Portusana
Also known as: Purslane, Portusana, Portulaca oleracea
Overview
Portusana is a supplement ingredient derived from *Portulaca oleracea*, commonly known as purslane, a leafy succulent plant with a long history of use as both a food and medicinal herb. This botanical extract is primarily investigated for its potential to improve metabolic health parameters. Research indicates its involvement in glycemic control, reduction of oxidative stress, and positive effects on obesity indices and cardiovascular risk factors. The evidence base for purslane is growing, supported by multiple randomized controlled trials (RCTs) and several systematic reviews and meta-analyses, though studies can be heterogeneous in design. It is categorized as a herbal supplement and functional food ingredient.
Benefits
Purslane supplementation has demonstrated several evidence-based benefits, particularly for individuals with metabolic risk factors. Meta-analyses of 16 RCTs (n=1122) show a significant reduction in fasting blood sugar (FBS) and the oxidative stress marker malondialdehyde (MDA), alongside an increase in total antioxidant capacity (TAC). However, effects on HbA1c, fasting insulin, and HOMA-IR were not statistically significant. For obesity-related outcomes, systematic reviews and meta-analyses report modest but significant reductions in body weight (approximately −0.94 kg) and BMI (approximately −0.53 kg/m²), though no significant effect on waist circumference was observed. Purslane intake also significantly reduces systolic blood pressure (SBP) but does not affect diastolic blood pressure (DBP). Some evidence suggests potential improvements in blood lipid profiles, though this area requires further conclusive research. These benefits are most consistently observed in adults with metabolic syndrome, type 2 diabetes, or overweight/obesity.
How it works
Purslane's beneficial effects are largely attributed to its rich composition of bioactive compounds, including antioxidants such as flavonoids, omega-3 fatty acids, and vitamins C and E. These compounds work by reducing oxidative stress and inflammation, which are key contributors to metabolic dysfunction. By mitigating oxidative damage, purslane may help improve glycemic control, potentially by enhancing glucose uptake and protecting pancreatic beta cells. Its anti-inflammatory properties are also thought to contribute to improved blood pressure regulation and favorable lipid profiles. The bioavailability of these active compounds can vary depending on the preparation form, with aqueous extracts and powders being common delivery methods.
Side effects
Purslane is generally considered safe for consumption, with randomized controlled trials reporting negligible adverse effects. When side effects do occur, they are rare and typically mild, such as minor gastrointestinal discomfort. There have been no significant drug interactions or contraindications documented in high-quality studies to date. However, it is important to note that there is insufficient data to make definitive safety conclusions for special populations, including pregnant women and children. As with any supplement, individuals with pre-existing health conditions or those taking medications should consult a healthcare professional before starting supplementation.
Dosage
Effective doses of purslane in clinical trials vary considerably, typically ranging from 100 mg to several grams per day, whether as an extract or powder. An optimal dosing regimen is not yet firmly established, but many studies demonstrating benefits have utilized dosages of 1–2 grams per day, administered for durations of 8–12 weeks. It is generally recommended to take purslane daily with meals, which may enhance absorption and help minimize any potential gastrointestinal discomfort. While no specific cofactors are strictly required for its efficacy, there is a possibility that its antioxidant effects could be synergistically enhanced when taken alongside other vitamins or antioxidants. Upper limits and safety thresholds for long-term use are not fully defined.
FAQs
Is Portusana safe for long-term use?
Current evidence supports its safety for up to 12 weeks of use; however, data on longer-term safety and efficacy are presently limited.
How soon can benefits be expected?
Noticeable benefits, particularly regarding glycemic control and weight management, typically begin to appear after 8–12 weeks of consistent supplementation.
Does it replace diabetes medication?
No, purslane should be considered an adjunct therapy to support metabolic health, not a substitute for prescribed diabetes medications or standard medical care.
Are all purslane supplements equivalent?
No, there can be significant variability in the standardization and concentration of active compounds across different purslane supplements, which may affect their efficacy.
Research Sources
- https://onlinelibrary.wiley.com/doi/abs/10.1002/fsn3.3311 – This systematic review and meta-analysis of 16 RCTs (n=1122) found that purslane significantly reduced fasting blood sugar (FBS) and malondialdehyde (MDA), and increased total antioxidant capacity (TAC). However, it showed no significant effect on HbA1c, fasting insulin, or HOMA-IR, despite moderate heterogeneity among studies.
- https://www.cambridge.org/core/journals/journal-of-nutritional-science/article/effects-of-purslane-consumption-on-blood-pressure-body-weight-body-mass-index-and-waist-circumference-a-systematic-review-and-metaanalysis-of-randomised-controlled/59694EFDDBE18E1B823C94273E7BC87B – This systematic review and meta-analysis reported that purslane supplementation significantly reduced body weight, BMI, and systolic blood pressure (SBP). It found no significant effect on waist circumference (WC) or diastolic blood pressure (DBP), noting a limited number of studies for some outcomes.
- https://pubmed.ncbi.nlm.nih.gov/30281177/ – This systematic review and meta-analysis suggested potential improvements in blood lipids and glucose levels with purslane supplementation. The study acknowledged limitations due to heterogeneity among included trials and varying sample sizes, indicating a need for further research to confirm these effects definitively.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC10261734/ – This meta-analysis, focusing on the effects of Portulaca oleracea on obesity, confirmed significant reductions in body weight and BMI. It supports the role of purslane in managing obesity-related outcomes, contributing to the growing evidence base for its metabolic benefits.
