Peucedanum Praeruptorum Root Extract
Also known as: Qianhu, yimacai, luoguicai, shuiqianhu, shuifangfeng, shanyuansui, guanqianhu, shanduhuo, Peucedanum praeruptorum
Overview
Peucedanum praeruptorum Dunn is a plant species traditionally used in Chinese medicine, particularly known for its roots, which are employed to treat a variety of health issues, especially those related to respiratory ailments such as cough and asthma. Recent studies have begun to explore its potential anticancer and anti-inflammatory properties. The plant contains an array of phytochemicals including coumarins, flavonoids, and sterols, which contribute to its therapeutic effects. Despite its established role in traditional remedies, modern research into its pharmacological effects is still emerging, and most available data originates from in vitro and animal studies rather than robust human clinical trials.
Benefits
Research suggests several potential benefits of Peucedanum praeruptorum, including its anticancer effects, particularly in non-small-cell lung cancer cells, as well as anti-inflammatory properties and protective effects against gastric injury. Specific populations, such as patients with EGFR mutation-related cancers, may find these benefits particularly relevant. However, the efficacy and clinical significance of these benefits remain underexplored and not well quantified in the existing literature, highlighting an urgent need for more comprehensive human studies to understand its true impact and therapeutic potential.
How it works
The anticancer properties of Peucedanum praeruptorum are primarily attributed to its ability to suppress MET activity and interfere with the STAT3/AKT signaling pathways involved in cell growth and apoptosis in cancer cells. Additionally, it may modulate inflammatory responses, indicating a multifaceted mechanism of action that engages various biological pathways and systems within the body.
Side effects
Currently, the safety profile of Peucedanum praeruptorum is generally considered acceptable based on traditional uses, though modern data is limited. Common side effects are not well documented, and specific adverse effects remain largely unknown. There is some speculation regarding potential interactions with cancer therapies or other medications, but no established drug interactions or contraindications. As such, caution is warranted, especially in pregnant or lactating women and children, due to the absence of extensive safety data regarding these populations.
Dosage
Dosage guidelines for Peucedanum praeruptorum have not been adequately established due to limited clinical research. There are no defined minimum effective or maximum safe doses, nor are timing considerations clearly specified. Traditionally, it is used as a root extract, but variability in forms and preparation methods may affect absorption and efficacy. Without sufficient human studies, recommendations regarding dosing should remain conservative and should ideally involve consultation with a healthcare professional.
FAQs
Is Peucedanum praeruptorum effective for cancer treatment?
While some studies suggest anticancer properties, more human clinical trials are needed to establish its efficacy as a cancer treatment.
Are there any known side effects?
Documented side effects are minimal, but due to limited safety data, caution is advised, particularly for pregnant or lactating individuals.
What is the recommended dosage?
No established dosage guidelines exist; consulting with a healthcare provider is recommended for appropriate use.
Can it interact with other medications?
Potential interactions with medications exist but are speculative; always consult with a healthcare provider before use.
Is it safe to use in children?
Safety data in pediatric populations is lacking, so it's crucial to seek professional advice prior to use.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/35408753/ – This study provides evidence of the anticancer effects of Peucedanum praeruptorum in human non-small-cell lung cancer cell lines through MET activity suppression and apoptosis induction, emphasizing the need for further clinical validation due to its in vitro nature.
- https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1352657/full – An animal study demonstrating the protective effect of Peucedanum praeruptorum against alcoholic gastric injury, attributed to reduced inflammation and oxidative stress; this study underscores the potential anti-inflammatory effects necessitating human trials for confirmation.
- https://www.frontiersin.org/journals/plant-science/articles/10.3389/fpls.2022.1011001/full – This review explores the phytochemistry and pharmacological activities of Peucedanum praeruptorum, highlighting its anticancer, anti-inflammatory, and neuroprotective properties while calling for further research to solidify these claims.