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Preforpro

Also known as: PreforPro, Phage supplement, LH01-Myoviridae, LL5-Siphoviridae, T4D-Myoviridae, LL12-Myoviridae

Overview

PreforPro is a commercially available bacteriophage cocktail designed to modulate the gut microbiota. It contains a blend of bacteriophages, including LH01-Myoviridae, LL5-Siphoviridae, T4D-Myoviridae, and LL12-Myoviridae, which target specific bacteria within the gut, such as *E. coli*. Bacteriophages are naturally occurring viruses that infect and kill bacteria, thereby influencing the gut's ecological balance. PreforPro is primarily used to enhance the effects of probiotics, potentially improving gastrointestinal health by reducing inflammation and promoting the growth of beneficial bacteria. Research on PreforPro is still in its early stages, but initial clinical trials suggest promising benefits when used in conjunction with probiotics. It is available in various supplement forms, most commonly capsules, and is intended to support overall gut health by selectively targeting and reducing harmful bacteria.

Benefits

PreforPro has shown potential benefits in improving gastrointestinal health, particularly when combined with probiotics like *Bifidobacterium animalis* subsp. *lactis* (*B. lactis*). Studies indicate that this combination can reduce inflammation in the gut and potentially enhance the growth of beneficial bacteria such as *Lactobacillus*. The PHAGE-2 study, a randomized, double-blind, placebo-controlled trial, demonstrated that participants experienced reduced GI inflammation and a trend towards reduced colon pain when using PreforPro with *B. lactis*. These benefits are primarily observed in individuals with gastrointestinal issues, with improvements typically noticeable within a few weeks of supplementation. While the clinical significance is moderate, the observed improvements in GI symptoms suggest a beneficial role for PreforPro in modulating gut microbiota.

How it works

PreforPro functions by selectively targeting and reducing pathogenic bacteria in the gut, which can lead to an increase in beneficial bacteria and an overall improvement in gut health. As a bacteriophage cocktail, it contains viruses that infect specific bacterial strains, such as *E. coli*, leading to their lysis (destruction). This modulation of the gut microbiota can help to restore balance and improve gastrointestinal function. The primary interaction is within the gastrointestinal system, where PreforPro's bacteriophages interact with and alter the composition of the gut microbiota, promoting a healthier gut environment.

Side effects

PreforPro is generally considered safe, with no significant adverse effects reported in the available studies. Common, uncommon, and rare side effects have not been documented in the existing literature. Due to limited information on drug interactions, caution is advised when using PreforPro alongside other medications, and it is recommended to consult with a healthcare provider. There are no well-documented contraindications, but data on its use in special populations like pregnant women or children is limited, warranting caution. Overall, PreforPro appears to have a favorable safety profile based on current research, but further studies are needed to fully assess its safety across diverse populations and in combination with various medications.

Dosage

The effective dose of PreforPro used in studies is typically around 1 x 10^6 Plaque Forming Units (PFU) per day. The optimal dosage range beyond this is not well established, and there is no established maximum safe dose. PreforPro is typically taken once daily, often administered in capsule form. Its effectiveness depends on its ability to reach and interact with the gut microbiota. No specific cofactors are required for its use. While generally considered safe, it is advisable to adhere to the studied dosage and consult with a healthcare provider before starting supplementation.

FAQs

Is PreforPro a probiotic?

No, PreforPro is not a probiotic. It is a bacteriophage cocktail designed to target specific bacteria in the gut, enhancing the effects of probiotics.

How should I take PreforPro?

PreforPro is best taken with probiotics to enhance their effects. It is typically taken once daily, as directed on the product label or by a healthcare provider.

What are the expected results from taking PreforPro?

Users may experience improved gastrointestinal health, such as reduced inflammation and better gut balance, when taking PreforPro in conjunction with probiotics.

Is PreforPro safe?

PreforPro is generally considered safe, but it is advisable to consult with a healthcare provider before starting supplementation, especially if you are taking other medications.

Can PreforPro be taken alone?

PreforPro is designed to enhance probiotic effects and may not be as effective as a standalone supplement. It is best used in combination with a probiotic.

Research Sources

https://pubmed.ncbi.nlm.nih.gov/38064222/ – This study investigated the effects of a bacteriophage cocktail on gut microbiota composition and diversity. The research suggests that bacteriophages can selectively target and reduce specific bacterial populations in the gut, potentially leading to a more balanced gut microbiome. The findings support the use of bacteriophages as a tool to modulate gut health.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7468981/ – This article discusses the potential of bacteriophages in modulating the gut microbiome and their implications for human health. It highlights the mechanisms by which bacteriophages can selectively target and eliminate specific bacteria, thereby influencing the overall composition and function of the gut microbiota. The review suggests that bacteriophages may offer a promising approach for managing gut-related disorders.
https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0278356 – This study explores the impact of a specific bacteriophage on bacterial populations in vitro. The research demonstrates that the bacteriophage effectively targets and lyses its host bacteria, leading to a reduction in bacterial load. The findings provide insights into the potential of bacteriophages as antimicrobial agents.
https://www.nutritionaloutlook.com/view/chicory-root-prebiotic-supplement-shown-to-support-weight-management-study-shows – This article discusses a study on a chicory root prebiotic supplement and its effects on weight management. While not directly related to PreforPro, it provides context on the broader field of gut health and the use of supplements to modulate the gut microbiome. The study suggests that prebiotics can support weight management by influencing gut microbiota composition.
https://www.mdpi.com/2072-6643/14/3/622 – This review examines the role of nutrition in modulating the gut microbiome and its impact on overall health. It discusses various dietary components, including prebiotics and probiotics, and their effects on gut microbiota composition and function. The review highlights the importance of nutrition in maintaining a healthy gut microbiome and preventing gut-related disorders.