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Peptistrong

Also known as: PeptiStrong®, fava bean peptides, PeptiStrong

Overview

PeptiStrong® is a hydrolysate derived from fava bean protein, comprising specific bioactive peptides intended to promote muscle health and recovery. This ingredient is used primarily to enhance muscle strength, endurance, and recovery, in addition to supporting bone health. It is recognized as Generally Recognized as Safe (GRAS) and is approved by Health Canada for use in dietary supplements and food products. Research on PeptiStrong® has been growing, with several randomized controlled trials demonstrating its effectiveness, although comprehensive systematic reviews are still lacking. The evidence showcases favorable results in muscle recovery and strength enhancement, particularly for populations including both males and females aged 19-40, and has potential implications for peri and post-menopausal women, specifically regarding bone density.

Benefits

PeptiStrong® shows several evidence-based benefits including: a 19.7% increase in strength over placebo in a trial over 56 days, improvements in muscular endurance, and a 1% increase in bone density. Other trials indicated that PeptiStrong® aids in strength recovery and reduces muscle fatigue after intense resistance training. Additionally, PeptiStrong® positively modulates myokine activity by increasing irisin and interleukin-15, which support muscle regeneration, while suppressing myostatin that inhibits muscle growth. The ingredient is particularly beneficial for both male and female populations and could be advantageous for peri and post-menopausal women due to its bone density effects. The strength gains observed reflect a significant clinical impact.

How it works

PeptiStrong® functions primarily through bioactive signaling peptides that influence gene expression and activate cellular signaling pathways, enhancing muscle protein synthesis and reducing fatigue. It interacts with muscular and skeletal systems to boost recovery and strength. The mechanism involves modulation of key myokines such as irisin, interleukin-15, and myostatin, thereby fostering muscle regeneration and improved exercise performance.

Side effects

The current data on the side effects of PeptiStrong® indicate that it is generally safe for use; however, detailed long-term safety profiles are limited. Common side effects occurring in more than 5% of users remain unspecified, and no uncommon or rare side effects have been identified according to the studies reviewed. There are no significant drug interactions reported, nor any known contraindications, although caution is advised for individuals with sensitivities to fava bean products. Special considerations may be warranted for peri and post-menopausal women until further long-term safety and efficacy research is conducted.

Dosage

Clinical trials suggest a minimum effective dose of 2.4g per day for PeptiStrong®. Although the optimal dosage range is not conclusively established, this dose has demonstrated significant benefits related to muscle strength and endurance improvements. Studies did not indicate adverse effects at this dosage, and the specific timing of intake does not appear critical, making daily administration recommended. There is no defined maximum safe dose available, and additional considerations for bioavailability and absorption were not detailed in the studies.