Proprietary Blend Of 10 Probiotic Bacteria
Also known as: Probiotic Blend, Probiotic Supplement, Gut Health Supplement, Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus rhamnosus, Bifidobacterium bifidum, Saccharomyces boulardii, Probiotic Blend of 10 Bacteria
Overview
A proprietary blend of 10 probiotic bacteria comprises live microorganisms that, when administered in adequate amounts, provide health benefits. These probiotics are typically sourced from fermented foods like yogurt, kefir, and sauerkraut. Their primary applications include prevention and treatment of gastrointestinal disorders such as antibiotic-associated diarrhea (AAD), irritable bowel syndrome (IBS), and constipation. Probiotics are strain-specific; different strains confer different benefits. The efficacy of these blends is supported by numerous systematic reviews and high-quality meta-analyses, demonstrating their role in maintaining gut health and reducing bowel-related symptoms.
Benefits
Evidence-based benefits of this probiotic blend include: - *Antibiotic-Associated Diarrhea (AAD)*: Significantly reduces risk with strains like *Lactobacillus acidophilus* and *L. rhamnosus*. (RR 0.44; p < 0.05) - *Constipation*: The SYNBIO® blend shows improvement in symptom relief (weighted mean difference 0.75; p = 0.0008). - *Irritable Bowel Syndrome (IBS)*: Certain strains significantly outperform placebo in symptom improvement, enhancing quality of life. - *Liver Health*: Some evidence suggests improvements in liver enzymes in NAFLD, though more investigation is required. Populations benefitting most include both pediatric and adult patients, particularly those experiencing gastrointestinal imbalances.
How it works
Probiotics function by modulating gut microbiota balance, improving intestinal barrier function, and producing metabolites that influence immune responses. They interact primarily with the gastrointestinal and immune systems, enhancing mucosal immunity and modulating inflammatory pathways. Probiotics can influence tight junction proteins, affecting gut permeability and overall systemic health. The effectiveness of probiotics relies on their ability to survive digestive processes, allowing them to colonize beneficially within the intestines.
Side effects
Probiotics are considered safe for most healthy individuals, though mild gastrointestinal side effects such as bloating, gas, and abdominal discomfort can occur in over 5% of users. Rare adverse effects (<1%) may include bacteremia or fungemia in severely immunocompromised patients, and uncommon effects (1-5%) could encompass allergic reactions or infections. Special consideration should be given to individuals with severe immunodeficiency or those undergoing critical treatments, as probiotics can interact with immunosuppressive medications. Consult healthcare providers prior to use for vulnerable populations, including pregnant women, children, and the elderly.
Dosage
The effective dosage of probiotic bacteria varies by strain and condition, typically ranging from 1 to 10 billion CFU per day. For preventing antibiotic-associated diarrhea, 1-2 billion CFU per day is generally effective. For IBS, higher doses may be necessary. While there is no established maximum safe dosage, doses exceeding 10 billion CFU are less commonly studied. Probiotics can be taken at any time, although taking them with food may enhance their survival through the gastrointestinal tract. Forms such as capsules, powders, and enriched foods should ensure effective delivery to the intestines.
FAQs
How long does it take to see benefits?
Benefits can typically be observed within a few weeks to months of consistent probiotic use.
Are probiotics safe for everyone?
Probiotics are generally safe, but special populations should consult healthcare professionals before starting supplementation.
Can probiotics interact with medications?
Yes, particularly with immunosuppressive drugs, they may alter the efficacy of some medications.
What are the common side effects?
Mild gastrointestinal symptoms such as bloating and gas can occur in some users.
When should I take probiotics?
Probiotics can be taken at any time, but taking them with food may enhance their effectiveness.
Research Sources
- https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2018.00124/full – This systematic review discusses the importance of strain-specific and disease-specific probiotic efficacy, revealing strong evidence for strains like *Lactobacillus rhamnosus* GG in preventing pediatric AAD.
- https://www.mdpi.com/2311-5637/10/10/518 – A meta-analysis demonstrating the SYNBIO® blend's significant efficacy in improving constipation relief and intestinal regularity, showcasing high-quality evidence with statistical relevance.
- https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.844242/full – Network meta-analysis of probiotic strain efficacy for IBS, presenting evidence that certain probiotic blends outperform placebo significantly in alleviating IBS symptoms.
- https://jamanetwork.com/journals/jama/fullarticle/1151505 – Comprehensive analysis highlighting the effect of specific probiotic combinations for various gastrointestinal disorders, with a focus on systematic methodologies and effectiveness.
- https://pubmed.ncbi.nlm.nih.gov/37686889/ – This article reviews the benefits and safety of various probiotic strains, emphasizing their role in gut health and the need for personalization based on individual health conditions.
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