Phytosorb Blend
Also known as: Plant sterols, Plant stanols, Phytosterols
Overview
Phytosterols are naturally occurring compounds found in various plant sources, such as fruits, vegetables, nuts, and seeds. They have a structure similar to cholesterol and are primarily recognized for their cholesterol-lowering effects. Phytosterols work by inhibiting the absorption of dietary cholesterol in the intestines, thereby facilitating a reduction in LDL cholesterol levels in the blood. Well-researched and supported by numerous systematic reviews and meta-analyses, their usage in dietary supplements is primarily targeted at individuals with elevated cholesterol levels. The cholesterol-lowering properties are well documented, with high-quality evidence affirming their effectiveness in reducing both LDL and total cholesterol concentrations.
Benefits
Phytosterols are shown to significantly lower LDL cholesterol and total cholesterol levels. A daily intake of about 1.6 to 2.2 grams is associated with a decrease in LDL cholesterol by approximately 0.33 mmol/L and total cholesterol by 0.36 mmol/L. Although primarily beneficial for adults with elevated cholesterol levels, some preclinical studies suggest potential anti-cancer properties. The clinical significance of cholesterol reduction has been established, with effects usually observable within weeks of regular intake. Overall, the evidence supports a moderate to large effect, heavily reliant on baseline cholesterol levels and dosage.
How it works
Phytosterols reduce cholesterol absorption by competing with dietary cholesterol for incorporation into micelles in the small intestine, which diminishes the quantity of cholesterol entering the bloodstream. They significantly impact the gastrointestinal system and lipid metabolism. Their mechanism involves displacing cholesterol rather than being absorbed themselves, which is essential for their cholesterol-lowering effect.
Side effects
Phytosterols are generally recognized as safe for consumption, with few adverse effects reported. Commonly, individuals may experience mild gastrointestinal upset. There are no significant rare or unusual side effects documented. Caution is advised when combining phytosterols with cholesterol-lowering medications, and individuals with sitosterolemia - a rare genetic disorder affecting fat metabolism - should avoid phytosterols. Pregnant or breastfeeding women are also encouraged to seek medical advice before consumption.
Dosage
The minimum effective dose of phytosterols is approximately 0.8 grams per day. For significant cholesterol reduction, an optimal daily intake ranges from 1.6 to 2.2 grams. While the maximum safe dosage isn't well-defined, exceeding 3 grams per day is generally not recommended. For best results, phytosterols should be taken with meals to enhance their intestinal absorption, although their primary mechanism does not rely on absorption. They are commonly included in fortified foods, such as margarine and cereals.
FAQs
What is the best way to consume phytosterols?
Phytosterols are best consumed as part of a balanced diet, particularly through fortified foods like margarine and cereals.
Are phytosterols safe?
Phytosterols are generally considered safe, but individuals with specific health conditions should consult their healthcare provider before use.
When should I take phytosterols?
They are most effective when taken with meals, which helps improve their cholesterol absorption-inhibiting action.
How quickly will I see results from phytosterols?
You can expect noticeable cholesterol reductions within a few weeks of consistent intake.
Do phytosterols affect HDL cholesterol?
Phytosterols primarily lower LDL cholesterol and do not have a significant impact on HDL cholesterol or triglyceride levels.
Research Sources
- https://www.foodstandards.gov.au/sites/default/files/publications/Documents/EU%20health%20claims%20reviews/Systematic%20review%20phytosterols%20and%20cholesterol.pdf – This systematic review and meta-analysis of 84 trials confirmed that phytosterol consumption significantly reduces LDL cholesterol levels, with a mean decrease of 0.34 mmol/L per average intake of 1.6 grams per day.
- https://www.tandfonline.com/doi/full/10.1080/10408398.2020.1835820 – Building on previous findings, this review corroborates the consistent cholesterol-lowering effects of phytosterols, further emphasizing their role in managing cholesterol levels across various populations.
- https://pubmed.ncbi.nlm.nih.gov/37225641/ – In a recent meta-analysis spanning 125 studies, it was found that phytosterol-fortified foods effectively lowered LDL cholesterol by an average of 0.55 mmol/L, highlighting sustained benefits across subgroups.
