Paeonia Suffruticosa Root Bark Extract
Also known as: Tree Peony, Moutan Cortex, Paeonia suffruticosa root bark extract, Paeonia suffruticosa
Overview
*Paeonia suffruticosa* root bark extract is derived from the root bark of the Tree Peony, a plant with significant historical usage in traditional Chinese medicine. Primarily, it is utilized to address female genital issues, cardiovascular diseases, and blood stagnation disorders. This extract features various bioactive compounds such as monoterpenes, glycosides, triterpenes, phenolics, and flavonoids, which contribute to its therapeutic effects. While the research is moderate, it highlights the traditional applications and emerging insights into its pharmacological properties. However, the number of high-quality clinical trials remains limited, posing challenges for affirmative conclusions on efficacy.
Benefits
Research has identified multiple potential benefits of *Paeonia suffruticosa*, including antioxidant, anti-inflammatory, antibacterial, antiviral, antitumor, and neuroprotective properties. Preclinical studies suggest these effects, with specific benefits for individuals dealing with cardiovascular or neurodegenerative conditions. Although traditional uses point towards its efficacy in these areas, clinical evidence to quantify and substantiate these claims is still needed. Notably, the effect sizes and clinical significance in human studies remain unquantified, underscoring the necessity for further investigation.
How it works
*Paeonia suffruticosa* is believed to exert its health-promoting effects through antioxidant and anti-inflammatory pathways attributed to its rich composition of phenolic and flavonoid compounds. These compounds may interact beneficially with cardiovascular and nervous systems; although specific molecular targets and detailed mechanisms remain under-researched. Given the limited understanding of absorption and bioavailability, more research is required to illuminate how these interactions occur in the body.
Side effects
While *Paeonia suffruticosa* is typically regarded as safe in traditional contexts, modern research indicates a lack of comprehensive safety data. Common side effects have not been well documented, and there are no reports of unusual or rare adverse effects. Nevertheless, caution is advised regarding potential interactions with cardiovascular medications due to its impact on blood circulation. Additionally, given the limited safety data, pregnant and lactating individuals should consult healthcare professionals before use. Overall, thorough research into its side effect profile and drug interactions is warranted.
Dosage
The minimum effective dose for *Paeonia suffruticosa* has not been established, and optimal dosages remain undefined. Because the extract is usually administered in various forms, including standardized extracts, precise dosage recommendations vary. There is currently no upper limit or maximum safe dose identified. Timing considerations and factors affecting absorption also remain unexamined; thus, consulting a healthcare professional before use is advisable to tailor the dosage to individual needs.
FAQs
What should I consider before using *Paeonia suffruticosa*?
Consult a healthcare provider if you're on medications or have underlying health conditions, especially cardiovascular issues.
Is it safe to use during pregnancy?
Modern safety data is limited, hence caution is advised during pregnancy and lactation.
What are the expected results from taking this extract?
Effects can vary based on the condition treated; further clinical evidence is required for concrete expectations.
Are there any known drug interactions?
Potential interactions may occur with cardiovascular medications; it's essential to seek professional advice.
Is there scientific proof for its traditional uses?
While traditional usage is well-documented, clinical studies validating efficacy are limited.
Research Sources
- https://www.cir-safety.org/sites/default/files/PaeoniaSuffruticosa.pdf – This review comprehensively outlines the historical and traditional uses of *Paeonia suffruticosa*, highlighting its potential health benefits and bioactive compounds, though it notes a lack of clinical trial data.
- https://pubmed.ncbi.nlm.nih.gov/36822345/ – This in vitro study investigated the cytotoxic effects of *Paeonia suffruticosa* extract on human bladder cancer cells, revealing significant cytotoxicity at specific concentrations, necessitating further research into in vivo applications.
- https://ouci.dntb.gov.ua/en/works/7BjXRLJ7/ – A safety assessment conducted on mice indicates low oral toxicity of *Paeonia suffruticosa*, noting no significant changes in body weight, but emphasizes the need for more human-focused research.