Porcine Mesenchyme Aqueous Extract 125x
Also known as: Porcine Mesenchyme Aqueous Extract 125x, Porcine mesenchymal stem cell extract, Porcine mesenchymal stromal cell extract, Porcine Mesenchyme Aqueous Extract
Overview
Porcine mesenchyme aqueous extract is a concentrated extract derived from the mesenchymal tissue of pigs, primarily bone marrow-derived mesenchymal stem cells (MSCs) or their extracellular vesicles (EVs). These multipotent stromal cells can differentiate into various cell types, making the extract of interest for regenerative medicine applications. It contains bioactive components such as cytokines, growth factors, and extracellular vesicles, which may mediate tissue repair and immunomodulation. Research is primarily preclinical, using animal models to investigate potential benefits in conditions like ischemic injury, lung injury, and fibrosis. Human clinical data are limited, and the extract's efficacy and safety as a supplement are not yet established. The extract is typically administered via injection in research settings, and its bioavailability via other routes is not well-studied. Further rigorous clinical research is needed to confirm its potential benefits and safety in humans.
Benefits
Evidence suggests potential benefits in animal models of ischemic heart disease and lung injury. Meta-analyses indicate that stem cell therapy, including porcine MSCs, can improve heart function in large animal models of ischemic injury. Studies also show a reduction in lung injury and fibrosis in animal models treated with MSCs, including improved survival rates in paraquat poisoning models. Furthermore, the extract has shown the potential to form ectopic bone and hematopoietic microenvironments when implanted, indicating differentiation and regenerative potential. However, these benefits are primarily observed in preclinical studies, and the exact effect sizes for the extract form are not detailed. Clinical significance in humans remains uncertain due to the lack of human trials.
How it works
Porcine mesenchyme aqueous extract is believed to exert its effects through paracrine signaling. The MSCs within the extract release cytokines, growth factors, and extracellular vesicles that modulate inflammation, promote angiogenesis, and stimulate tissue repair. These bioactive components interact with the body's immune, cardiovascular, and pulmonary systems. While the exact molecular targets are not fully elucidated, the extract influences signaling pathways related to inflammation, fibrosis, and cell differentiation. The bioavailability of the extract depends on its formulation, with MSCs or their derivatives typically administered via injection in research settings to bypass the digestive system and ensure direct delivery to target tissues.
Side effects
The safety profile of porcine mesenchyme aqueous extract in humans is not well-established due to limited human data. While MSC therapies in animal models are generally well-tolerated, the extract may cause mild immune reactions. Potential risks include immune sensitization or rejection, particularly in xenogeneic use. Drug interactions are not established, and contraindications are unknown. Caution is advised for individuals who are immunocompromised or have known allergies. Due to the lack of comprehensive safety data, special population considerations are not yet defined. Further research is needed to fully assess the potential adverse effects and safety risks associated with the use of this extract in humans.
Dosage
There is currently no established minimum effective dose, optimal dosage range, or maximum safe dose for porcine mesenchyme aqueous extract. Research studies typically use cell counts (e.g., millions of MSCs) rather than extract concentration to determine dosage. Benefits observed in animal studies typically occur within days to weeks post-treatment. The extract is typically administered via injection in research settings, and oral or topical use has not been extensively studied. Absorption factors are unknown, and no required cofactors have been reported. Due to the lack of human clinical trials, specific dosing guidelines cannot be provided, and caution is advised.
FAQs
Is Porcine Mesenchyme Aqueous Extract 125x safe for human use?
There is insufficient clinical safety data available for human use. Therefore, caution should be exercised.
How does it work?
It likely works through bioactive factors released from MSCs, which promote tissue repair and modulate the immune system.
When can benefits be expected?
Animal studies have shown effects within days to weeks of treatment, but human data is lacking.
Is it the same as stem cell therapy?
No, it is an extract derived from stem cells, not live cells themselves. It contains components released by the cells.
Can it replace conventional treatments?
There is no clinical evidence to support the use of this extract as a replacement for conventional medical treatments.
Research Sources
- https://www.mdpi.com/2076-2615/12/6/749 – This meta-analysis of preclinical studies in large animal models, including swine, found that stem cell therapy, including porcine MSCs, significantly improved heart function in ischemic injury models. The study highlights the potential of MSCs in cardiac regeneration, but notes the heterogeneity in methods across studies as a limitation.
- https://www.jove.com/t/63785/isolation-identification-porcine-bone-marrow-mesenchymal-stem-cells – This study details the methods for isolating and characterizing porcine bone marrow MSCs. It establishes protocols for cell culture and differentiation, demonstrating the multipotency and regenerative potential of these cells in vitro and in animal models, but lacks clinical data.
- https://www.mdpi.com/2073-4409/12/2/268 – This research focuses on the isolation and characterization of porcine bone marrow MSCs, demonstrating their ability to differentiate and regenerate tissues. The study provides valuable insights into the cellular biology of porcine MSCs but does not include clinical data or human trials.
- https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0194748 – This systematic review and meta-analysis of preclinical studies found that MSCs significantly improved survival and reduced lung edema and fibrosis in animal models of paraquat-induced lung injury. The study provides strong preclinical evidence for the efficacy of MSCs in treating lung injury, but acknowledges variability in MSC sources and protocols as a limitation.