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Organic Nitric Oxide Blend

Also known as: Nitric oxide, NO, Nitric oxide boosters, NO precursors, L-arginine, L-citrulline, Dietary nitrates, Nitric Oxide

Overview

Nitric oxide (NO) is a molecule crucial for vascular dilation and neurotransmission, often supplemented via precursors like L-arginine, L-citrulline, and dietary nitrates. These supplements, commonly referred to as nitric oxide boosters, are used primarily to enhance cardiovascular health and exercise performance. Natural sources of nitrates include beetroot and leafy greens. NO works by improving blood flow, which can increase oxygen delivery to muscles, potentially benefiting exercise endurance and reducing fatigue. Research on NO supplements is moderately mature, with strong evidence supporting exercise performance benefits. However, long-term health benefits require further investigation. These supplements are available in various forms, including capsules, powders, and liquids, with L-citrulline often preferred due to its superior bioavailability compared to L-arginine.

Benefits

Nitric oxide supplementation primarily improves exercise performance by reducing fatigue and enhancing endurance, with a small but statistically significant effect size (Cohen's d = 0.174). Untrained or moderately trained individuals may experience more pronounced benefits. Secondary benefits include potential improvements in cardiac health and reducing high blood pressure during pregnancy, although evidence for these is less robust. The benefits are typically observed within hours of supplementation, making it suitable for pre-workout use. While some studies suggest potential benefits for body composition, the evidence remains limited.

How it works

Nitric oxide supplements work through both nitric oxide synthase-dependent and -independent pathways. These pathways convert precursors like L-arginine and L-citrulline into NO, which then enhances vascular dilation and blood flow. This increased blood flow affects the cardiovascular, muscular, and nervous systems, improving oxygen and nutrient delivery to muscles and enhancing neurotransmission. The primary molecular targets are endothelial cells and smooth muscle cells in blood vessels, where NO promotes relaxation and widening of the vessels.

Side effects

Nitric oxide supplements are generally safe when used appropriately, but they can cause side effects in some individuals. Common side effects (occurring in more than 5% of users) include gastrointestinal issues such as diarrhea or stomach discomfort. Uncommon side effects (1-5%) may include headaches and dizziness. Rare side effects (less than 1%) can involve allergic reactions. These supplements may interact with blood thinners and medications for erectile dysfunction. They are contraindicated in pregnancy and breastfeeding without medical supervision. Caution is advised for individuals with pre-existing medical conditions or those taking specific medications.

Dosage

The minimum effective dose typically starts at 1-2 grams of L-arginine or 2-3 grams of L-citrulline per day. Optimal dosage ranges for L-citrulline with malate are around 3-6 grams for exercise performance. While a maximum safe dose is not firmly established, high doses may increase the risk of side effects. For exercise performance benefits, it is recommended to take the supplement 30 minutes to 1 hour before exercise. Citrulline malate is often preferred for exercise performance. Absorption may be influenced by stomach pH and food intake. No specific cofactors are required for nitric oxide synthesis from these precursors.

FAQs

How long does it take to see benefits?

Benefits from nitric oxide supplementation, such as improved exercise performance, are typically observed within hours of consumption.

Is it safe for everyone?

Nitric oxide supplements are generally safe, but it's best to consult a doctor if you have pre-existing medical conditions or are taking medications.

When is the best time to take it?

For exercise performance enhancement, it is best to take nitric oxide supplements 30-60 minutes before your workout.

What results can I expect?

You can expect improved exercise performance and potential cardiovascular benefits. Evidence suggests minimal impact on body composition.

Research Sources

https://pmc.ncbi.nlm.nih.gov/articles/PMC7494956/ – This systematic review and meta-analysis found that nitrate supplementation improves exercise performance, demonstrating a small but statistically significant effect size (Cohen's d = 0.174). The study highlights the potential of dietary nitrates to enhance endurance and reduce fatigue during physical activity.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9710401/ – This review highlights the benefits of nitric oxide supplementation for cardiac health and exercise performance, particularly in untrained individuals. The findings suggest that NO supplementation can improve cardiovascular function and enhance exercise capacity in those with limited training experience.
https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2022.953912/full – This meta-analysis showed that exercise training significantly increases nitric oxide levels, which may enhance performance. The study suggests that regular physical activity can naturally boost NO production, leading to improved physiological function and exercise outcomes.
https://pubmed.ncbi.nlm.nih.gov/36771366/ – This study investigates the impact of citrulline supplementation on nitric oxide production and its subsequent effects on various physiological parameters. The research provides insights into the efficacy of citrulline as a precursor for NO synthesis and its potential applications in enhancing health and performance.
https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/effects-of-beetroot-and-nitrate-supplementation-on-body-composition-a-gradeassessed-systematic-review-and-metaanalysis/949832E60B3818D6D849353FC0B117FE – This systematic review and meta-analysis assesses the effects of beetroot and nitrate supplementation on body composition. The findings indicate that while nitrate supplementation may improve exercise performance, its impact on body composition is minimal, suggesting that it is not a significant factor in weight management or muscle building.