Pygeum Africanum Bark Powder
Also known as: Pygeum africanum, African plum tree, Pygeum
Overview
Pygeum africanum, also known as the African plum tree, is a tree native to Africa. Its bark extract is used as a herbal supplement, primarily for alleviating symptoms of benign prostatic hyperplasia (BPH). The bark contains beneficial compounds like beta-sitosterol. It has been traditionally used to treat urinary problems associated with BPH, such as nocturia, urinary frequency, and urinary flow issues. Research on Pygeum africanum is considered moderate, with several randomized controlled trials and systematic reviews available, though studies are often limited by short durations and variability in design. The supplement is generally considered safe, with mild side effects similar to placebo. It is available in forms like capsules or tablets.
Benefits
Pygeum africanum is primarily used to alleviate symptoms of BPH. Studies indicate that men using Pygeum africanum are more than twice as likely to report symptom improvement (RR=2.1, 95% CI: 1.4 to 3.1). Specifically, nocturia is reduced by 19%, residual urine volume by 24%, and peak urine flow increased by 23%. These benefits are typically observed within 30 to 122 days of use. Additionally, its anti-inflammatory effects may contribute to its benefits in BPH, potentially reducing inflammation in the prostate. The effect size for symptom improvement is moderate (-0.8 SD).
How it works
Pygeum africanum is believed to work by inhibiting pro-inflammatory prostaglandins and leukotrienes in the prostate, which may reduce inflammation associated with BPH. Sterols like beta-sitosterol may interact with androgen receptors or influence prostaglandin synthesis. By affecting these pathways, Pygeum africanum improves urinary flow and reduces BPH symptoms. The exact mechanisms of absorption and bioavailability are not well-defined, but its effects are primarily observed in the urinary system.
Side effects
Pygeum africanum is generally considered safe, with mild side effects similar to placebo. Common side effects are not well-documented, but they are typically mild. Uncommon and rare side effects are also not well-documented in available literature. There are no significant drug interactions documented. While there are no specific contraindications, caution is advised in patients with prostate cancer or other serious conditions. Use in pregnant or breastfeeding women is not well-studied, so caution is advised. Long-term effects are not well-studied, so it is important to consult with a healthcare provider before starting Pygeum africanum.
Dosage
The typical dosage of Pygeum africanum is 50-100 mg per day, often using standardized extracts. There are no specific timing recommendations for its use. Capsules or tablets are common forms. The maximum safe dose is not well-defined, but doses above 100 mg are less commonly studied. There are no documented required cofactors. It is important to consult a healthcare provider before starting Pygeum africanum, especially if you have other health conditions.
FAQs
How quickly can I expect to see results?
Improvement in BPH symptoms may be noticeable within a few weeks of consistent use. However, individual results may vary.
Is Pygeum africanum a cure for BPH?
No, Pygeum africanum is not a cure for BPH, but it may help alleviate symptoms such as nocturia and urinary frequency.
Are there any safety concerns I should be aware of?
Pygeum africanum is generally safe, but long-term effects are not well-studied. Consult a healthcare provider before use, especially if you have other health conditions.
When is the best time to take Pygeum africanum?
There are no specific timing recommendations. It can be taken at any time of day, but consistency is key for optimal results.
Should I consult a healthcare provider before starting Pygeum africanum?
Yes, it is important to consult a healthcare provider before starting Pygeum africanum, especially if you have other health conditions or are taking other medications.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/11099686/ – This systematic review and meta-analysis by Ishani et al. (2000) included 18 RCTs involving 1,562 men and found that Pygeum africanum significantly improved urologic symptoms and flow measures compared to placebo. The authors noted limitations due to short study durations and variability in study design, highlighting the need for more rigorous research.
- https://pubmed.ncbi.nlm.nih.gov/11869585/ – A Cochrane Review (2002) assessed the evidence for Pygeum africanum in treating BPH and highlighted the need for more rigorous studies comparing it to standard BPH treatments. The review indicated that while Pygeum africanum showed promise, the evidence was not strong enough to support its use over conventional therapies.
- https://www.mdpi.com/1422-0067/25/15/8298 – A 2024 study demonstrated the anti-inflammatory potential of Pygeum africanum bark extract by showing a reduction in cytokine release in human cells. This finding supports the potential use of Pygeum africanum in managing BPH and other inflammatory conditions, suggesting a mechanism through which it may alleviate BPH symptoms.
- https://pubmed.ncbi.nlm.nih.gov/39125867/ – This study investigates the effects of Pygeum africanum on benign prostatic hyperplasia. The research provides insights into the clinical efficacy and potential mechanisms of action of Pygeum africanum in managing BPH symptoms.
- https://silvershell.com.tr/wp-content/uploads/2022/08/Ref.-39.-Ishani-et-al-2000.pdf – This is a duplicate citation of the Ishani et al. (2000) meta-analysis. The study found that Pygeum africanum significantly improved urologic symptoms and flow measures compared to placebo in men with BPH, but noted limitations in the included studies.