Propionibacterium Freudenreichii Mak10p23f
Also known as: Swiss cheese bacteria, Propionibacterium, P. freudenreichii, Propionibacterium freudenreichii
Overview
*Propionibacterium freudenreichii* is a probiotic bacterium predominantly recognized for its role in Swiss cheese production. It contributes to the unique flavor and texture of the cheese while also being acknowledged for its health-promoting properties. This strain not only helps in modulating gut microbiota but also produces essential nutrients including vitamins B9 and B12, as well as short-chain fatty acids such as acetate and propionate. *Propionibacterium freudenreichii Mak10p23f* has demonstrated potential health benefits but lacks extensive research-specific literature; nonetheless, studies indicate its immunomodulatory properties and a moderate level of research maturity concerning its probiotic effects. The efficacy of this strain in enhancing gut health and reducing inflammation appears promising, but more systematic studies are warranted.
Benefits
- **Primary Effects**: *P. freudenreichii* enhances gut microbiota diversity, modulates immune responses, and exhibits anti-inflammatory properties. Noteworthy research demonstrates its ability to inhibit the growth of colorectal cancer cells and reduce aberrant crypt foci in animal models. - **Secondary Effects**: This bacterium may support individuals with inflammatory bowel diseases and promote beneficial bifidobacteria growth. - **Population-Specific Benefits**: Particularly beneficial for individuals dealing with gut health issues or those looking to boost their immune system. - **Effect Sizes and Clinical Significance**: While specific effect sizes for *Mak10p23f* are not well-documented, existing studies suggest significant impacts on gut health and inflammation management.
How it works
*P. freudenreichii* operates through the production of beneficial metabolites, such as different acids, which can positively affect the growth of bifidobacteria while modulating immune system functions. The interaction with the gut microbiota and enhancement of gut barrier properties is facilitated through these metabolites, promoting a healthier microbial environment while mitigating inflammation.
Side effects
Overall, *P. freudenreichii* is generally considered safe and has been granted 'Generally Recognized as Safe' (GRAS) status by the FDA. Common side effects tend to be mild, typically involving gastrointestinal discomfort. Rarely, systemic infections can occur in immunocompromised individuals. There are no significant drug interactions reported, making it a relatively low-risk supplement for healthy individuals. Nonetheless, caution is advised for those with severely compromised immune systems, as probiotics including *P. freudenreichii* can pose risks during certain medical conditions.
Dosage
While no specific minimum effective dose has been established for *P. freudenreichii Mak10p23f*, typical dosages for probiotics range from 10^8 to 10^10 CFU per day. Higher doses within this range are often seen to yield optimal effects. Though the maximum recommended doses remain undefined, most probiotics are considered safe even at higher intake levels, suggesting good tolerance.
FAQs
How should I store *P. freudenreichii* supplements?
Ensure proper storage in a cool, dry place to maintain the viability of the probiotic strains.
Is *P. freudenreichii* safe for everyone?
Generally safe, but individuals who are immunocompromised should consult a healthcare provider before use.
When is the best time to take it?
Taking it with meals may enhance tolerance and efficacy.
What results can I expect?
Improved gut health and immune function typically noted over several weeks of regular use.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/8182163/ – This study examines the bifidogenic effects of *P. freudenreichii*, identifying its role in stimulating bifidobacteria growth, contributing positively to gut health.
- https://pubmed.ncbi.nlm.nih.gov/25150945/ – This research outlines the immunomodulatory properties of *P. freudenreichii*, detailing how its surface proteins interact with intestinal cells and influence immune responses.
- https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2019.02324/full – This article discusses the anti-cancer effects of *P. freudenreichii*, highlighting its potential to inhibit aberrant crypt foci in colorectal cancer models, indicating broader therapeutic benefits.
- https://pubmed.ncbi.nlm.nih.gov/37175785/ – A systematic review on the various health benefits associated with *P. freudenreichii*, including its health-promoting capabilities and areas requiring further research.