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Pituitary Gland Abgland Bovine

Also known as: Pituitary Gland Abgland Bovine, Bovine Pituitary Extract, BPE

Overview

Bovine Pituitary Extract (BPE) is derived from the pituitary glands of young, healthy bovines. It is a complex mixture of hormones, growth factors, and proteins that supports cell growth and differentiation, making it predominantly used in cell culture media. BPE is highly concentrated and available in both filtered and unfiltered forms. While research concerning its efficacy and safety is mature in the context of in vitro applications, concerns about its use in humans are extensive due to the absence of comprehensive clinical trials. Current literature primarily highlights its role in enhancing the proliferation of epithelial cells and stem cells, but the benefits for human supplementation remain largely unclear.

Benefits

BPE significantly promotes cell growth in vitro, particularly for epithelial and stem cells, enhancing tissue repair and regeneration in laboratory settings. However, quantifiable outcomes specific to human applications are poorly documented, and there is no established clinical significance due to the lack of studies involving human subjects. The strength of evidence primarily supports its in vitro efficacy, emphasizing its utility in laboratory environments rather than clinical use.

How it works

BPE acts primarily via growth factors and hormones to stimulate cell proliferation and differentiation in cell culture. It enhances cellular pathways, particularly through interaction with receptors for insulin-like growth factor (IGF-1) and various hormones. While its mechanism is well-documented in vitro, its effects in humans remain speculative and unsupported by clinical data.

Side effects

The overall safety profile of BPE is generally considered acceptable in cell culture environments; however, its safety for human use is not well-established due to a lack of data. Common side effects in humans are unknown, and there is limited information on rare or uncommon adverse effects. Potential risks such as Bovine Spongiform Encephalopathy (BSE) associated with bovine-derived products are present, though modern production methods have mitigated these risks. Documented drug interactions and contraindications remain sparse, and special population considerations are still unclear.

Dosage

No established dosage guidelines are available for human use of BPE, as it is primarily utilized in laboratory settings. There are no minimum effective or optimal dosage ranges defined, nor any maximum safe doses documented. Timing considerations and form-specific recommendations do not apply for human supplementation due to the lack of relevant data. Absorption factors and required cofactors are also unknown.

FAQs

Can BPE be used as a human supplement?

BPE is not typically used as a human supplement; its primary application is in cell culture.

Is BPE safe for human consumption?

Safety in humans is not well-studied, and thus, caution is recommended.

What results can be expected from BPE?

Expected results for human supplementation are not established due to the absence of clinical studies.

Is BPE the same as bovine somatotropin?

BPE is often confused with bovine somatotropin (bST), but they are different products.

Research Sources

https://www.cellapplications.com/bpe-bovine-pituitary-extract – This source outlines the applications of Bovine Pituitary Extract in cell culture, describing its composition and effects primarily in vitro.
https://www.fda.gov/animal-veterinary/product-safety-information/bovine-somatotropin-bst – This FDA resource discusses bovine somatotropin, providing insights into regulatory considerations and the use of bovine-derived products.
https://food.ec.europa.eu/document/download/14f3d449-0ff2-4f7e-8d7f-98bc56f4444b_en?filename=sci-com_scv_out19_en.pdf&prefLang=et – This document from the European Food Safety Authority addresses safety evaluations related to bovine-derived products, including implications for human health.
https://pubmed.ncbi.nlm.nih.gov/14690452/ – A PubMed entry that looks into the biological impact of hormones found in BPE; however, it lacks specific focus on human applications.
https://pubmed.ncbi.nlm.nih.gov/291899/ – Another PubMed study that explores the physiological effects of bovine-derived hormones in laboratory settings without human trials.