Get Your Personalized Supplement StackSupplement Stack Quiz

Proprietary Acidophilus Blend

Also known as: Acidophilus blend, Probiotic blend, Lactobacillus blend, *Lactobacillus rhamnosus*, *Lactobacillus casei*, *Lactobacillus acidophilus*

Overview

*Lactobacillus acidophilus* is a species of beneficial bacteria classified under probiotics. These live microorganisms are known for their health benefits, particularly in gut health, digestion, and immune support. Commonly found in fermented foods such as yogurt and kefir, *Lactobacillus acidophilus* is also naturally present in the human gut. Probiotic supplements featuring this strain aim to restore and maintain healthy gut flora, and are often combined with other strains for enhanced efficacy. While extensive research has demonstrated various health benefits, including cholesterol management and diarrhea reduction, the quality of the evidence remains varied, often requiring more strain-specific studies for clearer benefits. Additionally, consumption of probiotics must ensure that these bacteria are alive and present in adequate amounts to confer their expected therapeutic effects.

Benefits

Research on *Lactobacillus acidophilus* highlights several evidence-based benefits. A meta-analysis reported modest reductions in total cholesterol and low-density lipoprotein cholesterol levels, making it particularly beneficial for individuals with hypercholesterolemia, with a mean LDL-C reduction of -0.13 mmol/L. The strain also plays a significant role in managing diarrhea, particularly in children, showing a mean reduction in duration of diarrhea by -0.83 days when high doses (≥10^10 CFU/day) are used. Other benefits include support for immune system functioning and improved gut health through enhanced microbiota balance, although evidence for these effects varies by strain and application.

How it works

Probiotics like *Lactobacillus acidophilus* act by colonizing the gastrointestinal tract, promoting a healthy balance of gut microbiota. They produce metabolites, such as short-chain fatty acids, which benefit metabolism and immune functions. The strain influences the gut-brain axis and modulates immune responses via interaction with specific receptors (e.g., Toll-like receptors) that impact both local and systemic immunity. This multifaceted interaction supports nutrient absorption and potentially influences overall wellness.

Side effects

Generally, *Lactobacillus acidophilus* is considered safe for most populations. Common side effects observed in more than 5% of users include mild gastrointestinal discomfort such as bloating, gas, and abdominal pain. Less frequent adverse effects (1-5%) may include allergic reactions. While rare (less than 1%), serious complications can arise in immunocompromised individuals. Caution is also advised when used alongside immunosuppressive medications. Contraindications exist for critically ill patients or those with severe immunodeficiency, and special consideration should be given to pregnant women, children, and older adults, who should seek medical advice before use.

Dosage

The effective dosage of *Lactobacillus acidophilus* varies with individual conditions and the strains used. Generally, a minimum effective dose of 10^9 to 10^10 CFU/day is recommended, particularly for managing cholesterol levels and diarrhea. Higher dosages (≥10^10 CFU/day) may provide added benefits for diarrhea management. While no maximum safe dose is established, doses above 10^11 CFU/day are less commonly used. Probiotics can be consumed at any time, but taking them with food may enhance bacterial survival. The form (capsules, powders, fermented foods) affects absorption, with capsules typically offering better protection from stomach acids.

FAQs

Are probiotics safe?

Generally, yes. Probiotics are safe for most individuals; however, those with compromised immune systems should consult healthcare providers.

When is the best time to take probiotics?

Probiotics can be taken at any time, but taking them with meals may enhance the survival of beneficial bacteria.

When can I expect results from probiotics?

Results vary by strain and condition; lipid profile improvements can take weeks, while diarrhea benefits may be noticeable within days.

Are all probiotics the same?

No, different strains have unique effects. It’s essential to choose a probiotic based on the specific health benefit you desire.

Research Sources

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2812728 – This meta-analysis evaluated 11 articles, both using fermented products and probiotic capsules, showing significant reductions in total and LDL cholesterol levels in relevant populations.
https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0139795 – This systematic review focused on *Lactobacillus acidophilus*, finding that high doses significantly reduced the duration of diarrhea among children and adults.
https://www.mdpi.com/2072-6643/14/3/682 – A systematic review underscoring the importance of strain-specific efficacy, indicating significant effectiveness for certain strains in preventing adverse events like antibiotic-associated diarrhea.
https://pubmed.ncbi.nlm.nih.gov/37004873/ – This study discusses strain-specific benefits of probiotics, emphasizing the significant role of selection in determining health outcomes.
https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2018.00124/full – A comprehensive analysis presenting current evidence of probiotics’ effects on various health conditions, emphasizing the need for rigorous strain-specific evaluations.