Protease Am
Also known as: Protease, Proteolytic enzyme, Papain, Bromelain
Overview
Proteases are enzymes that catalyze the breakdown of proteins into smaller peptides or amino acids. Naturally occurring in the human body and found in various food sources such as papaya (papain) and pineapple (bromelain), they play a vital role in protein digestion and nutrient absorption. Their primary application lies in promoting better digestion, particularly in individuals with digestive disorders or high-protein diets. Proteases are classified based on their source, including microbial, plant, or animal origins. While there is strong evidence supporting their digestive benefits, additional research is necessary to fully understand their effects on broader health implications. The general consensus regarding protease research is moderate maturity, with findings primarily indicating their beneficial role in digestion.
Benefits
Proteases primarily enhance protein digestion and absorption, which can improve nutrient availability in the body. Key studies indicate a significant increase in amino acid concentrations when microbial proteases are supplemented, particularly post-meal. Secondary benefits may include potential anti-inflammatory properties and improved gut health; however, the evidence supporting these claims is less robust. The target populations for these benefits include individuals with compromised digestive systems or those on high-protein diets. Studies generally demonstrate clinical significance in enhancing amino acid availability within hours of ingestion. Overall, the evidence is moderate, emphasizing the importance of using proteases as digestive aids in appropriate contexts.
How it works
Proteases function by hydrolyzing peptide bonds in proteins, resulting in the formation of smaller peptides and free amino acids, which are more readily absorbed in the gastrointestinal tract. They primarily interact with the digestive system, enhancing nutrient breakdown. Importantly, while proteases assist in digesting proteins, they are not absorbed themselves, but rather facilitate the absorption of amino acids released during digestion. They may also influence broader nutrient availability and interact with components of the immune system.
Side effects
Proteases are generally safe when utilized as directed, with few adverse effects noted. Common side effects may include gastrointestinal discomfort such as bloating and gas, occurring in more than 5% of users. Less frequently (1-5%), some individuals may experience allergic reactions to specific protease sources. Severe allergic reactions are rare (<1%). There are known drug interactions with antacids and other medications that alter gastric pH, which can impact the enzyme's activity. Moreover, individuals with allergies to specific protease sources should avoid these supplements. Precaution is advised for pregnant and breastfeeding women due to the limited studies on safety in these populations.
Dosage
The optimal dosage of protease varies according to its type and source, typically ranging from 10 to 50 mg per serving. It is generally recommended to take these supplements with meals to aid in the digestion of protein. While no definitive maximum safe dose is established, users should adhere to prescribed guidelines. Proteases are best consumed with protein-rich meals to enhance their effectiveness. Formulations may include capsules, tablets, or blends of digestive enzymes, with absorption influenced by stomach acidity and the presence of other digestive aids.
FAQs
How should proteases be taken?
Proteases are best taken with meals to enhance protein digestion and absorption.
Are there any side effects?
While generally safe, some may experience gastrointestinal upset, such as bloating or gas.
What results can I expect from using protease?
You may experience improved protein digestion and potentially reduced gastrointestinal discomfort.
Is protease a substitute for medical treatment?
No, protease supplements are not a substitute for prescribed treatments for digestive disorders.
Can everyone take proteases safely?
Most individuals can take proteases safely, but those with allergies to specific sources should avoid them.
Research Sources
- https://pmc.ncbi.nlm.nih.gov/articles/PMC7232218/ – This study demonstrates that microbial protease supplementation can significantly increase postprandial plasma amino acid concentrations compared to a placebo, providing evidence for its benefits in protein digestion.
- https://research.manchester.ac.uk/portal/files/54574960/FULL_TEXT.PDF – This meta-analysis supports the use of proteases for improving protein digestion overall, highlighting the need for more studies focusing on specific protease effects due to variability in research quality.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC11130700/ – This systematic review encapsulates evidence regarding proteases and their potential benefits for enhancing protein digestion and absorption, emphasizing the need for quality research in the field.
- https://nopren.ucsf.edu/sites/g/files/tkssra5936/f/wysiwyg/ONLY_newarticles_11Feb2022_Food.xlsx – The source summarizes recent articles on protease studies, reinforcing findings related to their role in digestive health but highlights the limitations associated with the data.
- https://apm.amegroups.org/article/view/72220/html – This article reviews the effects of various digestive enzymes, including proteases, outlining their importance in digestive health, particularly for individuals with protein digestion issues.
Supplements Containing Protease Am
Amplified Wheybolic Extreme 60 Casein Vanilla
GNC Pro Performance AMP
Amplified Wheybolic Extreme 60 Original Vanilla
GNC Pro Performance AMP
Heal-n-Soothe Systemic Enzyme Formula
Living Well Nutraceuticals
Biofilm Defense
Kirkman
GNC Pro Performance® AMP Gold Series 100% Whey Protein Advanced
GNC Pro Performance® AMP
Heal-n-Soothe® Systemic Enzyme Formula
LIVINGWELL® NUTRACEUTICALS
Heal-n-Soothe®
LIVINGWELL®
