Perilla Seed Oligopeptide
Also known as: Perilla seed oligopeptides, Perilla peptides, Perilla frutescens peptides, Perilla frutescens oligopeptides
Overview
Perilla seed oligopeptides are derived from *Perilla frutescens*, a plant widely used in Asian cuisine. These peptides are extracted from the seeds and are being investigated for their potential health benefits. Research suggests they possess antioxidant, anti-inflammatory, and potential muscle growth-promoting properties. The peptides are rich in essential amino acids and bioactive compounds. While research is still emerging, current studies, including in vitro and animal models, indicate therapeutic potential. These peptides are being explored for applications ranging from enhancing skin health and reducing oxidative stress to supporting cardiovascular function and inhibiting cancer cell lines. However, more human trials are needed to confirm these findings and establish their efficacy and safety in humans. Perilla seed oligopeptides represent a promising area of research in natural health supplements.
Benefits
Perilla seed oligopeptides exhibit several potential health benefits, primarily supported by in vitro and animal studies. They demonstrate antioxidant properties, which may contribute to enhanced skin health and reduced oxidative stress. Animal studies suggest that hydrolyzed peptides from purple perilla can promote muscle growth and improve exercise tolerance by upregulating myogenic differentiation factors. Additionally, in vitro studies indicate anticancer potential through the inhibition of key cancer cell lines and cardioprotective effects via ACE-inhibitory activities. These benefits are particularly relevant for athletes seeking improved exercise performance and individuals looking to support cardiovascular health. However, the effect sizes and clinical significance in humans require further investigation through well-designed clinical trials.
How it works
Perilla seed oligopeptides exert their effects through several biological pathways. Their antioxidant activity is attributed to free radical scavenging and metal chelating activities. In terms of muscle growth, they upregulate myogenic differentiation factors such as MyoD and MyoG. These peptides interact with the musculoskeletal system by enhancing muscle synthesis and exercise performance. Furthermore, they may influence the cardiovascular system through potential ACE inhibition, which could help regulate blood pressure. The activation of the Nrf2 pathway for antioxidant defense is also a key mechanism. However, the absorption and bioavailability of these peptides are not yet fully understood, necessitating further research to elucidate their precise mechanisms of action and optimize their utilization.
Side effects
The overall safety assessment of perilla seed oligopeptides suggests they are generally safe, but this conclusion is based on limited data, particularly from human trials. Common side effects are not well-documented due to the lack of extensive human studies. Similarly, uncommon and rare side effects remain largely unknown. There is a potential for interaction with antihypertensive drugs due to the ACE inhibition properties of these peptides, although this is speculative and requires further investigation. Individuals with known allergies to *Perilla frutescens* should exercise caution. Pregnant or breastfeeding women should consult with healthcare providers before use, given the limited data available for these populations. Comprehensive human trials are necessary to fully characterize the safety profile of perilla seed oligopeptides.
Dosage
Due to the limited research on perilla seed oligopeptides, specific dosing guidelines have not been firmly established. The minimum effective dose, optimal dosage ranges, and maximum safe dose are currently unknown and require further investigation. Timing considerations for administration are also not specified and may depend on individual health goals. Peptide supplements can vary in bioavailability, necessitating more research to determine form-specific recommendations. Absorption factors and required cofactors are also not yet identified. Given the lack of comprehensive data, it is advisable to consult with a healthcare provider before using perilla seed oligopeptides to determine an appropriate and safe dosage.
FAQs
When and how should I take perilla seed oligopeptides?
There are no specific guidelines on when and how to take perilla seed oligopeptides. It is best to consult with a healthcare provider for personalized advice.
What results can I expect from taking perilla seed oligopeptides?
Expected results can vary depending on individual health goals. More research is needed to fully understand the potential benefits in humans.
Are perilla seed oligopeptides safe?
Perilla seed oligopeptides are generally considered safe, but comprehensive human trials are lacking. Consult with a healthcare provider before use.
Is there strong evidence supporting the benefits of perilla seed oligopeptides?
Most studies are in vitro or animal-based. More rigorous human studies are needed to confirm the benefits.
Research Sources
- https://onlinelibrary.wiley.com/doi/abs/10.1155/2018/1782734 – This in vitro study identified cytotoxic oligopeptides with potential anticancer applications. The research highlights the potential of these peptides in inhibiting cancer cell growth, but it is important to note that these findings are based on laboratory experiments and have not yet been validated in human trials. Further research is needed to determine the efficacy and safety of these oligopeptides in treating cancer in humans.
- https://pubmed.ncbi.nlm.nih.gov/39796337/ – This review highlights the antioxidant, anti-aging, and cardioprotective effects of perilla peptides. The review synthesizes findings from various studies, indicating potential benefits for skin health, cardiovascular function, and overall well-being. However, the authors also note the limited availability of human data, emphasizing the need for more clinical trials to confirm these effects in humans.
- https://www.mdpi.com/1420-3049/27/11/3578 – This study focuses on the antioxidant and anti-aging properties of perilla peptides, suggesting they can enhance skin health and reduce oxidative stress. The research explores the mechanisms through which these peptides combat free radicals and protect cells from damage. While the findings are promising, further studies are required to fully understand the extent of these benefits and their applicability to human health.
- https://onlinelibrary.wiley.com/doi/10.1111/jfbc.13461 – This animal study demonstrated increased muscle growth and exercise tolerance in mice treated with hydrolyzed peptides from purple perilla. The study suggests that these peptides upregulate myogenic differentiation factors, promoting muscle synthesis and improving physical performance. However, it is important to acknowledge that these results are from an animal model and require confirmation through human trials to determine their relevance to human physiology.
- https://biomedpharmajournal.org/vol12no2/a-review-on-nutritional-value-functional-properties-and-pharmacological-application-of-perilla-perilla-frutescens-l/ – This review provides a comprehensive overview of the nutritional value, functional properties, and pharmacological applications of Perilla frutescens. It covers various aspects, including its traditional uses, chemical composition, and potential health benefits. The review highlights the plant's diverse applications and underscores the need for further research to fully unlock its therapeutic potential.
Supplements Containing Perilla Seed Oligopeptide
GLP-X SUPER EVOLUTION
Fmlave
GLP-1 3X Targeted Formula
Todesessis
GLP-1 Supplement for Women & Men, GLP1 Supplements with Akkermansia Probiotic, Berberine, Natural GLP-1 Support - GLP1 for Immune, GLP-1 Levels, Digestion, Gut & Overall Health, Vegan
VINNETLLOY