Porcine Liver Aqueous Extract
Also known as: Porcine liver extract, Pig liver extract, Aqueous liver extract, Porcine Liver Aqueous Extract
Overview
Porcine liver aqueous extract is a water-based extract derived from the liver tissue of pigs (Sus scrofa domesticus). It is rich in proteins, peptides, vitamins (notably B vitamins), minerals (iron, zinc), and bioactive compounds such as growth factors and enzymes. Traditionally, it has been used in organotherapy to support liver function, improve hematologic parameters, and enhance general vitality. It is sometimes marketed for liver health, anemia, and nutritional supplementation. The extract contains a complex mixture of amino acids, peptides, vitamins, and minerals. Bioactive peptides may have regenerative or immunomodulatory properties. However, direct clinical research on the extract itself is limited, with most studies focusing on liver regeneration models or the nutritional effects of liver-derived components. High-quality randomized controlled trials (RCTs) on porcine liver aqueous extract as a supplement are sparse, with more evidence existing in animal models or surgical liver regeneration contexts.
Benefits
While porcine liver extracts may provide nutritional support via iron and B vitamins, potentially aiding anemia and general metabolic health, clinical evidence is indirect. Based on animal studies, it may be potentially beneficial for patients with liver injury or post-surgical liver regeneration. However, there is a lack of direct RCTs meeting strict criteria on porcine liver aqueous extract supplementation in humans. Research on liver regeneration in pigs suggests potential bioactivity in promoting liver tissue repair and function. Effect sizes and clinical significance are not established due to the lack of direct human RCTs. Liver regeneration studies in pigs show effects over days to weeks post-injury.
How it works
Porcine liver aqueous extract contains growth factors and peptides that may stimulate hepatocyte proliferation and liver regeneration pathways. It also provides essential nutrients (iron, B vitamins) critical for hematopoiesis and metabolic enzyme function. It primarily affects hepatic tissue and hematologic systems and may influence immune modulation via bioactive peptides. Known molecular targets include hepatocyte growth factor (HGF) pathways, cellular proliferation signaling, and nutrient-dependent enzymatic pathways. Water-soluble components are likely absorbed in the gastrointestinal tract, with bioavailability depending on preparation and digestion.
Side effects
Porcine liver aqueous extract is generally considered safe when derived from properly processed porcine liver. However, there is a risk of contamination or allergenicity if improperly handled. No well-documented side effects have been reported from clinical trials. Possible mild gastrointestinal discomfort is uncommon. Rare side effects include allergic reactions in sensitive individuals. No documented drug interactions exist, but caution is advised with anticoagulants due to the vitamin K content in the liver. It should be avoided in individuals with pork allergies or religious dietary restrictions. Limited data are available for pregnant or immunocompromised populations.
Dosage
The minimum effective dose of porcine liver aqueous extract is not established due to a lack of clinical trials. Optimal dosage ranges are not defined. The maximum safe dose is also not established, and caution is advised to avoid excessive vitamin A or iron intake. There is no data on timing considerations. It is typically administered as aqueous extracts or capsules. Absorption may be enhanced by concurrent intake of vitamin C for iron absorption. No required cofactors have been specifically identified.
FAQs
Is porcine liver aqueous extract effective for liver health?
Evidence is indirect and primarily from animal models. No high-quality human RCTs confirm efficacy.
Is it safe to consume?
Generally safe if properly processed, but allergy and contamination risks exist.
How long before effects are noticed?
Unknown; liver regeneration in animal models occurs over days to weeks.
Can it replace conventional liver treatments?
No; it should not replace medical treatments.
Research Sources
- https://www.mdpi.com/2073-4409/12/4/603 – This review of experimental surgical models using pigs demonstrated liver regeneration mechanisms and the potential for porcine liver extracts to support regeneration. While the study provides mechanistic insight, it is important to note that it is based on animal models and not human clinical trials. Therefore, the findings are relevant for understanding potential mechanisms but do not directly translate to clinical efficacy in humans.
- https://www.mdpi.com/2077-0383/12/1/235 – This systematic review and meta-analysis focused on liver transplant patients and found improved graft survival with normothermic perfusion techniques. While the study is high quality, its relevance to porcine liver extract supplementation is indirect. The findings primarily highlight factors influencing liver tissue viability in the context of transplantation rather than the effects of supplementation.