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Poria Sclerotium Extract

Also known as: Poria mushroom, Indian bread, Poria cocos

Overview

Poria cocos, commonly known as Poria mushroom or Indian bread, is a fungus whose sclerotia are utilized in traditional medicine. It grows on the roots of pine trees and contains bioactive compounds such as triterpenes and sterols. Traditionally, it has been used for various health conditions, including sleep disorders and immune system modulation. Research on Poria cocos is still emerging, with some clinical trials showing promising results, particularly in improving sleep quality. However, more systematic reviews are needed to verify these findings. The available evidence suggests moderate efficacy, with some studies indicating statistically significant improvements in sleep parameters. Ethanol extracts are commonly used in supplements.

Benefits

Poria cocos primarily improves sleep quality by increasing total sleep time and reducing wakefulness during sleep. A clinical study demonstrated a significant increase in sleep duration and a decrease in arousal during sleep. Secondary benefits include potential positive effects on osteoporosis due to its influence on osteoblast differentiation, as indicated by in vitro studies. These benefits may be particularly relevant for individuals with insomnia. While statistically significant improvements in sleep parameters have been observed, further research is necessary to establish clinical significance across diverse conditions. Some benefits have been noted within a few days of use, with more substantial improvements appearing after two weeks.

How it works

Poria cocos modulates immune function and may influence neurotransmitter activity related to sleep. It interacts with the central nervous system and potentially the skeletal system through osteoblast differentiation. The compounds in Poria cocos may interact with receptors involved in sleep regulation and bone metabolism. However, limited data is available on the absorption and bioavailability of its active components. Further research is needed to fully elucidate the mechanisms of action and the specific molecular targets involved.

Side effects

Poria cocos is generally considered safe, but there is limited reliable information on long-term use. Allergic reactions may occur in sensitive individuals. Uncommon and rare side effects are not well-documented. Poria cocos may interact with sedatives and anticholinergic drugs, potentially enhancing their effects. It is contraindicated for use before surgery due to potential CNS effects. Due to a lack of safety data, it should be avoided during pregnancy and breastfeeding. Consult with a healthcare provider before use, especially if taking other medications or having pre-existing health conditions.

Dosage

Studies have used 800 mg of Poria cocos extract nightly for sleep improvement. However, the minimum effective dose and maximum safe dose have not been definitively established. For sleep benefits, it is typically taken before bedtime. Ethanol extracts are commonly used. Limited data is available on absorption factors and required cofactors. Consult with a healthcare provider to determine the appropriate dosage for individual needs and to ensure safety. Due to limited research, it is important to adhere to recommended dosages and monitor for any adverse effects.

FAQs

How should I take Poria cocos for sleep?

Take Poria cocos before bedtime. Studies have used 800mg of Poria cocos extract nightly for sleep improvement. Consult with a healthcare provider before use, especially if taking other medications.

Is Poria cocos safe during pregnancy?

Avoid use during pregnancy and breastfeeding due to a lack of safety data. Consult with a healthcare provider for alternative options.

How quickly can I expect to see results?

Improved sleep quality may be observed within a few days to weeks. Individual results may vary. Consult with a healthcare provider if you have any concerns.

Can Poria cocos replace my current medications?

Poria cocos is not a substitute for medical treatment without consulting a healthcare provider. Always follow the advice of your healthcare provider.

Are there any known drug interactions?

Poria cocos may interact with sedatives and anticholinergic drugs. Consult with a healthcare provider before use, especially if taking other medications.

Research Sources

https://www.mdpi.com/2072-6643/15/19/4242 – This study investigates the impact of Poria cocos on sleep quality. The research indicates that Poria cocos can significantly improve sleep duration and reduce arousal during sleep, suggesting its potential as a natural sleep aid. The findings support the traditional use of Poria cocos for sleep disorders.
https://pubmed.ncbi.nlm.nih.gov/37836526/ – This study explores the effects of herbal medicines, including Poria, on various health conditions. The review suggests that herbal medicines may offer benefits, but emphasizes the need for more rigorous and specific studies to validate these claims. The research highlights the potential of Poria while acknowledging the limitations of current evidence.
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1230604/full – This study provides a comprehensive review of herbal medicines and their pharmacological activities. It highlights the potential benefits of various herbal remedies, including Poria cocos, while emphasizing the need for further research to validate their efficacy and safety. The review underscores the importance of rigorous scientific investigation in the field of herbal medicine.
https://pubmed.ncbi.nlm.nih.gov/30092384/ – This biochemical analysis focuses on isolating bioactive compounds from Poria cocos with potential osteogenic effects. The in vitro study identifies compounds that may promote osteoblast differentiation, suggesting a potential benefit for osteoporosis. However, the results require in vivo verification to confirm their clinical relevance.
https://www.webmd.com/vitamins/ai/ingredientmono-246/poria-mushroom – This WebMD article provides a general overview of Poria mushroom, including its uses, benefits, and potential side effects. It serves as a basic informational resource for consumers interested in learning more about Poria cocos. The article highlights the traditional uses of Poria and summarizes available information on its safety and efficacy.