ProveIt Supplements

Independent, evidence-based supplement analysis.

✓ Not Sponsored

✓ No Paid Reviews

✓ Science-Based

Company

  • About Us
  • Our Methodology
  • Contact
  • Blog
  • Authors

Legal

  • Privacy Policy
  • Terms of Service
  • Medical Disclaimer
  • Affiliate Disclosure

Resources

  • All Categories
  • Ingredient Database
  • Browse Supplements
  • FAQ

© 2025 ProveIt Supplements. All rights reserved.

Medical Disclaimer: The information provided is for educational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen.

Prove It
Browse SupplementsBlogAuthorsAboutMethodologyFAQ
Get Your Personalized Supplement StackSupplement Stack Quiz
Menu
HomeBrowse SupplementsBlogAuthorsAboutMethodologyFAQ
Back

Pipsissewa

Also known as: Chimaphila umbellata, Chimaphila maculata, Pipsissewa, Prince's Pine, Wintergreen

Overview

Pipsissewa, scientifically known as *Chimaphila umbellata*, is a perennial evergreen plant native to North America. It has a history of traditional medicinal use, primarily for its purported antiseptic and astringent properties. Historically, it has been used to address urinary tract infections (UTIs), bladder issues, and skin sores. The plant contains various compounds, including flavonoids, phenolic acids, and terpenoids, which are believed to contribute to its potential therapeutic effects. However, it's important to note that the scientific evidence supporting these traditional uses is currently limited. Pipsissewa is typically consumed as a tea or extract. Due to the limited research, caution is advised when considering its use as a supplement.

Benefits

Currently, there is insufficient scientific evidence to definitively support the effectiveness of pipsissewa for any specific health condition. Traditional uses include treatment for urinary tract infections (UTIs) and bladder issues, but these claims lack robust scientific validation. No well-documented secondary effects or population-specific benefits have been established through rigorous research. Effect sizes and clinical significance are not quantifiable due to the absence of comprehensive studies. Therefore, any perceived benefits are largely based on anecdotal evidence and traditional use rather than conclusive scientific findings. More research is needed to determine if pipsissewa offers any tangible health benefits.

How it works

The exact mechanism of action of pipsissewa is not well-understood. It is suggested that potential antimicrobial and astringent effects may play a role in its traditional uses, but these have not been thoroughly investigated. The interaction of pipsissewa with human physiology and specific molecular targets remains largely unknown. The absorption and bioavailability of its active compounds are also not well-characterized. Further research is needed to elucidate the biological pathways and mechanisms through which pipsissewa might exert any potential effects.

Side effects

The overall safety profile of pipsissewa is not comprehensively established due to limited scientific data. While it is generally considered safe when used as directed, there is a lack of well-documented common, uncommon, or rare side effects. Potential drug interactions with other medications are also not well-studied. Due to the lack of evidence, no specific contraindications have been established, but caution is advised. Pregnant or breastfeeding women should consult healthcare providers before use, as there is insufficient safety data for these populations. It is important to be aware of the limited safety information available and to exercise caution when considering pipsissewa as a supplement.

Dosage

Due to the lack of scientific research, there is no established minimum effective dose, optimal dosage range, or maximum safe dose for pipsissewa. Timing considerations for its use are also unknown. It is typically used as a tea or extract, but form-specific recommendations are not available. Absorption factors and required cofactors have not been identified. Given the limited data, it is crucial to exercise caution and consult with a healthcare provider before using pipsissewa to determine appropriate and safe usage guidelines.

FAQs

Is pipsissewa effective for treating UTIs?

There is currently insufficient scientific evidence to support the effectiveness of pipsissewa for treating UTIs. Traditional use suggests potential benefits, but these claims lack robust scientific validation.

Is pipsissewa safe to use during pregnancy or breastfeeding?

Pregnant or breastfeeding women should consult with a healthcare provider before using pipsissewa due to insufficient safety data for these populations. Caution is advised.

How should I take pipsissewa?

Due to the lack of scientific research, there are no specific guidelines on how to take pipsissewa. It is typically used as a tea or extract, but consult with a healthcare provider for personalized advice.

Are there any known side effects of pipsissewa?

The side effects of pipsissewa are not well-documented due to limited scientific data. Exercise caution and discontinue use if any adverse reactions occur. Consult a healthcare provider if needed.

Research Sources

  • https://pmc.ncbi.nlm.nih.gov/articles/PMC10136598/ – This article reviews herbal medicines for treating benign prostatic hyperplasia (BPH). It discusses various herbal remedies and their potential mechanisms, but does not provide specific evidence for pipsissewa's efficacy or safety. The review highlights the need for more rigorous clinical trials to validate the effectiveness of herbal treatments for BPH.
  • https://www.sciencedirect.com/science/article/abs/pii/S1071909111000544 – This article discusses the use of botanicals in urology. It provides an overview of various plant-based treatments for urological conditions, but does not offer specific details or evidence related to pipsissewa. The article emphasizes the importance of understanding the pharmacological properties and clinical efficacy of botanicals used in urological care.
  • https://www.webmd.com/vitamins/ai/ingredientmono-102/pipsissewa – WebMD states that there is insufficient scientific evidence to support any of the purported uses of pipsissewa. This suggests that the traditional uses of pipsissewa lack strong scientific backing and further research is needed to determine its potential benefits and risks.
  • https://pmc.ncbi.nlm.nih.gov/articles/PMC8713254/ – This review focuses on herbal treatments for urinary tract infections (UTIs). While it discusses various herbal remedies, it does not provide specific evidence for the efficacy of pipsissewa in treating UTIs. The review emphasizes the need for well-designed clinical trials to assess the effectiveness of herbal interventions for UTIs.
  • https://www.sciencedirect.com/topics/medicine-and-dentistry/goshajinkigan – This ScienceDirect page provides information on Goshajinkigan, a traditional Japanese medicine. It is not directly related to pipsissewa, and therefore does not provide any information on its efficacy or safety. The page focuses on the uses and components of Goshajinkigan in treating various conditions.

Supplements Containing Pipsissewa

Prostate Health by Herb Pharm
83

Prostate Health

Herb Pharm

Score: 83/100
Prostate Health by Herb Pharm
85

Prostate Health

Herb Pharm

Score: 85/100
Kidney Tonic by Herbs Etc.
45

Kidney Tonic

Herbs Etc.

Score: 45/100