Pikatropin
Also known as: N-nicotinoyl-GABA, pycamilon, pikamilon, Picamilon
Overview
Picamilon is a synthetic compound formed from the combination of niacin (vitamin B3) and γ-aminobutyric acid (GABA). Developed in the Soviet Union in 1969, it is often categorized as a nootropic or cognitive enhancer due to its purported ability to enhance cerebral blood flow and interact with GABA receptors. Picamilon does not occur naturally and is synthesized for medical usage, primarily in Russia and Japan. The compound is hydrolyzed into GABA and niacin upon being absorbed, which facilitates its effects on the central nervous system. While it is believed to have cognitive benefits, the research surrounding Picamilon is limited, consisting mainly of studies with animal models and a few human trials, leading to uncertainty about its efficacy and safety. Regulatory authorities in the U.S. have not approved Picamilon, categorizing it as an adulterating agent in dietary supplements.
Benefits
Potential benefits of Picamilon include improved cerebral blood flow, which may enhance cognitive functions such as memory and learning. However, strong evidence supporting these claims is scarce, primarily drawn from limited studies. While it is theorized that Picamilon may help alleviate anxiety due to its interaction with GABA systems, these effects have not been robustly validated in human studies. The findings remain largely speculative with no quantifiable outcomes documented in human trials, emphasizing the need for further research to establish its effectiveness and define specific populations that may benefit.
How it works
Picamilon is believed to enhance cerebral blood flow, facilitating improved oxygen and nutrient delivery to the brain. After crossing the blood-brain barrier, it hydrolyzes into GABA and niacin. The GABA component may help regulate neuronal excitability and influence the central nervous system's activity. However, recent studies raise questions about its direct interaction with GABA receptors, suggesting a need for further investigation into its exact mechanisms.
Side effects
The safety profile of Picamilon is not well-documented, and available data on side effects are minimal. Reports indicate that adverse effects may occur, but specific occurrences have not been quantified. Common side effects (>5%) have not been established. Rare side effects (<1%) have also not been thoroughly investigated. Additionally, there are no widely acknowledged drug interactions or contraindications noted in existing literature. Picamilon is not approved in the U.S., and its usage should be approached with caution, particularly among special populations like pregnant or nursing women, children, or individuals with existing health conditions due to the uncertainty surrounding its safety and efficacy.
Dosage
For Picamilon, typical dosages range from 50 to 200 mg, although specific dosing guidelines are not well-established. It is usually administered orally, and timing and absorption factors have not been extensively studied. A lack of data prevents defining minimum effective doses or maximum safe limits. Healthcare professionals generally advise cautious use until more comprehensive research is available to clarify these aspects.
FAQs
Is Picamilon safe to use?
The safety of Picamilon is uncertain as it is not approved in the U.S. and lacks thorough safety studies. Caution is advised.
How does Picamilon work?
Picamilon is thought to enhance cerebral blood flow and may influence GABA activity after hydrolysis, though its precise action remains unclear.
What are the expected benefits of Picamilon?
Potential benefits include improved cognitive function and reduced anxiety, but these claims are not well-supported by robust clinical evidence.
What dosage is recommended for Picamilon?
Typical dosages range from 50 to 200 mg; however, no specific guidelines are available, so professional guidance is recommended.
Can I find Picamilon in dietary supplements?
Picamilon is classified as an adulterating agent in dietary supplements in the U.S., so its inclusion is prohibited.
Research Sources
- https://www.scielo.br/j/cta/a/MB3R73rgwDHr8PPPS9JjJSx/ – This study provides insights into the cognitive effects of Picamilon, noting that its usage is primarily supported by limited Russian and Japanese research.
- https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2023.1093988/full – The paper reviews the pharmacokinetics of Picamilon, highlighting its hydrolysis into GABA and niacin along with the ongoing debate regarding its interaction with GABA receptors.
- https://pubmed.ncbi.nlm.nih.gov/22212388/ – This study discusses the safety and efficacy profile of Picamilon alongside a review of pharmacological studies focusing on its potential uses.
- https://en.wikipedia.org/wiki/Picamilon – The Wikipedia page provides a comprehensive overview of Picamilon, including its history, properties, potential benefits, and existing regulatory issues surrounding its usage.
- https://pubmed.ncbi.nlm.nih.gov/29508691/ – This research article examines existing literature on Picamilon, underlining the necessity for more extensive human trials to verify its proposed effects.
Supplements Containing Pikatropin
Mr Hyde Pre Workout Amplifier Orange Guava
PS ProSupps
Mr Hyde Pre Workout Amplifier Grape
PS ProSupps
Mr Hyde Pre Workout Amplifier Blue Razz
PS ProSupps
Dr. Jekyll Orange Guava
PS ProSupps
Vanish
PS ProSupps
ENGN Pre-Workout Engine Fruit Punch
Evlution Nutrition