Proprietary Nitric Oxide Blend
Also known as: Nitric Oxide Precursors, NO Boosters, Nitrate Supplements, Beetroot Juice, Citrulline, NO Precursors
Overview
Nitric oxide (NO) precursors are substances that enhance the body's production of nitric oxide, a molecule crucial for vasodilation and improved blood flow. These precursors are often found in dietary supplements aimed at improving exercise performance and cardiovascular health. Natural sources include nitrate-rich vegetables like beetroot and spinach, as well as amino acids such as citrulline. Supplements typically contain a blend of these ingredients to maximize NO production. The increased NO levels promote the relaxation of blood vessels, leading to enhanced oxygen and nutrient delivery to muscles and organs. Research on NO precursors is moderately mature, with numerous studies and meta-analyses supporting their effectiveness in specific contexts. They are available in various forms, including powders, capsules, and liquids, making them accessible for diverse consumer preferences. While generally safe, it's important to adhere to recommended dosages and be aware of potential side effects.
Benefits
Nitric oxide (NO) precursors primarily enhance exercise performance and cardiovascular health. Studies show that nitrate supplementation improves endurance exercise performance, particularly in recreationally active individuals. A systematic review and meta-analysis demonstrated a significant ergogenic effect of nitrate supplementation in young, healthy men across different exercises. NO precursors also help reduce blood pressure and improve vascular function, contributing to better cardiovascular health. Some evidence suggests benefits in strength training, though this is less consistent. The benefits are most pronounced in young, healthy individuals engaging in aerobic exercise, with moderate effect sizes (Cohen's d around 0.5) observed for exercise performance improvements. These benefits typically manifest within a few hours of supplementation and can last for several hours.
How it works
Nitric oxide (NO) precursors increase nitric oxide production in the body, leading to vasodilation. This process involves the relaxation of smooth muscle cells in blood vessels, enhancing blood flow. The primary biological pathway involves the conversion of nitrates from sources like beetroot into nitrite, which is then converted to NO. Citrulline, another common precursor, is converted to arginine, a direct precursor to NO production via the enzyme endothelial nitric oxide synthase (eNOS). The increased NO interacts primarily with the cardiovascular system, improving blood flow and reducing blood pressure. This enhanced blood flow supports better oxygen and nutrient delivery to muscles and other tissues, improving exercise performance and overall cardiovascular function.
Side effects
Nitric oxide (NO) precursors are generally considered safe when used appropriately, but they can cause side effects in some individuals. Common side effects (occurring in more than 5% of users) include gastrointestinal upset, such as diarrhea or stomach discomfort. Uncommon side effects (1-5%) may include headaches or dizziness. Rare side effects (less than 1%) involve allergic reactions. These supplements may interact with blood thinners or medications for hypertension, potentially altering their effects. Individuals with certain medical conditions, such as hypotension, should consult a healthcare provider before use. Pregnant or breastfeeding women should also seek medical advice before using NO precursors. It is important to adhere to recommended dosages to minimize the risk of adverse effects.
Dosage
The minimum effective dose of citrulline is typically around 500-1000 mg, while optimal dosage ranges are between 1000-2000 mg. For nitrates, beetroot juice is often used, with about 500 ml providing an effective dose. While a maximum safe dose is not definitively established, high doses may increase the risk of side effects. It is best to take NO precursors 1-2 hours before exercise to maximize their benefits. Citrulline malate is often preferred due to its enhanced bioavailability. Absorption can be influenced by stomach pH and the presence of other nutrients. Adequate hydration is recommended to support optimal effects. Always start with a lower dose to assess tolerance and gradually increase as needed.
FAQs
When is the best time to take nitric oxide precursors?
For optimal benefits, take nitric oxide precursors 1-2 hours before exercise. This timing allows for peak nitric oxide production during physical activity, enhancing blood flow and performance.
What are the expected benefits of taking these supplements?
Users can expect improved exercise performance, including increased endurance and reduced fatigue. Additionally, nitric oxide precursors may offer cardiovascular benefits, such as reduced blood pressure.
Are nitric oxide precursors safe to use?
Generally, nitric oxide precursors are safe for most individuals. However, it's important to consult a healthcare provider if you have underlying medical conditions or are taking medications, especially blood thinners.
Can nitric oxide precursors replace regular exercise?
No, nitric oxide precursors are not a substitute for regular exercise or a healthy diet. They are best used as a supplement to enhance the benefits of a healthy lifestyle.
What is the difference between L-arginine and L-citrulline?
L-citrulline is a more effective nitric oxide booster than L-arginine. L-citrulline converts to L-arginine in the kidneys, increasing L-arginine levels while avoiding breakdown in the liver.
Research Sources
- https://pmc.ncbi.nlm.nih.gov/articles/PMC7494956/ – This systematic review and meta-analysis demonstrated a significant ergogenic effect of nitrate supplementation in young, healthy men across different exercises. The study highlights that nitrate supplementation can improve exercise performance, making it a valuable tool for athletes and recreationally active individuals.
- https://pubmed.ncbi.nlm.nih.gov/30895562/ – This study found that acute citrulline supplementation enhances high-intensity exercise performance by increasing nitric oxide production. The research suggests that citrulline can be an effective supplement for improving performance in activities requiring high-intensity effort.
- https://www.mdpi.com/2072-6643/15/3/660 – This review highlights the potential benefits of NO precursors for strength training, though evidence is less consistent compared to endurance activities. The study indicates that while NO precursors may offer some advantages for strength training, more research is needed to confirm these effects.
- https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/effects-of-beetroot-and-nitrate-supplementation-on-body-composition-a-gradeassessed-systematic-review-and-metaanalysis/949832E60B3818D6D849353FC0B117FE – This systematic review and meta-analysis assessed the effects of beetroot and nitrate supplementation on body composition. The findings contribute to the understanding of how these supplements can influence body composition, although the primary focus is not on exercise performance.
- https://www.mdpi.com/2227-9059/11/7/1859 – This review provides an overview of the effects of nitrate supplementation on exercise performance and vascular function. The study consolidates existing knowledge on the benefits of nitrate supplementation, supporting its use for enhancing physical performance and cardiovascular health.
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