Porcine Brain Pmg Extract
Also known as: Porcine Brain PMG Extract, Porcine brain extract, Porcine brain hydrolysate, Porcine brain PMG™ extract
Overview
Porcine Brain PMG (Protomorphogen™) Extract is a supplement derived from pig brain tissue, containing a mixture of nucleotides, peptides, and amino acids. It is marketed to support brain function, memory, and neuroprotection. The extract is processed to concentrate specific compounds believed to have neurotrophic effects. While some commercial products standardize the extract as a proprietary blend, research on Porcine Brain PMG Extract is still in its early stages, with most evidence coming from preclinical studies. These studies have explored its potential in enhancing memory and cognitive function, as well as its role in osteogenic differentiation. However, the limited human clinical trials and lack of systematic reviews necessitate cautious interpretation of its benefits and safety.
Benefits
Preclinical studies suggest potential benefits, primarily in animal models. Porcine brain enzyme hydrolysate (PBEH) has shown improvements in neurological scores, motor performance, and reduced hippocampal acetylcholinesterase activity, indicating potential for memory enhancement. Additionally, in vitro and animal studies suggest that porcine brain extract (PBE) may enhance osteogenic differentiation and bone consolidation, although this is not directly related to brain health. PBEH has also been shown to modulate gut microbiota in animal models, increasing α-diversity and influencing energy metabolism-related pathways. However, the clinical significance of these findings in humans remains uncertain due to the lack of robust human data.
How it works
Porcine Brain PMG Extract is believed to exert its effects through multiple biological pathways. It may offer neuroprotection by reducing acetylcholinesterase activity, improving brain insulin resistance, and reducing neuroinflammation. The extract can also modulate the gut microbiota, influencing associated metabolic pathways and potentially affecting the gut-brain axis. Furthermore, it has been shown to enhance osteogenic differentiation in mesenchymal stem cells. The precise mechanisms of absorption and bioavailability in humans are not well-characterized, but animal studies suggest that peptides and amino acids are orally bioavailable.
Side effects
Due to limited human safety data, the side effect profile of Porcine Brain PMG Extract is not well-established. Preclinical studies have not reported significant adverse effects at tested doses. However, caution is advised, particularly for individuals with pork allergies or religious/cultural restrictions. There are no known drug interactions reported. The extract has not been studied in pregnant or lactating women, children, or immunocompromised individuals, so its use in these populations is not recommended without further research. More comprehensive human studies are needed to fully assess the safety and tolerability of Porcine Brain PMG Extract.
Dosage
Optimal dosage ranges for Porcine Brain PMG Extract in humans have not been established due to limited clinical trials. Animal models have used human-equivalent doses of 1.5–4.5 mL of 7 mg total nitrogen/mL PBEH. Commercial products typically suggest a dosage of 1 tablet (containing 145–200 mg porcine brain PMG extract) three times daily. Some manufacturers recommend taking the supplement on an empty stomach. The maximum safe dose has not been determined. Bioavailability may vary depending on the specific formulation (tablets or liquid extracts) and the peptide and amino acid composition of the extract.
FAQs
Is Porcine Brain PMG Extract safe?
Preclinical studies suggest no significant adverse effects at tested doses, but human safety data is limited. Caution is advised, especially for those with pork allergies. Consult a healthcare provider before use.
How should I take Porcine Brain PMG Extract?
Commercial products often recommend taking it three times daily on an empty stomach. However, consult the specific product label and a healthcare provider for personalized advice.
What are the expected benefits of Porcine Brain PMG Extract?
Preclinical data suggest potential memory and cognitive benefits, but human outcomes are speculative. More research is needed to confirm these effects in humans.
Can Porcine Brain PMG Extract regenerate brain cells?
Claims of 'brain regeneration' or 'neurogenesis' are not supported by current evidence. The supplement may support brain function, but it is not proven to regenerate brain cells.
Research Sources
- https://pmc.ncbi.nlm.nih.gov/articles/PMC8951530/ – This animal study investigated the long-term effects of porcine brain enzyme hydrolysate (PBEH) on memory and gut microbiota in rats. The study found that PBEH improved memory, reduced acetylcholinesterase activity, and modulated gut microbiota composition, suggesting a potential link between gut health and cognitive function. The results indicate that PBEH could be a promising supplement for enhancing memory and cognitive function.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC5665543/ – This study examined the effects of porcine brain extract (PBE) on osteogenic differentiation of bone marrow-derived mesenchymal stem cells. The findings showed that PBE enhanced osteogenic differentiation and bone consolidation in rats. While the study provides mechanistic insights into bone metabolism, its relevance to the primary marketed use of porcine brain extract for brain health is limited.
- https://www.danielsfamilychiro.com/storage/app/media/Patient_Information-_Supplementation/Neurotrophin_PMG.pdf – This document provides patient information on Neurotrophin PMG, highlighting its use in supporting nervous system function. It describes the product as containing Protomorphogen extracts, which are designed to provide cellular support. The information is primarily marketing material and lacks detailed scientific evidence.
- https://www.standardprocess.com/products/neurotrophin-pmg – This is a product page for Neurotrophin PMG by Standard Process, describing it as a supplement to support neurological health. The page lists ingredients and suggested use, but it does not provide independent scientific evidence of efficacy. The information is promotional and should be viewed as such.
- https://nutripetpak.com/products/standardprocess-neurotrophin-pmg-5900 – This is another product page for Standard Process Neurotrophin PMG, marketed for both human and animal use. It reiterates the claims of supporting neurological function but lacks independent scientific validation. The information is primarily for marketing purposes and should be interpreted with caution.
