Pelargonium Sidoides Extract
Also known as: Umckaloabo, African Geranium, Black Pelargonium, *Pelargonium sidoides*
Overview
*Pelargonium sidoides* is a medicinal plant native to South Africa, valued for its therapeutic properties, particularly in respiratory health. The extract derived from this plant, often branded as EPs 7630, has a history of use in treating respiratory infections and is known for its antimicrobial and immunomodulatory effects. It has been traditionally utilized to alleviate symptoms associated with acute respiratory tract infections (ARIs), including acute bronchitis, the common cold, and sinusitis. Research surrounding its efficacy is moderate, with a number of clinical trials indicating its benefits; however, the quality of evidence varies significantly among studies. The extract is available in various forms, including tablets and liquid formulations, and is regarded as a safe option for symptomatic relief in many populations.
Benefits
Research supports several benefits of *Pelargonium sidoides* extract, particularly in treating acute bronchitis and the common cold. In clinical studies, approximately 88.7% of adults taking EPs 7630 reported a significant reduction of cough intensity, with an effect size showing a five-fold increase in the probability of symptom relief compared to placebo. Additionally, improvements in overall quality of life, as evidenced by the ability to resume daily activities, have been documented. While findings are generally supportive in both adults and children, the heterogeneity of studies and some methodological limitations contribute to a categorization of evidence as low to moderate overall.
How it works
*Pelargonium sidoides* functions primarily through its antimicrobial and antiadhesive properties, helping to alleviate symptoms of respiratory infections. It is thought to interact with the respiratory and immune systems, mediating inflammation and modulating immune response. Studies suggest various pathways are affected, though specific molecular targets remain to be fully characterized. The bioavailability of the extract is not well documented, limiting detailed understanding of its pharmacokinetics.
Side effects
The safety profile for *Pelargonium sidoides* is generally favorable, with no serious adverse events reported in clinical studies. Common adverse effects include gastrointestinal discomfort such as nausea and diarrhea, occurring in more than 5% of users. Mild allergic reactions may occur at rates of 1-5%, while rare side effects are not well documented. Caution is recommended when used alongside other medications, although no significant drug interactions have been noted. Due to insufficient safety data, *Pelargonium sidoides* is contraindicated during pregnancy and breastfeeding. Care is advised when giving this extract to children under 6 years of age.
Dosage
The minimum effective dose of *Pelargonium sidoides* is typically 30 mg of EPs 7630 per day, with optimal dosing ranges between 30-60 mg daily depending on the formulation, whether liquid or tablets. Doses above 60 mg are rarely studied and considered not well-established. Administration is most effective when initiated at the onset of symptoms, ideally taken with food to reduce gastrointestinal side effects. Specific absorption factors remain understudied, and co-factors or adjunctive treatments have not been identified.
FAQs
How should I take *Pelargonium sidoides* for best results?
It is recommended to start treatment early at the onset of symptoms, ideally with food to minimize gastrointestinal side effects.
Is *Pelargonium sidoides* safe for everyone?
While generally safe, caution is advised for pregnant or breastfeeding women and children under 6 due to limited safety data.
What results can I expect from taking *Pelargonium sidoides*?
Most users experience symptom relief within 7-10 days of starting treatment, particularly for cough and respiratory discomfort.
Is *Pelargonium sidoides* a cure for infections?
No, it is not a cure but a supportive treatment aimed at alleviating symptoms of respiratory infections.
Can I take *Pelargonium sidoides* with other medications?
While no significant interactions are reported, consult a healthcare provider for advice on concurrent use with other medications.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/18222667/ – A systematic review and meta-analysis of studies indicated that *Pelargonium sidoides* significantly reduces bronchitis symptom scores compared to placebo, with moderate evidence quality due to variability in study methodologies.
- https://pubmed.ncbi.nlm.nih.gov/24146345/ – This review analyzed ten studies focusing on adults and children with ARIs, concluding that *Pelargonium sidoides* may alleviate symptoms of acute bronchitis and sinusitis, though evidence quality varied.
- https://mrmjournal.org/index.php/mrm/article/view/868 – A meta-analysis encompassing 2,195 participants found that EPs 7630 reduces cough intensity and enhances quality of life measures, but noted limitations in study quality affecting the findings.
- https://pubmed.ncbi.nlm.nih.gov/39654721/?fc=None&ff=20241210073559&v=2.18.0.post9+e462414 – The review found that *Pelargonium sidoides* offers significant advantages in treating cough associated with acute bronchitis, highlighting improvements over placebo in symptom relief.
- https://pelargonium.org/information-for-healthcare-practitioners/systematic-reviews-meta-analyses/ – This source compiles systematic reviews and meta-analyses concerning *Pelargonium sidoides*, summarizing a body of literature suggesting efficacy, albeit with a caution for methodological quality and heterogeneity.
