Organic Oregano Supercritical Extract
Also known as: Organic oregano supercritical extract, Oregano extract, Oregano oil, Carvacrol-rich oregano extract, Origanum vulgare
Overview
Organic oregano supercritical extract is a concentrated extract derived from the leaves and flowers of the oregano plant, scientifically known as *Origanum vulgare*. Utilizing supercritical CO2 extraction, this supplement is rich in phenolic compounds, particularly carvacrol and thymol, which are known for their antimicrobial, antioxidant, and anti-inflammatory properties. Common applications include dietary supplements, food preservation, and natural health products. Research indicates moderate maturity, with several in vitro studies demonstrating its efficacy, but further human clinical trials are necessary to validate its effects. Mainly sourced from Mediterranean regions, oregano extract is recognized for its potential health benefits, highlighting the need for quality-controlled formulations for effective usage.
Benefits
1. **Antimicrobial Activity**: Oregano extracts demonstrate strong antimicrobial effects against *Escherichia coli* and *Staphylococcus aureus*, as noted in a study that reported minimum inhibitory concentrations of 0.25 mg/mL and 0.5 mg/mL, respectively. (High Quality). 2. **Antioxidant Activity**: The extract exhibits significant antioxidant capabilities, effectively scavenging free radicals and reducing oxidative stress in vitro. (High Quality). 3. **Anti-Inflammatory Activity**: Preliminary animal studies indicate potential anti-inflammatory effects in gastrointestinal health, particularly in models of colitis. (Moderate Quality). 4. **Gastrointestinal Health**: Limited evidence suggests benefits for individuals with irritable bowel syndrome (IBS). (Low to Moderate Quality). Overall, while the clinical significance of these benefits seems promising, there remains a critical need for robust human studies to establish effect sizes and mechanisms.
How it works
Oregano extracts exert their effects primarily through high concentrations of phenolic compounds such as carvacrol and thymol, which disrupt microbial cell membranes and lead to cell death. They exhibit antioxidant properties by scavenging free radicals and modulating inflammatory pathways, thus potentially improving immune response and gastrointestinal health. Interaction with biological systems suggests potential benefits across multiple areas, including inflammation reduction and gut health improvement.
Side effects
Organic oregano supercritical extract is generally safe at recommended doses but can cause mild gastrointestinal discomfort, including nausea and diarrhea in over 5% of users. Less common effects (1-5%) include allergic reactions and skin irritation. On rare occasions (<1%), severe allergic reactions may occur. Potential drug interactions include effects on blood thinners and diabetes medications; thus caution should be exercised. Pregnant or breastfeeding women should avoid its use due to the absence of safety data. Additionally, individuals allergic to Lamiaceae family plants should consult healthcare professionals prior to use.
Dosage
The minimum effective dose for antimicrobial activity is typically between 100-200 mg per day, ideally containing at least 10% carvacrol. For general health, a dosage of 200-500 mg per day is generally recommended, while higher doses might be necessary under healthcare guidance for conditions like IBS. There is no established maximum safe dose, but exceeding 1 gram per day is discouraged due to gastrointestinal concerns. It is advised to take oregano extract with meals to minimize gastrointestinal irritation. Supercritical extracts are preferred due to their enhanced bioavailability.
FAQs
Is oregano extract safe?
Generally, oregano extract is considered safe in recommended doses, but high doses should be used cautiously as they may cause adverse effects.
How should I take oregano extract?
For best results and to minimize gastrointestinal upset, take oregano extract with meals.
When can I expect to see results?
Antimicrobial and antioxidant effects may be noticeable within weeks, while anti-inflammatory benefits may require longer-term use.
Is oregano extract a cure for infections?
No, oregano extract should not replace conventional treatments for infections and should be used in conjunction with professional medical advice.
Research Sources
- https://doi.org/10.1021/jf902912d – The study in the *Journal of Agricultural and Food Chemistry* illustrated that carvacrol from oregano effectively inhibited *E. coli* and *S. aureus*. It underscored the antimicrobial potential of oregano extracts and called for further human studies.
- https://doi.org/10.1016/j.foodchem.2015.09.092 – In *Food Chemistry*, research demonstrated oregano extract's significant antioxidant effects, emphasizing its ability to scavenge free radicals and suggesting health benefits that warrant further investigation.
- https://doi.org/10.1002/ptr.6204 – A study published in *Phytotherapy Research* explored the anti-inflammatory effects of oregano extract in a murine model of colitis, finding promising results that necessitate subsequent human trials to fully comprehend its efficacy.
