Purslane Tops Extract
Also known as: Purslane tops extract, Common purslane extract, Purslane extract, Portulaca oleracea L. extract
Overview
Purslane tops extract is derived from the aerial parts of *Portulaca oleracea*, a succulent plant with a long history of traditional medicinal use. It is recognized for its anti-inflammatory, antioxidant, lipid-lowering, and glycemic control properties. The extract is rich in bioactive compounds, including omega-3 fatty acids, flavonoids, and alkaloids, which contribute to its therapeutic effects. Research on purslane extract is moderately developed, with several randomized controlled trials (RCTs) and meta-analyses supporting its benefits, particularly in cardiovascular health and metabolic regulation. While promising, further large-scale clinical trials are needed to solidify definitive conclusions regarding its long-term efficacy and safety.
Benefits
Purslane tops extract offers several evidence-based benefits. A meta-analysis of 13 RCTs demonstrated significant improvements in cardiovascular health, showing reductions in serum triglycerides (by ~16.7 mg/dL), total cholesterol (by ~10 mg/dL), and C-reactive protein (CRP) (by 1.22 mg/L), alongside an increase in HDL cholesterol (by 4.1 mg/dL). This indicates a positive impact on lipid profiles and inflammation. Animal studies have shown anti-inflammatory effects, with the extract suppressing bowel inflammation by inhibiting the TLR4/NF-κB signaling pathway and reducing pro-inflammatory cytokines like TNF-α and IL-6. Furthermore, meta-analyses suggest purslane can improve oxidative stress markers and glycemic parameters, making it a potential aid in managing diabetes and metabolic syndrome. Clinical evidence also points to a transient bronchodilatory effect in asthmatic patients, comparable in onset to theophylline but with a shorter duration (60-120 minutes).
How it works
The anti-inflammatory effects of purslane extract are primarily mediated through the inhibition of the toll-like receptor 4 (TLR4) and nuclear factor kappa B (NF-κB) signaling pathway, which leads to a downregulation of pro-inflammatory cytokines. Its antioxidant properties stem from the presence of flavonoids and other phytochemicals that scavenge free radicals, thereby reducing oxidative stress. The lipid-lowering effects are thought to involve the modulation of enzymes involved in lipid metabolism and an enhancement of HDL cholesterol synthesis. While the exact molecular targets for its bronchodilatory effect are not fully elucidated, it is believed to involve the relaxation of smooth muscles in the airways.
Side effects
Purslane consumption, including its extract, is generally considered safe, with clinical trials reporting no serious adverse effects at doses up to 30 g/day. Common side effects are rare and not extensively documented in the literature. Currently, no significant drug interactions or contraindications have been firmly established. However, due to limited research, specific caution is advised for special populations such as pregnant women, breastfeeding mothers, and individuals on immunosuppressants. It is always recommended to consult a healthcare professional before starting any new supplement, especially if you have pre-existing health conditions or are taking other medications, to ensure safety and avoid potential unforeseen interactions.
Dosage
Optimal dosing for purslane extract varies, but clinical studies have utilized up to 30 g/day of whole purslane consumption or equivalent extract doses (e.g., 200 mg/kg/day in animal models). The timing and formulation can differ, with oral administration being the standard method. The bioavailability of the active compounds may be influenced by the specific extraction method and the final product formulation. There are no specific cofactors identified as being required for its absorption. While 30 g/day appears to be a safe upper limit based on current research, it is important to follow product-specific recommendations or consult a healthcare professional for personalized dosage advice, especially for targeted health conditions.
FAQs
Is purslane extract effective for cardiovascular health?
Yes, meta-analyses indicate that purslane extract can significantly improve lipid profiles by reducing triglycerides and total cholesterol, and increasing HDL cholesterol, while also lowering inflammation markers.
Can purslane help with diabetes?
Preliminary meta-analytic data suggest that purslane extract may offer benefits for glycemic control and can help improve markers of oxidative stress, which are relevant for diabetes management.
Is purslane extract safe for long-term use?
Current research supports the safety of purslane consumption up to 30 g/day, but long-term studies specifically on the extract's safety profile are still limited. Consultation with a healthcare provider is recommended for extended use.
How quickly do the effects of purslane extract appear?
Anti-inflammatory and lipid-modulating effects have been observed over weeks to months of consistent use. Bronchodilatory effects, if present, are typically acute but transient, lasting 60-120 minutes.
Research Sources
- https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1474989/full – This animal study demonstrated that purslane extract effectively reduced bowel inflammation in obese mice by inhibiting the TLR4/NF-κB signaling pathway, leading to a decrease in pro-inflammatory cytokines TNF-α and IL-6. The findings provide mechanistic insights into the anti-inflammatory properties of purslane.
- https://pubmed.ncbi.nlm.nih.gov/37970383/ – This meta-analysis of 13 randomized controlled trials (RCTs) found that purslane consumption significantly improved lipid profiles by reducing serum triglycerides, total cholesterol, and C-reactive protein, while increasing HDL cholesterol. It highlights purslane's potential for cardiovascular health benefits.
- https://www.scholarsresearchlibrary.com/articles/healing-properties-of-purslane-a-systematic-review-study.pdf – This clinical trial investigated the bronchodilatory effects of purslane in asthmatic patients, observing a transient but significant effect comparable in onset to theophylline. The study provides preliminary clinical data on purslane's potential role in respiratory conditions, though with a shorter duration of action.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC10261734/ – This meta-analysis suggests that purslane can improve glycemic control and oxidative stress markers. While promising, the authors note that the quality and number of included RCTs were variable, indicating a need for more robust research to confirm these benefits definitively.
