Proprietary Liquid Extract Blend Of
Also known as: East Indian globe thistle, Gorakhmundi, Mangifera indica, Mango, Sphaeranthus indicus
Overview
The proprietary liquid extract blend combines *Sphaeranthus indicus*, a plant native to tropical and subtropical Asia, which is commonly used in dietary supplements, and *Mangifera indica*, known as mango, utilized for its fruit and bark. This blend is formulated to enhance muscle strength, endurance, and overall physical performance, particularly in conjunction with resistance training. The blend is characterized by its ability to activate mTOR pathways, which are critical for muscle hypertrophy and enhancing nitric oxide production in endothelial cells, indicating a potential role in improving physical performance and recovery. Although still emerging, the clinical evidence primarily stems from a limited number of studies evaluating its effectiveness in healthy young adults engaged in regular physical training.
Benefits
Research indicates that supplementation with the *Sphaeranthus indicus* and *Mangifera indica* blend significantly improves muscle strength and endurance. In a clinical trial of 99 recreationally active young men, those taking the higher dose of 850 mg daily demonstrated notably greater gains in muscle strength across various tests when paired with resistance training than the placebo group. No significant impact on hormone levels such as testosterone or cortisol was observed, suggesting that the benefits are primarily related to muscle function rather than hormonal modulation. This data underlines the importance of this blend for physically active individuals looking to enhance performance.
How it works
The blend primarily functions through the activation of the mTOR pathway, which is essential for muscle protein synthesis and facilitating muscle cell growth. It also promotes the expression of muscle-specific transcription factors, including myogenin and myoD, which are vital for muscle growth and regeneration. Furthermore, the enhanced production of nitric oxide improves blood flow and nutrient delivery to muscle tissues during physical activity, thus supporting better exercise performance and recovery.
Side effects
The proprietary extract blend appears to have a favorable safety profile as reported in clinical trials. No significant adverse effects have been identified among participants, with typical safety parameters remaining within expected ranges following the supplementation period. Specifically, no common side effects were reported for more than 5% of participants, nor were there indications of uncommon or rare side effects. There is currently no information on drug interactions or contraindications, although the research population was limited to young, recreationally active men, warranting further investigation into broader demographic safety.
Dosage
The recommended dosage of the extract blend ranges from a minimum of 425 mg to an optimal 850 mg per day, as established in clinical trials. Subjects typically took their dosage every morning over an 8-week period. While no maximum safe dose was specified, the highest dosage used in studies did not lead to any reported negative effects, indicating that 850 mg is a potentially viable upper threshold. The water-soluble formulation utilized may enhance absorption and bioavailability, although details on specific absorption characteristics were not discussed in the literature.
FAQs
How should I take this supplement?
Take the supplement consistently every morning, ideally alongside a resistance training program for optimal benefits.
Is this supplement safe for everyone?
It appears safe for young, recreationally active men, but further research is needed for other demographics, including women and older adults.
When can I expect results?
Users can anticipate improvements in muscle strength and endurance over an 8-week period with consistent use.
Does it affect hormone levels?
Current studies indicate it does not significantly alter serum testosterone or cortisol levels.
What is the optimal dose for best results?
The optimal dose is between 425 mg and 850 mg per day, with higher doses showing greater effectiveness.
Research Sources
- https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1393917/full – This study evaluated the effects of a proprietary blend of Sphaeranthus indicus and Mangifera indica on muscle strength and endurance in male participants over 8 weeks, highlighting significant improvements in muscle performance metrics.
- https://pubmed.ncbi.nlm.nih.gov/36364865/ – Clinical findings reported improvements in muscle strength and positive safety markers following supplementation, reinforcing the blend's efficacy in enhancing physical performance.
- https://jamanetwork.com/journals/jama/fullarticle/1151505 – An overview of various dietary treatments for enhancing athletic performance, placing the extract blend within the context of herbal and botanical supplements backed by emerging evidence.
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