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Preforpro Prebiotic Blend

Also known as: PreforPro, bacteriophage prebiotic, bacteriophage cocktail

Overview

PreforPro is a patented blend of bacteriophages, viruses that selectively target and modulate bacteria in the gut, acting as a novel prebiotic. Unlike traditional fiber-based prebiotics, PreforPro is a non-starch, non-fiber compound. It supports gut health by favorably modifying the gut microbiota, potentially reducing inflammation, and improving systemic markers. It is administered in small doses (15mg) and does not require large amounts of starch or fiber to exert its prebiotic effects. Research on PreforPro is relatively recent, including clinical studies, but is still evolving. Available evidence includes randomized, double-blind, placebo-controlled trials. PreforPro is available in capsule form and can be part of a synbiotic blend.

Benefits

PreforPro has demonstrated the ability to favorably modify the gut microbiota in healthy adults with self-reported gastrointestinal distress. A clinical study showed that consumption for 28 days increased populations of beneficial bacterial species such as Eubacterium and reduced the circulating pro-inflammatory cytokine IL-4. The same study found that PreforPro caused minimal disruption to the gut microbiota but elicited minor beneficial changes, including an increase in fermentative taxa capable of butyrate production, suggesting a shift towards a healthier gut environment. In vitro and mouse studies have shown PreforPro enhances the growth of a broad spectrum of probiotic species, including *B. breve*, *L. acidophilus*, *L. paracasei*, *L. casei*, *L. rhamnosus*, and *B. subtilis*.

How it works

PreforPro works by selectively targeting and modulating the gut microbiota through the action of bacteriophages. These bacteriophages infect and lyse specific bacterial species, thereby promoting the growth of beneficial bacteria. This modification of the gut microbiota affects the gastrointestinal system, which in turn can influence lipid metabolism, inflammation, and overall gut health. The bacteriophages in PreforPro target specific bacterial species, leading to changes in the microbial composition and the production of short-chain fatty acids (SCFAs) like butyrate.

Side effects

The available studies indicate that PreforPro is generally safe with minimal disruption to the gut microbiota. No significant adverse effects were reported in the clinical trial using a 15mg dose. There are no reported common, uncommon, or rare side effects in the available studies. There is no specific data on drug interactions, but given its mechanism of action, it is unlikely to interact with most medications. There are no known contraindications, but caution should be exercised in individuals with severe immune deficiencies or those undergoing immunosuppressive therapy. Limited data exists on its use in pregnant women, children, or individuals with severe health conditions, so caution and consultation with a healthcare provider are advised.

Dosage

The minimum effective dose of PreforPro is 15mg per day, as used in the clinical study. The optimal dosage range is not fully established, but 15mg per day has shown efficacy in clinical trials. There is no established maximum safe dose, but the clinical study did not report any adverse effects at the 15mg dose. No specific timing considerations are mentioned in the studies. PreforPro is available in capsule form and can be part of a synbiotic blend. Given its non-fiber nature, absorption is likely not affected by dietary fiber intake. There are no known required cofactors for PreforPro to exert its effects.

FAQs

Is PreforPro safe?

PreforPro is generally considered safe with minimal side effects reported in clinical trials. However, individuals with immune deficiencies should consult a healthcare provider.

When should I take PreforPro?

There are no specific timing recommendations for administration. It can be taken at any time of day, with or without food.

What results can I expect from taking PreforPro?

Users may experience improvements in gut microbiota composition and reductions in inflammatory markers. Individual results may vary.

Is PreforPro a fiber-based prebiotic?

No, PreforPro is not a traditional fiber-based prebiotic. It is a bacteriophage-based prebiotic and does not require large doses to be effective.

Research Sources

https://nutraceuticalbusinessreview.com/deerland-preforpro-effect-on-gut-microbiota-gets-scientific-support-153418 – This article discusses a clinical study on PreforPro, highlighting its ability to favorably modify the gut microbiota in healthy adults with self-reported gastrointestinal distress. The study found that PreforPro increased beneficial bacterial species and reduced inflammatory markers, suggesting a positive impact on gut health.
https://pubmed.ncbi.nlm.nih.gov/38572479/ – This study is a randomized, double-blind, placebo-controlled crossover intervention trial that examined the effects of supplemental bacteriophage intake on inflammation and gut microbiota in healthy adults with self-reported gastrointestinal distress. The results showed that PreforPro consumption favorably modified the gut microbiota, increased beneficial bacterial species, and reduced inflammatory markers.
https://pubmed.ncbi.nlm.nih.gov/30294792/ – This systematic review and meta-analysis examined the effects of prebiotics, probiotics, and synbiotics on various health outcomes. While not specifically focused on PreforPro, it provides context on the broader category of prebiotics and their potential benefits, particularly in relation to overweight/obesity indicators.
https://honehealth.com/edge/prebiotic-supplement/ – This article provides a general overview of prebiotic supplements, including PreforPro. It discusses the benefits of prebiotics for gut health and overall well-being, highlighting their role in supporting a balanced gut microbiota.