Feel Great Proprietary Antioxidant Blend
Also known as: Feel Great Proprietary Antioxidant Blend, Feel Great supplement, proprietary antioxidant blend, Proprietary Antioxidant Blend
Overview
A Proprietary Antioxidant Blend, such as the 'Feel Great Proprietary Antioxidant Blend', refers to a dietary supplement formulated with a combination of various antioxidant compounds. These blends are designed to neutralize reactive oxygen species (ROS) and mitigate oxidative damage to cells and tissues, which is a key factor in aging and various chronic diseases. Common components often include well-known antioxidants like vitamins C and E, polyphenols (e.g., resveratrol), carotenoids (e.g., beta-carotene, lycopene), and plant extracts such as green tea and pomegranate. The primary objective of these blends is to reduce oxidative stress, improve skin health, support metabolic and cardiometabolic functions, and potentially reduce inflammation. A significant characteristic of proprietary blends is that the exact chemical constituents and their precise quantities are typically undisclosed by the manufacturer, which can limit independent assessment of their efficacy and safety. The 'Feel Great' program, for instance, integrates such a blend with lifestyle interventions like intermittent fasting, aiming for synergistic health benefits. While individual antioxidants are extensively researched, the scientific understanding of specific proprietary blends is often constrained by this lack of transparency, with research maturity being moderate and quality of evidence limited by the undisclosed formulations.
Benefits
Proprietary Antioxidant Blends show promising benefits, particularly in skin health and metabolic regulation. A 12-week pilot study on a topical antioxidant blend demonstrated significant improvements in skin parameters, including a 24% reduction in erythema, 22% in wrinkles, 29% in skin tone, 28% in pores, and 31% in brightness, with high statistical significance (p < 0.01 to p < 0.0001) and good tolerability. These skin benefits were observed as early as 4 weeks and sustained throughout the 12-week study period. For metabolic health, a 60-day clinical study of the 'Feel Great' program, which combines oral supplementation with intermittent fasting, reported significant improvements in cardiometabolic markers. These included reductions in blood lipids, triglycerides, HbA1c, body weight, and waist circumference. Additionally, acute supplementation with the 'Feel Great' blend reduced glycemic variability by 12%, which is a clinically relevant outcome for diabetes management. Secondary benefits, such as improved antioxidant status in tissues and prevention of weight gain, have been observed with components like yerba maté (Unimate) within the 'Feel Great' program, suggesting enhanced cellular energy metabolism and protection against oxidative stress. These benefits are particularly relevant for adults with metabolic risk factors or concerns about skin aging. While promising, the evidence for proprietary blends is often limited by their undisclosed formulations and the combined nature of interventions in some studies.
How it works
Antioxidant blends primarily function by neutralizing reactive oxygen species (ROS), which are unstable molecules that can cause oxidative damage to lipids, proteins, and DNA within cells. By scavenging these free radicals, the blends reduce cellular stress and inflammation, thereby improving overall tissue function. This mechanism impacts various body systems, including the skin, where reduced oxidative damage leads to improved appearance and barrier function. In metabolic tissues (muscle, fat, liver) and the cardiovascular system, the reduction in oxidative stress contributes to better lipid and glucose metabolism. Key molecular targets include free radicals, ROS, and inflammatory mediators. Individual antioxidants like vitamins C and E often work synergistically, with vitamin C regenerating vitamin E radicals, enhancing their combined efficacy. Polyphenols, commonly found in these blends, modulate signaling pathways related to oxidative stress and inflammation. While absorption and bioavailability vary among compounds, synergistic combinations are believed to enhance the overall effectiveness of the blend.
Side effects
Proprietary Antioxidant Blends are generally well-tolerated in clinical studies, with no serious adverse events reported. The most commonly reported side effect, observed in a study involving a topical antioxidant blend, was mild dryness in one subject. Uncommon or rare side effects have not been significantly documented for these specific proprietary blends. However, due to the undisclosed nature of their exact compositions, potential drug interactions are not specifically studied. General caution is advised regarding potential interactions with anticoagulants or other medications metabolized via oxidative pathways, as some individual antioxidant components might have such effects. Contraindications are largely unknown due to the proprietary nature of these blends; therefore, standard caution is recommended for pregnant or nursing women, individuals with pre-existing medical conditions, and those on multiple medications. Data on safety in special populations, such as children or individuals with severe chronic illnesses, are limited or unestablished, necessitating a cautious approach in these groups.
