ovine spleen
Also known as: Sheep Spleen Extract, Ovine Spleen Extract
Overview
Ovine spleen extract is a dietary supplement derived from the spleens of sheep (Ovis aries). The spleen is a vital secondary lymphoid organ responsible for immune function and blood filtration. These supplements are primarily marketed for their purported ability to support the immune system, and are sometimes suggested for conditions such as autoimmune disorders, blood diseases, kidney ailments, and post-splenectomy recovery. The underlying principle for its use is rooted in 'organotherapy,' a traditional belief that consuming animal organ tissue can support the corresponding human organ. Ovine spleen extract is a complex mixture containing various proteins, immune cells, and bioactive molecules, though its exact composition can vary significantly based on processing methods. Research into its efficacy and safety is currently limited and preliminary, consisting mostly of animal studies and transcriptomic analyses rather than robust human clinical trials.
Benefits
There is currently no robust clinical data demonstrating clear benefits of ovine spleen supplements in humans. While some animal studies have investigated immune gene expression changes in the spleen following vaccination or stress, these findings do not directly translate to the efficacy of oral ovine spleen supplements in humans. Anecdotal reports and traditional claims suggest immune modulation and support for autoimmune conditions, but these lack rigorous scientific validation. Consequently, no specific benefits, effect sizes, or clinical significance have been established for any human population due to the absence of high-quality randomized controlled trials or systematic reviews.
How it works
The spleen plays a crucial role in immune surveillance, filtering blood, and orchestrating immune responses. Transcriptomic studies in animal spleens have shown gene expression changes related to immune activation in response to stimuli like vaccination or stress. It is theorized that ovine spleen extract might modulate immune system function through its complex mixture of bioactive proteins or peptides. However, the direct effects of orally ingested ovine spleen extract on human immune pathways are unproven. No specific molecular targets have been clearly identified or validated in humans, and the absorption and bioavailability of potential active components after oral ingestion remain uncertain.
Side effects
The overall safety of ovine spleen extract has not been thoroughly assessed in high-quality human studies, and clinical safety data are largely lacking. Consequently, there are no documented common, uncommon, or rare side effects reported in scientific literature. Similarly, no drug interactions or contraindications have been established. Due to the absence of comprehensive safety data, caution is advised, particularly for vulnerable populations such as pregnant women, children, and individuals who are immunocompromised. Users should be aware that the lack of reported side effects does not equate to proven safety, but rather reflects the limited research available.
Dosage
The minimum effective dose, optimal dosage ranges, and maximum safe dose for ovine spleen extract have not been established due to a lack of clinical research. There are no specific timing considerations or form-specific recommendations supported by scientific evidence. Ovine spleen extract is typically available in capsule or powder forms. The absorption factors and any required cofactors for its purported effects are also unknown. Without established dosing guidelines, users should exercise caution and consult with a healthcare professional before use.
FAQs
Is ovine spleen extract effective for immune support?
Currently, there is no high-quality clinical evidence from human studies to support the efficacy of ovine spleen extract for immune support.
Is it safe to take ovine spleen supplements?
Significant safety data from human clinical trials are lacking, so caution is recommended when considering ovine spleen supplements.
How long does it take to see effects?
The time course for any potential effects of ovine spleen extract is unknown due to the absence of human clinical trials.
Can it replace conventional treatments?
No, ovine spleen extract should not be used as a replacement for evidence-based medical therapies or conventional treatments.
Are there any known interactions?
There are no documented drug interactions for ovine spleen extract, but this is likely due to a lack of research rather than confirmed safety.
Research Sources
- https://pmc.ncbi.nlm.nih.gov/articles/PMC11284609/ – This animal study used RNA-seq to profile transcriptomic changes in ovine spleen after repetitive vaccination. It identified immune-related gene expression changes, highlighting the spleen's role in immune response, but did not assess the efficacy or clinical outcomes of ovine spleen as a supplement.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC7288455/ – This animal model study investigated transcriptomic changes in chicken spleen under stress-induced immunosuppression. It provided insights into the molecular mechanisms of immune modulation within the spleen but did not evaluate the efficacy of ovine spleen extract as a supplement.
- https://www.ebsco.com/research-starters/nutrition-and-dietetics/spleen-extract-therapeutic-supplement – This review discusses spleen extract as a therapeutic supplement, noting that evidence for its immune support claims is limited and often outdated. It emphasizes the critical need for rigorous clinical trials and advises cautious interpretation of any purported benefits due to the lack of high-quality human studies.
Supplements Containing ovine spleen

Cardio-Plus
SP Standard Process

Glucosamine Synergy
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Min-Chex
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Zypan
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Catalyn
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Ligaplex I
SP Standard Process

Zypan
SP Standard Process