axivite
Also known as: aXivite, phenylcapsaicin, Phenylcapsaicin
Overview
Phenylcapsaicin, marketed as aXivite, is a synthetic analogue of capsaicin, the active compound found in chili peppers. It is designed to mimic the thermogenic and metabolic effects of natural capsaicin but with potentially improved efficacy and tolerability. aXivite is primarily studied and marketed as a nutritional supplement for weight management, body composition improvement, and gut health. Early research also suggests its potential in sports nutrition for enhancing athletic performance. It is classified as a thermogenic and metabolic modulator, influencing energy expenditure and fat oxidation. While promising, the research on aXivite is still in its early stages, with a limited number of randomized controlled trials available.
Benefits
aXivite has demonstrated several evidence-based benefits. A randomized, double-blind, placebo-controlled clinical trial showed statistically significant reductions in body fat, improved body shape, and increased lean mass after 8 weeks of supplementation with 0.56 mg/day. The same trial also reported improved gut health, indicated by a decrease in serum zonulin, a marker of intestinal permeability. These effects were observed in overweight, recreationally active adults. Additionally, a 2023 study found that 2.5 mg of aXivite significantly improved mean velocity and reduced velocity loss during squats in trained men, suggesting enhanced muscular performance. While the clinical trial reported statistically significant changes, exact effect sizes were not detailed. The benefits were observed over an 8-week supplementation period, primarily in healthy, active adult populations.
How it works
Phenylcapsaicin, or aXivite, functions primarily as an agonist of the transient receptor potential vanilloid 1 (TRPV1) receptor. This mechanism is similar to that of natural capsaicin. By activating TRPV1, aXivite modulates thermogenesis, leading to increased energy expenditure and fat oxidation. It also influences metabolic rate and may improve gut barrier integrity, as suggested by the reduction in serum zonulin levels. While specific pharmacokinetic data for aXivite are limited, its design as a capsaicin analogue suggests improved tolerability and potentially better bioavailability compared to natural capsaicin.
Side effects
The available clinical research on aXivite indicates an excellent safety and tolerability profile at tested doses. An 8-week clinical trial reported no significant adverse effects at doses of 0.56 mg/day and 1.12 mg/day. There are no reported common, uncommon, or rare side effects associated with aXivite in the current literature. However, data on drug interactions are not available, so caution is advised, especially given its involvement with the TRPV1 receptor. Contraindications have not been established, but standard precautions for supplements affecting metabolism and gut function should be considered. Safety in special populations such as pregnant or lactating individuals, or those with pre-existing medical conditions, is unknown as research has been limited to healthy adults.
Dosage
Based on current clinical evidence, the minimum effective dose of aXivite appears to be 0.56 mg/day, which showed significant effects in body composition and gut health. Optimal dosage ranges are between 0.56 mg/day and 1.12 mg/day for these benefits. Higher doses, such as 2.5 mg, have been used in studies focusing on exercise performance. The maximum safe dose has not been definitively established, but doses up to 2.5 mg have been used in trials without reported safety issues. Supplementation is typically taken daily, though specific timing relative to meals or exercise is not detailed. It is generally administered as an oral supplement in capsule or tablet form. No specific cofactors are reported as required for its efficacy.
FAQs
Is aXivite safe for long-term use?
Current data from an 8-week clinical trial indicate good safety and tolerability. However, longer-term studies are needed to fully assess its safety profile for extended use.
How soon can benefits be expected?
Improvements in body composition and gut health were observed after 8 weeks of consistent supplementation in clinical trials.
Does aXivite cause the burning sensation typical of capsaicin?
As a synthetic analogue, aXivite is designed to have potentially improved tolerability. While specific sensory effects were not detailed, it may have reduced pungency compared to natural capsaicin.
Can aXivite enhance athletic performance?
Preliminary evidence suggests that aXivite can improve muscular velocity and reduce velocity loss during resistance exercise, indicating potential for enhanced athletic performance.
Is aXivite effective without diet and exercise?
The clinical trial demonstrating benefits combined aXivite supplementation with calorie restriction and increased physical activity, so its isolated effects without these lifestyle changes are unclear.
Research Sources
- https://blog.priceplow.com/supplement-ingredients/axivite-phenylcapsaicin/muscletech – This source provides an overview of aXivite (phenylcapsaicin), detailing its classification as a synthetic capsaicin analogue and its potential uses in weight management, gut health, and sports nutrition. It highlights early clinical research and the compound's mechanism of action, emphasizing its role as a TRPV1 agonist.
- https://axivite.com/clinical-trial-weight-and-gut-health/ – This source describes a randomized, double-blind, placebo-controlled clinical trial on aXivite's effects on body composition and gut health. It reports significant reductions in body fat, improved lean mass, and decreased serum zonulin (a marker of gut permeability) after 8 weeks of supplementation, indicating positive effects on both weight management and gut barrier function.
