Quisqualis indica extract
Also known as: Quisqualis indica L., Rangoon Creeper, Chinese Honeysuckle, Quisqualis indica
Overview
Quisqualis indica, commonly known as Rangoon Creeper or Chinese Honeysuckle, is a plant native to tropical Asia. It has been traditionally used in folk medicine for its potential health benefits. The plant is characterized by its bioactive compounds, including flavonoids and phenolic acids, which contribute to its antioxidant and anti-inflammatory properties. Emerging research suggests that Quisqualis indica extract may have therapeutic effects, particularly for lower urinary tract symptoms (LUTS) and as an antioxidant. It is available primarily as an herbal extract. While research is growing, most studies are small-scale, and more comprehensive clinical trials are needed to fully understand its benefits and safety profile. The quality of available evidence is limited, necessitating further systematic reviews and meta-analyses to validate its therapeutic potential.
Benefits
Quisqualis indica extract has shown potential benefits, particularly for men with lower urinary tract symptoms (LUTS). A study indicated that daily doses of 1,000 mg and 2,000 mg improved LUTS symptoms over 12 weeks. Additionally, in vitro studies have demonstrated its antioxidant activity, showing high scavenging activity against free radicals. These antioxidant properties suggest potential benefits in reducing oxidative stress. However, the effect sizes and clinical significance of these benefits require further investigation through larger, well-designed clinical trials. The current evidence base is limited, and more research is needed to confirm these benefits and determine the optimal conditions for their application.
How it works
Quisqualis indica is believed to exert its effects primarily through antioxidant pathways, which may influence inflammatory processes. The exact mechanism of action is not fully understood, but it likely involves the interaction of its bioactive compounds with various body systems, particularly the urinary and reproductive systems, given its traditional use for LUTS. At the molecular level, it is thought to target antioxidant and anti-inflammatory pathways. However, the absorption and bioavailability of Quisqualis indica extracts are not extensively studied, and may vary based on extraction methods and individual metabolism. Further research is needed to elucidate the precise mechanisms and pathways involved.
Side effects
Quisqualis indica extract is generally considered safe in short-term studies, but comprehensive long-term safety data are limited. Common side effects are not well-documented, but it is reasonable to expect similar effects to other herbal extracts. Potential drug interactions, particularly with medications affecting the urinary or reproductive systems, are not well-studied, and caution is advised. There are no established contraindications, but caution is recommended for pregnant or breastfeeding women due to a lack of safety data in these populations. Limited data are available on the use of Quisqualis indica in children or individuals with severe health conditions. It is essential to consult with a healthcare provider before using Quisqualis indica, especially if taking other medications or having pre-existing health conditions.
Dosage
Based on available studies, the optimal dosage range for Quisqualis indica extract is between 1,000 mg and 2,000 mg daily, particularly for individuals with LUTS. The minimum effective dose has not been definitively established. The maximum safe dose is also not well-defined, and higher doses should be approached with caution. There are no specific timing recommendations available, but consistent daily use may be beneficial. Extracts are the most common form, but bioavailability may vary depending on the extraction method and individual metabolism. No specific cofactors are required for its use. Further research is needed to refine dosage guidelines and establish safety thresholds.
FAQs
Is Quisqualis indica extract safe?
It is generally considered safe for short-term use, but long-term safety data are limited. Consult a healthcare provider before use, especially if you have pre-existing conditions or are taking other medications.
How should I take Quisqualis indica extract?
There are no specific timing recommendations, but consistent daily use may be beneficial. Follow the dosage guidelines of 1,000 mg to 2,000 mg daily, based on available studies, unless otherwise directed by a healthcare provider.
What are the expected benefits of Quisqualis indica extract?
Potential benefits include improvement in LUTS symptoms and antioxidant effects. However, individual results may vary, and it should not be considered a substitute for medical treatment.
Are there any drug interactions?
Potential interactions with medications affecting the urinary or reproductive systems are possible, though not well-studied. Consult with a healthcare provider to discuss potential interactions.
Research Sources
- https://pmc.ncbi.nlm.nih.gov/articles/PMC9834572/ – This randomized, double-blind, placebo-controlled trial (n=135) evaluated the efficacy of Quisqualis indica extract (1,000 mg and 2,000 mg daily) for men with moderate LUTS. The study found therapeutic effects and good tolerability over 12 weeks, suggesting it may be a beneficial treatment for LUTS.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC9532493/ – A toxicity and genotoxicity study of a standardized Quisqualis indica extract found no significant adverse effects. This suggests that Quisqualis indica extract is safe for use in repeated doses, supporting its potential as a therapeutic agent.
- https://ijppr.humanjournals.com/wp-content/uploads/2021/09/2.Pooja-Jamwal-Amit-Chaudhary-Kalpana-Thakur-Hans-Raj-Kapil-Kumar-Verma.pdf – This in vitro study demonstrated high antioxidant activity of Quisqualis indica extracts. The findings highlight the potential health benefits of Quisqualis indica due to its ability to scavenge free radicals, suggesting its use in managing oxidative stress-related conditions.
- https://bbrc.in/evaluation-of-anti-hyperglycaemic-potential-of-the-ethanolic-leaf-extract-of-quisqualis-indica/ – This study evaluates the anti-hyperglycaemic potential of the ethanolic leaf extract of Quisqualis indica. The research suggests that the extract may have properties that help in managing blood sugar levels, indicating a potential role in diabetes management.
- https://jchr.org/index.php/JCHR/article/download/1778/1498/3813 – This article focuses on the phytochemistry and pharmacological activities of Quisqualis indica. It provides an overview of the various chemical compounds found in the plant and their potential therapeutic applications, supporting the traditional uses of Quisqualis indica in folk medicine.
