Proprietary Tamaflex Blend
Also known as: NXT15906F6, proprietary blend of tamarind seed and turmeric rhizome extracts, Tamarindus indica and Curcuma longa extracts, TamaFlex
Overview
TamaFlex, also known as NXT15906F6, is a proprietary botanical blend formulated from standardized aqueous and ethanolic extracts of Tamarindus indica (tamarind) seeds and Curcuma longa (turmeric) rhizomes. Both botanicals have a long history of use in traditional Asian medicine and cuisine. This blend is primarily utilized as a joint health supplement, specifically designed to alleviate joint pain, enhance joint function, and support overall musculoskeletal health, particularly in individuals experiencing mild to moderate knee osteoarthritis (KOA). Key characteristics include a minimum of 65% proanthocyanidins from tamarind and 3% total curcuminoids from turmeric, targeting inflammation and cartilage degradation. Research supporting TamaFlex includes randomized, double-blind, placebo-controlled clinical trials, indicating a moderate level of research maturity and robust evidence for its efficacy.
Benefits
TamaFlex offers several evidence-based benefits for joint health. The primary effect is a significant reduction in knee pain and joint stiffness, as measured by WOMAC scores, with improvements observed as early as 5 days into supplementation and sustained over 30 days. It also leads to improved musculoskeletal function and joint flexibility. Furthermore, TamaFlex has been shown to reduce inflammatory biomarkers such as high-sensitivity C-reactive protein (hs-CRP) and the cartilage degradation marker urinary C-terminal cross-linked telopeptide of type II collagen (uCTX-II). Secondary benefits include enhanced aerobic capacity and lower body strength in individuals with knee osteoarthritis. These benefits are particularly noted in adults aged 40–70 years with mild to moderate knee osteoarthritis and a BMI between 20–29 kg/m². Clinical trials have demonstrated statistically significant improvements (p < 0.05) in WOMAC total scores and biomarker levels compared to placebo, with a notable early onset of benefit.
How it works
TamaFlex exerts its beneficial effects primarily through anti-inflammatory mechanisms. The bioactive compounds, specifically proanthocyanidins from tamarind and curcuminoids from turmeric, are believed to reduce systemic inflammation and inhibit cartilage degradation. This blend interacts with the musculoskeletal system by modulating inflammatory pathways, leading to a reduction in inflammatory cytokines and markers of cartilage breakdown. This action ultimately contributes to improved joint comfort and function. Known molecular targets include the inhibition of inflammatory pathways, evidenced by a reduction in hs-CRP, and the modulation of cartilage degradation, indicated by decreased uCTX-II. While curcuminoids are known for their limited bioavailability, the proprietary formulation and standardization of extracts are presumed to optimize efficacy, though specific pharmacokinetic data for this blend are not detailed.
Side effects
TamaFlex is generally considered safe based on toxicological evaluations in animal models and human clinical trials. No significant adverse events have been reported in the available studies, and common, uncommon, or rare side effects (e.g., >5%, 1-5%, or <1% frequency, respectively) have not been documented. Regarding drug interactions, no specific interactions for TamaFlex have been reported. However, due to the presence of turmeric, caution is advised as turmeric is known to potentially interact with anticoagulants (blood thinners) and other medications. While no explicit contraindications are reported for the blend itself, standard precautions applicable to individual tamarind and turmeric extracts should be considered. Safety in specific populations such as pregnant or lactating women, children, or individuals with severe osteoarthritis has not been established, and therefore, use in these groups is not recommended without medical supervision.
Dosage
The minimum effective dose for TamaFlex (NXT15906F6) is 250 mg daily. This optimal dosage range was established in clinical trials, where 250 mg daily demonstrated significant efficacy. Comparative studies indicated that this dose provided better early efficacy than other botanical blends at higher doses (e.g., 1000 mg). The maximum safe dose has not been explicitly defined, but safety studies suggest good tolerability at the tested doses. For optimal results, TamaFlex should be taken once daily, preferably after breakfast. It is typically available in standardized aqueous and ethanolic extract forms, combined in a capsule or tablet. While no specific absorption enhancers are reported for this blend, it's generally known that turmeric's bioavailability can be limited without adjuncts like piperine, though this blend does not specify their inclusion. No specific cofactors are required for its efficacy.
FAQs
Is TamaFlex safe for long-term use?
Current data support safety for at least 30 days of use. Long-term safety beyond this period requires further dedicated study to be fully established.
How quickly does TamaFlex work?
Improvements in joint pain and function have been observed relatively quickly, with noticeable benefits reported within just 5 days of consistent supplementation.
Can TamaFlex replace NSAIDs?
While TamaFlex can reduce inflammation and pain, it is not a direct substitute for NSAIDs. Always consult a healthcare provider before making changes to your medication regimen.
Are there any known allergies?
Individuals with known allergies to either tamarind or turmeric, the primary components of TamaFlex, should avoid using this supplement to prevent adverse reactions.
Does it help severe osteoarthritis?
The current evidence for TamaFlex's efficacy is limited to individuals with mild to moderate knee osteoarthritis. Its benefits for severe cases have not been studied.
Research Sources
- https://pmc.ncbi.nlm.nih.gov/articles/PMC10284097/ – This randomized, double-blind, placebo-controlled clinical trial with 150 adults (40–70 years) with mild to moderate knee osteoarthritis found that 250 mg of TamaFlex significantly reduced WOMAC scores, hs-CRP, and uCTX-II compared to placebo over 30 days. Improvements in joint pain and function were observed within 5 days, indicating high-quality evidence for its efficacy.
- https://www.nutritionaloutlook.com/view/proprietary-blend-of-tamarind-seed-and-turmeric-rhizome-extracts-reduced-knee-pain-and-improved-joint-function-in-recent-study – This article summarizes the findings of the primary RCT, confirming that the proprietary blend significantly reduced knee pain and improved joint function. It highlights the early efficacy of TamaFlex compared to other botanical blends, supporting the primary study's conclusions.
- https://journals.sagepub.com/doi/10.1177/2397847317749240 – This preclinical safety evaluation conducted in animal models found no toxicity associated with the TamaFlex blend. The study provides supportive evidence for the human safety profile of the supplement, indicating good tolerability at tested doses.
- https://www.naturalhealthresearch.org/a-proprietary-blend-of-tamarind-and-curcumin-improves-musculoskeletal-function-in-adults-with-osteoarthritis/ – This source provides an overview of how the proprietary blend of tamarind and curcumin improves musculoskeletal function in adults with osteoarthritis. It reiterates the benefits observed in clinical trials, emphasizing the blend's positive impact on joint health.
- https://www.nutraingredients-usa.com/Article/2023/07/13/clinical-trial-supports-tamaflex-joint-health-benefits/ – This article reports on the clinical trial supporting TamaFlex's joint health benefits. It discusses the positive outcomes in reducing pain and improving function, reinforcing the scientific backing for the supplement's claims.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC9514497/ – This source, while not directly about TamaFlex, likely provides background information on the individual components or related joint health research. It contributes to the broader understanding of botanical interventions for osteoarthritis.
- https://www.tandfonline.com/doi/abs/10.1080/27697061.2023.2209880 – This abstract likely details further research or a review related to the efficacy of botanical extracts in joint health. It could offer additional context or supporting evidence for the mechanisms of action or benefits of ingredients found in TamaFlex.
Supplements Containing Proprietary Tamaflex Blend
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