Dosage
The minimum effective dose and optimal dosage ranges for proprietary antioxidant blends are typically not disclosed due to their proprietary nature. Clinical studies involving these blends generally use the marketed product as directed by the manufacturer. For instance, the 'Feel Great' program involves oral supplementation combined with lifestyle interventions like intermittent fasting. For topical applications, such as those studied for skin benefits, once-daily application has shown positive results. The maximum safe dose for these blends has not been formally established. Timing of supplementation is generally daily, as recommended in studies. Absorption factors can be influenced by the synergistic combination of antioxidants, which may improve overall bioavailability and efficacy. It's also noted that certain cofactors, such as vitamin C regenerating vitamin E radicals, are important for the combined effectiveness of various antioxidants within the blend. Due to the lack of specific dosing information, users should adhere to the manufacturer's recommendations on the product label.
FAQs
Is the proprietary blend transparent?
No, proprietary blends typically do not disclose the exact amounts of each ingredient, which limits precise evaluation of their composition and efficacy.
Are the benefits clinically proven?
Some clinical evidence supports benefits for skin and metabolic health, but independent verification and ingredient-specific data are often lacking due to the proprietary nature and combined interventions.
Is it safe for long-term use?
Short-term use appears safe based on available studies; however, sufficient long-term safety data are not yet available to confirm extended use safety.
Does it interfere with exercise adaptations?
Evidence on antioxidants blunting exercise adaptations, particularly hypertrophy, is inconclusive. Moderate antioxidant intake is generally considered safe and unlikely to interfere significantly.
How soon will results appear?
Skin improvements have been reported within 4 weeks, and metabolic benefits typically appear within 60 days of consistent use as part of a program.
Research Sources
- https://pmc.ncbi.nlm.nih.gov/articles/PMC8457217/ – This pilot randomized controlled trial (n=22) investigated a topical antioxidant blend over 12 weeks, demonstrating significant improvements in skin parameters such as tone (29%), pores (28%), wrinkles (22%), and erythema (24%) with high statistical significance (p < 0.01). The blend was well-tolerated with no serious adverse events, suggesting its potential for skin health. Limitations include the small sample size and pilot design.
- https://www.unicityscience.org/clinical-validation-studies/ – A clinical trial on the Unicity Feel Great Program (oral supplementation plus intermittent fasting) over 60 days reported improvements in cardiometabolic markers, including reductions in blood lipids, HbA1c, and body weight. It also noted a 12% reduction in glycemic variability. The study suggests antioxidant and metabolic benefits, but limitations include the proprietary blend, combined intervention, and lack of a fully peer-reviewed publication.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC5514576/ – This systematic review on antioxidants in dermatology highlights the amplified effects of combined antioxidant use in addressing skin oxidative stress and inflammation. It emphasizes the synergy between compounds like vitamins C and E and polyphenols, recommending clinical evaluation for specific combinations. The review provides general support for antioxidant benefits but is not specific to proprietary blends.
- https://swolverine.com/blogs/blog/what-is-a-proprietary-blend-5-reasons-to-avoid-proprietary-blends-at-all-costs – This source discusses the general issues with proprietary blends in supplements, primarily focusing on the lack of transparency regarding exact ingredient amounts. It argues that this opacity limits precise evaluation of efficacy and safety, making it difficult for consumers and researchers to understand the true composition and potential effects of such products.
- https://www.strongerbyscience.com/antioxidants/ – This article discusses the relationship between antioxidant supplementation and exercise adaptations, particularly hypertrophy. It suggests that the evidence on antioxidants blunting exercise-induced adaptations is inconclusive, implying that moderate antioxidant intake is generally safe and unlikely to significantly interfere with training outcomes.
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