Protectin Proprietary Blend
Also known as: Protectin Proprietary Blend, MyoTOR®, RipFACTOR®, Sphaeranthus indicus flower head extract, Mangifera indica stem bark extract, LI12542F6
Overview
LI12542F6, also marketed as MyoTOR® or RipFACTOR®, is a proprietary herbal blend primarily composed of extracts from Sphaeranthus indicus flower head and Mangifera indica (mango) stem bark. Both botanicals have a history of use in Ayurvedic medicine. This blend is positioned as a dietary supplement aimed at enhancing muscle strength, size, endurance, and lean body mass in healthy adults engaged in resistance training. Research suggests it may achieve these effects by modulating key biomarkers related to muscle metabolism, specifically by increasing free testosterone and decreasing cortisol levels. While promising, the current evidence base is limited to a single randomized controlled trial.
Benefits
The primary benefit of LI12542F6, when combined with resistance training, is a significant increase in muscle strength and size, as well as improved muscle endurance and lean body mass in healthy young men. A 56-day randomized controlled trial observed these improvements. Additionally, the blend led to a statistically significant increase in free testosterone (p=0.0105) and a decrease in cortisol levels, which are hormonal changes conducive to muscle protein synthesis and growth. These benefits were observed specifically in healthy young male adults undergoing resistance training. The supplement was well-tolerated with no reported adverse effects in the study.
How it works
LI12542F6 is believed to exert its effects primarily through the modulation of the endocrine system, influencing hormones critical for muscle growth and recovery. Specifically, it has been shown to increase levels of free testosterone, an anabolic hormone that promotes muscle protein synthesis, and decrease cortisol, a catabolic hormone that can break down muscle tissue. This dual action creates a more favorable hormonal environment for muscle development. While the exact molecular targets are not fully elucidated, the blend's impact on these key hormones suggests an influence on pathways regulating muscle metabolism and growth, potentially including those related to mTOR signaling, though this requires further investigation.
Side effects
Based on the available research, LI12542F6 appears to be well-tolerated. A 56-day randomized controlled trial involving healthy young men reported no adverse events or side effects. There is currently no data available regarding common, uncommon, or rare side effects. Furthermore, information on potential drug interactions or contraindications is not specified in the existing literature. It is important to note that safety data is limited to the specific population and duration studied (healthy young men over 8 weeks), and there is no information regarding its safety for women, elderly individuals, or those with pre-existing medical conditions.
Dosage
The specific dosage of LI12542F6 used in the primary research study involved supplementation concurrent with resistance training over a 56-day period. However, the exact milligram amounts of the individual ingredients within the proprietary blend were not explicitly provided. Therefore, a minimum effective dose, optimal dosage range, or maximum safe dose has not been definitively established. The supplement is typically consumed orally, likely in capsule or tablet form. There are no reported timing considerations beyond consistent daily intake during the resistance training period, nor are there any known required cofactors or specific absorption factors described in the available research.
FAQs
Is Protectin Proprietary Blend safe?
A 56-day randomized controlled trial found it to be well-tolerated with no reported adverse effects in healthy young men. However, data for other populations or longer durations is not available.
How soon can benefits be expected?
Significant improvements in muscle strength, size, and hormonal changes were observed after 8 weeks of consistent supplementation combined with resistance training.
Is it effective without exercise?
The primary study combined supplementation with resistance training, so there is no data to suggest its effectiveness without an exercise regimen.
Are there any known drug interactions?
Currently, there is no available data or research on potential drug interactions with LI12542F6 or Protectin Proprietary Blend.
Is it suitable for women or older adults?
The existing research focused exclusively on healthy young men, so there is no evidence regarding its suitability or effects in women or older adults.
Research Sources
- https://pmc.ncbi.nlm.nih.gov/articles/PMC9899043/ – This randomized, double-blind, placebo-controlled trial investigated the effects of LI12542F6 (MyoTOR®) on muscle strength, size, and hormonal profiles in 40 healthy young men undergoing resistance training over 56 days. The study found significant increases in muscle strength, size, and endurance, alongside increased free testosterone and decreased cortisol levels in the supplement group, with no reported adverse effects. While manufacturer-funded, the authors declared no conflicts of interest, indicating a moderate quality study with promising results that warrant further independent replication.
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