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Preticx Xylooligosaccharide

Also known as: PreticX, XOS, Xylooligosaccharide

Overview

Xylooligosaccharides (XOS) are non-digestible oligosaccharides derived from xylan, a component of plant cell walls. As a prebiotic supplement, XOS primarily supports gut health by promoting the growth of beneficial bacteria, most notably *Bifidobacterium*. Found naturally in various plant materials, XOS is often produced industrially for incorporation into dietary supplements and functional foods. This compound has garnered increasing research attention focused on its potential effects on gut microbiota composition and metabolic health, suggesting a promising role in health maintenance and disease prevention.

Benefits

XOS supplementation is associated with several evidence-based benefits. Primary effects include a significant increase in levels of beneficial bacteria like *Bifidobacterium*, which enhances gut health and may support immune function. Secondary effects have indicated potential improvements in metabolic parameters, particularly in prediabetic individuals by optimizing the Firmicutes/Bacteroidetes ratio and reducing harmful bacteria. The greatest benefit appears to be for those with impaired glucose tolerance, showing statistically significant changes in gut microbiota composition. Benefits usually manifest within weeks of consistent use, based on studies lasting 6 to 8 weeks. However, while the increase in beneficial bacteria is statistically significant, the broader clinical implications of these changes require further investigation.

How it works

XOS serves as a prebiotic, fermenting selectively in the colon and catering to beneficial bacteria like *Bifidobacterium*. Through fermentation, XOS produces short-chain fatty acids, which contribute to improved gut health and metabolic benefits. Although the exact molecular pathways and targets of XOS in influencing metabolic health remain unclear, its ability to enhance beneficial gut flora and produce metabolites that support gut function is well-established.

Side effects

Overall, XOS is considered to be well-tolerated with minimal gastrointestinal side effects reported in clinical trials. No common side effects have been consistently documented; however, mild gastrointestinal discomfort could occur in some individuals, albeit rarely. There have been no rare side effects reported. Importantly, no significant drug interactions have been identified, and there are no established contraindications for its use. XOS appears to be safe for healthy adults and prediabetic individuals, though data on its use in pregnant or lactating women and other vulnerable populations is limited, warranting caution.

Dosage

The minimum effective dose of XOS is approximately 1 gram per day, while optimal dosage ranges between 1 to 2.8 grams daily, potentially yielding greater benefits in gut microbiota modulation at higher doses. While no maximum safe dose has been established, doses up to 2.8 grams have been administered without significant adverse effects. There are no specific timing recommendations for XOS intake, allowing for flexibility in consumption with meals or as directed. XOS is available in various forms, such as capsules and powders, which may influence absorption and usage considerations.

FAQs

Is XOS safe for long-term use?

Short-term studies indicate XOS is well-tolerated, but there is limited data on its long-term safety.

Can XOS help with weight management?

Some evidence suggests XOS may reduce visceral fat when combined with probiotics, but more research is necessary.

How quickly does XOS start working?

Benefits of XOS supplementation typically begin to manifest within a few weeks.

Research Sources

https://pubmed.ncbi.nlm.nih.gov/24513849/ – This study demonstrated that XOS increases *Bifidobacterium* counts without significant side effects, supporting its role as a prebiotic; however, it did not reveal significant impacts on other bacteria or metabolic parameters.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4528259/ – This investigation found that XOS supplementation improved gut microbiota profiles in both healthy and prediabetic individuals, with no reported adverse effects, highlighting its potential metabolic benefits.
https://futureofmicrobiome.com/wp-content/uploads/2021/03/AIDP-Digestive-Brochure-7-20-compressed.pdf – Research involving PreticX, a specific brand of XOS, indicated its effectiveness in altering gut bacteria composition and metabolic health improvements in prediabetic populations, although further verification is required.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5019895/ – This study examined the digestive health benefits of XOS, noting its favorable impact on gut microbiota with an emphasis on safety and tolerance.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9703693/ – This meta-analysis discussed the prebiotic benefits of XOS, providing insights into its role in improving gut flora and potential interactions with metabolic health factors.