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Organic Olive Leaf

Also known as: Olea europaea L. (leaf), Olive leaf, Olive leaf extract (OLE), Olive leaf powder, Olea europaea (leaf)

Overview

Olive leaf is derived from the leaves of the olive tree (*Olea europaea* L.), a plant native to the Mediterranean region. It is primarily used to support cardiovascular health, manage blood pressure, and provide antioxidant benefits. The key characteristic of olive leaf is its high concentration of polyphenols, particularly oleuropein, which exhibits significant antioxidant and anti-inflammatory properties. Olive leaf extract is available in various forms, including capsules, powders, and liquid extracts, with standardized extracts preferred for consistent polyphenol content. Research on olive leaf is considered to be at a moderate level, with several randomized controlled trials and systematic reviews available. However, the quality of evidence is limited by heterogeneity and risk of bias in some studies. The strongest evidence supports its effects on blood pressure and lipid profiles, though further research is needed to confirm these findings and explore other potential benefits.

Benefits

Olive leaf extract demonstrates several evidence-based benefits, primarily related to cardiovascular health. Meta-analyses have shown a significant reduction in systolic blood pressure (SBP) by -0.87 mmHg (95% CI: -1.09, -0.64) and diastolic blood pressure (DBP) by -0.39 mmHg (95% CI: -0.57, -0.21). Additionally, it has been shown to reduce total cholesterol (-0.52 mmol/L; 95% CI: -0.81, -0.22), LDL-C (-0.35 mmol/L; 95% CI: -0.58, -0.12), and triglycerides (-0.67 mmol/L; 95% CI: -1.19, -0.16). Some studies suggest greater improvements in triglycerides, SBP, DBP, total cholesterol, and LDL-C in individuals with hypertension and normal body weight. While olive leaf extract also exhibits antioxidant and anti-inflammatory effects in vitro and in some human studies, these effects are not consistently significant in meta-analyses. The clinical relevance of the observed blood pressure and lipid reductions may be modest, but potentially meaningful in at-risk populations. Effects on blood pressure and lipids are typically observed within 4–12 weeks of supplementation.

How it works

Olive leaf extract exerts its effects through several biological pathways. Its antioxidant properties are attributed to its high polyphenol content, which scavenges free radicals. It also exhibits anti-inflammatory effects by modulating inflammatory cytokines. Furthermore, olive leaf extract enhances nitric oxide bioavailability, leading to vasodilation and improved endothelial function. In terms of lipid metabolism, it may inhibit cholesterol synthesis and absorption. Oleuropein, a major bioactive compound in olive leaf, inhibits angiotensin-converting enzyme (ACE) and reduces oxidative stress. Hydroxytyrosol, another key component, is a potent antioxidant and anti-inflammatory agent. Oleuropein and hydroxytyrosol are well-absorbed, with metabolites detectable in plasma and urine.

Side effects

Olive leaf extract is generally well-tolerated in clinical studies. The most commonly reported side effect is mild gastrointestinal discomfort, although this is rare. Uncommon side effects, occurring in 1-5% of users, include headache and dizziness. Allergic reactions are rare. Olive leaf extract may have additive effects with antihypertensive and lipid-lowering medications, so caution is advised when used in combination with these drugs. It is contraindicated in individuals with hypersensitivity to olive products. Due to limited data, use with caution in pregnancy, lactation, and children. Overall, olive leaf extract is considered safe for most individuals when taken at recommended dosages, but monitoring for potential drug interactions and allergic reactions is warranted.

Dosage

The minimum effective dose of olive leaf extract is 500 mg/day, standardized to an oleuropein content of typically 10–20%. Optimal dosage ranges are between 500–1000 mg/day, divided into multiple doses. While clinical studies have used doses up to 2000 mg/day, this is not routinely recommended. It is best to take olive leaf extract with meals to enhance absorption and reduce potential gastrointestinal discomfort. Standardized extracts are preferred to ensure consistent polyphenol content. Food intake enhances the absorption of olive leaf extract's active compounds. No specific cofactors are required for its effectiveness. Individuals taking antihypertensive or lipid-lowering medications should monitor their blood pressure and lipid levels closely when starting olive leaf extract supplementation.

FAQs

Is olive leaf extract safe?

Olive leaf extract is generally safe for most people. Mild side effects like stomach upset are rare. If you take blood pressure meds, monitor your blood pressure.

When should I take olive leaf extract?

Take olive leaf extract with meals to help your body absorb it better and to avoid stomach upset. Consistency is key for seeing results.

How long does it take to see results?

You might notice modest improvements in blood pressure and cholesterol within 4–12 weeks. Remember, it works best alongside a healthy lifestyle.

Can olive leaf extract replace my medications?

No, olive leaf extract is not a substitute for prescribed medications. It can be a helpful addition, but always follow your doctor's advice.

What are the benefits of olive leaf extract?

Olive leaf extract may help lower blood pressure and improve cholesterol levels. It's also an antioxidant. However, the effects are modest and may vary.

Research Sources

https://pubmed.ncbi.nlm.nih.gov/38287654/ – This systematic review and meta-analysis investigated the effects of olive leaf extract (OLE) on various health markers. The study found that OLE significantly improved triglycerides and systolic blood pressure, particularly in hypertensive and normal-weight individuals. However, it noted limitations such as heterogeneity, risk of bias, and limited data on oleuropein content, leading to a moderate to low quality of evidence for most outcomes.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9585795/ – This systematic review confirmed the beneficial effects of olive leaf extract on cardiometabolic risk factors, especially blood pressure and lipids. The review highlights the potential of OLE as a natural supplement for cardiovascular health. However, it also acknowledges the limitations of the existing research, including study heterogeneity and risk of bias, which affect the overall quality of evidence.
https://academic.oup.com/nutritionreviews/article/82/12/1710/7591544?login=false – This systematic review examined the impact of olive leaf extract on blood pressure and lipid profiles. The review found significant reductions in SBP, DBP, total cholesterol, LDL-C, and triglycerides. However, the authors noted that the small sample sizes and short-term nature of the included studies limited the strength of the conclusions, resulting in a moderate quality of evidence.
https://www.journalrip.com/PDF/jrip-11-e31933.pdf – This study focused on the effects of olive leaf extract on blood pressure and other cardiovascular risk factors. The research indicated that OLE could be a beneficial supplement for managing hypertension and improving lipid metabolism. However, the study also pointed out the need for more extensive research with larger sample sizes and longer durations to validate these findings comprehensively.
https://www.mdpi.com/2813-0464/3/3/26 – This research article explores the antioxidant and anti-inflammatory properties of olive leaf extract. The study provides evidence supporting the potential of OLE to reduce oxidative stress and inflammation, which are key factors in various chronic diseases. The findings suggest that OLE could be a valuable natural agent for promoting overall health and preventing disease.