Prolensis
Also known as: Bulbine natalensis, ProLensis™, Rooiwortel
Overview
Bulbine natalensis, marketed as ProLensis™, is a succulent plant extract from South Africa, promoted as a natural testosterone support supplement. However, current research on its efficacy is limited and primarily consists of early-stage studies. The available evidence, including one randomized controlled trial, does not support claims of significant testosterone-boosting effects. The extract contains various compounds, including anthraquinones, saponins, and alkaloids, but its specific composition and bioavailability remain largely uncharacterized. While short-term safety data suggests no serious adverse effects, long-term safety and efficacy are unknown. Given the lack of robust evidence, its use for hormonal modulation is not currently justified.
Benefits
The primary marketed benefit of Bulbine natalensis (ProLensis™) is testosterone enhancement. However, a randomized controlled trial (RCT) involving 36 healthy men found no significant changes in testosterone levels after 28 days of supplementation. Secondary effects observed in the same study included a marginal decrease in creatinine levels (-7.4% compared to placebo, p<0.003) and clinically insignificant changes in alkaline phosphatase levels (+3% vs -3.8% placebo). All biomarker levels remained within normal ranges, and no performance-enhancing effects were demonstrated. Overall, current evidence does not support the use of Bulbine natalensis for any clinically relevant benefits.
How it works
The hypothesized mechanism of action for Bulbine natalensis involves potential modulation of androgen receptors, primarily based on animal studies. However, the specific molecular targets and biological pathways in humans remain unconfirmed. No pharmacokinetic studies have been conducted to determine its bioavailability. The absorption characteristics of Bulbine natalensis are also uncharacterized, although trials have used capsule forms of standardized extracts. Further research is needed to elucidate the precise mechanisms by which Bulbine natalensis may interact with the endocrine system.
Side effects
Short-term safety data from a 28-day randomized controlled trial indicates no serious adverse events or hematological/renal abnormalities associated with Bulbine natalensis supplementation. However, long-term safety remains unknown due to the absence of studies exceeding four weeks in duration. As a precaution, Bulbine natalensis is contraindicated in individuals with hormone-sensitive conditions due to theoretical risks. No data are available regarding its safety during pregnancy or lactation. Given the limited research, potential drug interactions are also unknown. Comprehensive safety assessments, including long-term studies and evaluations in diverse populations, are necessary to fully characterize the side effect profile of Bulbine natalensis.
Dosage
The studied dosage of Bulbine natalensis (ProLensis™) in the primary randomized controlled trial was 650 mg per day, administered in two divided doses of 325 mg each. The optimal dosage for any potential benefit remains undetermined, as no clinically relevant effects have been demonstrated. The maximum duration tested in clinical trials is 28 days. The form used in studies is a standardized extract, although the specific standardization process is unclear. Due to the lack of comprehensive safety data, upper limits and safety thresholds have not been established. Further research is needed to determine appropriate dosing guidelines.
FAQs
Does it boost testosterone?
No human evidence supports the claim that Bulbine natalensis elevates testosterone levels. Clinical trials have not demonstrated any significant increase in testosterone following supplementation.
Is it safe for athletes?
There is insufficient safety data to determine whether Bulbine natalensis is safe for athletic populations. More research is needed to assess potential risks and benefits in athletes.
How long until results?
No measurable benefits have been demonstrated in clinical trials. Therefore, there is no evidence to suggest that Bulbine natalensis produces any noticeable results.
Research Sources
- https://pmc.ncbi.nlm.nih.gov/articles/PMC3500755/ – This randomized, placebo-controlled, double-blind study examined the effects of Bulbine natalensis on 36 healthy men over 28 days. The findings revealed no clinically relevant changes in 27 out of 29 biomarkers, suggesting limited impact on physiological parameters. The study's limitations include a small sample size, short duration, and the absence of hormonal measures, indicating a need for more comprehensive research.
- https://www.mdpi.com/2673-396X/2/2/11 – This systematic review assessed 14 testosterone booster ingredients and concluded that there is insufficient evidence for the efficacy and safety of herbal testosterone boosters. The review highlights the heterogeneity of study designs as a limitation, emphasizing the need for standardized research methodologies. The review follows PRISMA guidelines, ensuring a rigorous and transparent approach to evidence synthesis.
- https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2024.1464959/full – This review focuses on supplements for hormonal balance but does not mention Bulbine natalensis, highlighting the evidence gaps for herbal interventions in this area. The broad scope of the review limits its depth, but it underscores the need for more targeted research on specific herbal supplements. The review provides a general overview of the current state of supplement research for hormonal balance.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC8166567/ – This MDPI systematic review examined various testosterone booster ingredients, concluding that the evidence supporting the efficacy and safety of herbal testosterone boosters is insufficient. The review points out the heterogeneity in study designs as a significant limitation, emphasizing the necessity for standardized research methodologies. The review adheres to PRISMA guidelines, ensuring a rigorous and transparent approach to evidence synthesis.
- https://onlinelibrary.wiley.com/doi/full/10.1002/fsn3.2887 – This study investigates the effects of commonly consumed herbs and spices on human health, focusing on their potential to modulate gut microbiota and influence metabolic health. While it doesn't specifically address Bulbine natalensis, it provides a broader context for understanding the complex interactions between herbal compounds and human physiology. The research highlights the need for further investigation into the mechanisms of action and clinical relevance of various herbal interventions.