lycii berry extract is attributed to its bioactive polysaccharides (LBP), which exert potent antioxidative, anti-inflammatory, and immunomodulatory effects. These compounds interact with various biological pathways to reduce oxidative stress by scavenging free radicals and enhancing endogenous antioxidant enzyme activity. LBP also modulates lipid metabolism, influencing enzymes and pathways involved in cholesterol and triglyceride synthesis and breakdown, leading to improved lipid profiles. Furthermore, LBP can influence glucose metabolism and exert anti-inflammatory effects by modulating inflammatory cytokines. While polysaccharides are partially absorbed, their systemic effects are thought to be mediated through immune system modulation and direct antioxidant activity, contributing to overall cellular protection and metabolic balance.
Side effects
Organic Lycii berry extract is generally considered safe and well-tolerated, with a low incidence of adverse effects reported in clinical trials. No significant safety concerns or common side effects have been documented in randomized controlled trials lasting up to 16 weeks. However, caution is advised regarding potential interactions with certain medications. Although no major drug interactions are definitively established, theoretical interactions exist with immunosuppressants and anticoagulants, warranting careful monitoring if co-administered. Specific contraindications are not well-established, but due to a lack of sufficient data, its use in pregnant and lactating women is not recommended. Most studies have been conducted in healthy adults or those with mild to moderate metabolic conditions, so data on special populations or individuals with severe comorbidities are limited. Overall, the safety profile appears favorable for general adult use within recommended dosages.
Dosage
Effective dosages of Lycii berry extract vary depending on the preparation and standardization. For dried wolfberry fruit, typical dietary intake ranges from 10–30 grams per day. When using LBP capsules or fruit juice standardized for polysaccharide content, doses commonly range from 300 mg to 1 gram of polysaccharides per day. These dosages have shown benefits in clinical trials over intervention periods of 4 to 16 weeks. An optimal dose has not been definitively established, but consistency in daily intake is recommended rather than specific timing. Absorption of polysaccharides may be moderately enhanced when taken with food. There are no specific cofactors required to maximize its efficacy. It is important to note that these dosages are based on research and individuals should consult a healthcare professional for personalized advice, especially if they have underlying health conditions or are taking other medications.
FAQs
Is organic Lycii berry extract safe?
Yes, clinical trials indicate a good safety profile with minimal side effects, making it generally safe for consumption within recommended dosages.
How soon can benefits be expected?
Improvements in lipid profiles and oxidative stress markers are typically observed within 4 to 16 weeks of consistent supplementation.
Can it replace medications for cholesterol or diabetes?
No, Lycii berry extract should not replace prescribed medications. It may serve as an adjunct therapy, but always consult your doctor.
Are all Lycii berry extracts equal?
No, the bioactivity varies. Extracts standardized for polysaccharide content are generally preferred for consistent and reliable effects.
Research Sources
- https://pmc.ncbi.nlm.nih.gov/articles/PMC10545344/ – This systematic review and meta-analysis of 6 RCTs (n=309) found that Lycium barbarum significantly improved lipid profiles (total cholesterol, triglycerides, HDL) in individuals with metabolic syndrome, type 2 diabetes, and healthy adults over 4-16 weeks, indicating its potential for cardiovascular health.
- https://pubmed.ncbi.nlm.nih.gov/34839399/ – This systematic review and meta-analysis concluded that wolfberry consumption contributes to reduced cardiovascular risk by improving blood lipid parameters and decreasing oxidative stress markers, supporting its role in cardiovascular health management.
- https://onlinelibrary.wiley.com/doi/10.1155/2019/4615745 – This systematic review of LBP's therapeutic potential, including two RCTs, highlights its antioxidative, anti-inflammatory, and neuroprotective properties. It suggests promising applications for liver disease, diabetes, and hyperlipidemia, though it notes the need for more extensive clinical trials.
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