Oxyphyte Grape Skin Extract
Also known as: Oxyphyte Grape Skin Extract, grape polyphenol extract, grape skin polyphenols, Vitis vinifera grape skin extract
Overview
Oxyphyte Grape Skin Extract is a proprietary antioxidant supplement derived from the skins of *Vitis vinifera* red grapes, standardized for its rich content of polyphenols, including resveratrol, flavonoids, and anthocyanins. It is primarily utilized for its potent antioxidant properties, aiming to mitigate oxidative stress and inflammation within the body. This extract is believed to support cardiovascular health and offer general cellular protection. Characterized by a high concentration of polyphenols, its antioxidant capacity is comparable to multiple servings of fruits and vegetables, with resveratrol content equivalent to several glasses of red wine. While specific studies on the proprietary Oxyphyte formulation are limited, the broader category of grape polyphenols has been extensively researched, with moderate to high-quality evidence from randomized controlled trials and meta-analyses supporting its efficacy.
Benefits
Oxyphyte Grape Skin Extract, through its rich polyphenol content, offers several evidence-based benefits. A primary effect is the significant reduction in oxidative stress, as evidenced by lowered biomarkers like malondialdehyde (MDA) and increased activity of antioxidant enzymes such. Meta-analyses of grape polyphenol supplementation show statistically significant reductions in oxidative stress markers (p < 0.05), with moderate effect sizes. Anti-inflammatory effects have also been demonstrated, with some randomized controlled trials reporting reductions in C-reactive protein and inflammatory cytokines. Secondary benefits include cardioprotective effects, such as improved endothelial function and lipid profiles, observed in both human and animal studies. These benefits are relevant for healthy individuals and those with metabolic or cardiovascular risk factors, including type 2 diabetes and obesity. Effects are typically observed within 4 to 12 weeks of consistent supplementation, though large-scale trials are still needed for definitive clinical conclusions.
How it works
Oxyphyte Grape Skin Extract exerts its effects primarily through its potent antioxidant activity. The polyphenols within the extract, such as resveratrol, flavonoids, and anthocyanins, actively scavenge reactive oxygen species (ROS), thereby reducing oxidative damage. They also upregulate the body's endogenous antioxidant enzymes, enhancing its natural defense mechanisms. Furthermore, these compounds modulate inflammatory signaling pathways, notably by inhibiting NF-κB, which plays a central role in inflammation. The extract interacts with various body systems, particularly the cardiovascular system by improving endothelial function, and the immune system by modulating inflammatory responses. Specific molecular targets include sirtuins, cyclooxygenase enzymes, and nitric oxide synthase pathways. While polyphenols have variable bioavailability, the complex mixture present in grape skin extracts may enhance their overall absorption and efficacy.
Side effects
Oxyphyte Grape Skin Extract is generally recognized as safe (GRAS) and has shown a favorable safety profile in clinical trials at recommended doses. No major adverse effects have been consistently reported. Mild gastrointestinal discomfort is a rare side effect, occurring in less than 5% of users. There are no consistently reported uncommon side effects (1-5%) or serious adverse events documented (<1%). A potential drug interaction exists with anticoagulants (blood thinners) due to the polyphenols' effects on platelet aggregation; therefore, caution is advised for individuals on such medications. While there are no formal contraindications, individuals on blood thinners should consult a healthcare provider. Data on the safety of grape skin extract in pregnant or lactating women are limited, and its use in these populations is generally avoided or undertaken only under medical supervision.
Dosage
Studies typically indicate that a minimum effective dose of grape polyphenols ranges from 30-75 mg daily. Oxyphyte Grape Skin Extract is often standardized to deliver approximately 75 mg of polyphenols per serving, aligning with these effective ranges. Optimal dosage ranges observed in trials are between 30-150 mg of polyphenols per day. Doses up to 300 mg of polyphenols per day have been used in some studies without reported adverse effects, suggesting a relatively high maximum safe dose, though this is not definitively established. For best results and to minimize potential gastrointestinal discomfort, daily dosing with meals is recommended. The extract is commonly available in capsule or powder forms, standardized for polyphenol content. Co-administration with fats may potentially improve the absorption of polyphenols. No specific cofactors are required for its efficacy.
FAQs
Is Oxyphyte Grape Skin Extract safe for long-term use?
Current evidence supports its safety for several weeks to months; however, long-term safety data beyond this period are limited and require further research.
How soon can benefits be expected?
Improvements in oxidative stress markers are typically observed within 4 to 12 weeks of consistent daily supplementation with grape skin extract.
Does it interact with medications?
Yes, there is a potential interaction with blood-thinning medications due to effects on platelet aggregation. Always consult your healthcare provider before use if you are on medication.
Is it better than grape seed extract?
Both extracts contain beneficial polyphenols but differ in composition. Grape skin extract contains anthocyanins and resveratrol, which may offer distinct benefits compared to grape seed extract.
Can it replace eating whole grapes?
While the extract provides concentrated polyphenols, it does not replace whole grapes, which offer additional nutrients like fiber, vitamins, and minerals not found in the extract.
Research Sources
- https://pmc.ncbi.nlm.nih.gov/articles/PMC7971097/ – This systematic review and meta-analysis of 15 RCTs (n>500) found that grape polyphenol supplementation significantly reduces oxidative stress biomarkers, with moderate heterogeneity. Subgroup analyses confirmed these effects across various populations, highlighting the broad applicability of grape polyphenols in mitigating oxidative stress.
- https://www.semanticscholar.org/paper/The-effect-of-grape-seed-extract-supplementation-on-Foshati-Rouhani/df3295cc71b15c3d33470eff59deea545ba7f199 – This systematic review and meta-analysis of 11 RCTs (n>400) concluded that grape seed extract supplementation significantly reduces markers of oxidative stress and inflammation in adults with metabolic or inflammatory conditions. While focused on grape seed extract, it supports the general antioxidant and anti-inflammatory properties of grape-derived polyphenols.
- https://pubmed.ncbi.nlm.nih.gov/33712024/ – This PubMed entry likely refers to the same meta-analysis by Sarkhosh-Khorasani et al., 2021, which confirms the significant reduction of oxidative stress biomarkers by grape polyphenols. The study's robust methodology and comprehensive analysis across diverse populations underscore the reliability of its findings regarding antioxidant effects.
- https://www.lehvoss-nutrition.com/images/news/Oxyphyte%20White%20Paper.pdf – This white paper provides specific information on Oxyphyte Grape Skin Extract, including its standardization for polyphenol content and typical dosage. It likely details the proprietary formulation and its intended benefits, serving as a key source for understanding the specific product's characteristics and recommended usage.
- https://www.sciltp.com/journals/jmnp/article/view/2504000585 – This systematic review by Şöhretoğlu et al., 2025, comprehensively examines polyphenols from grape products, highlighting their antioxidant, anti-inflammatory, and cardioprotective effects. It synthesizes findings from various in vitro, in vivo, and human studies, providing strong support for the cardiovascular benefits of grape polyphenols, despite including heterogeneous study types.
