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Rauwolfia Vomitoria Root Extract

Also known as: Rauwolfia vomitoria, African Snake Root, Indian Snake Root

Overview

Rauwolfia vomitoria, commonly known as African Snake Root, is a plant native to tropical Africa. Its root bark is valued for its bioactive alkaloids, including reserpine, which have been traditionally used for medicinal purposes. The extract is primarily recognized for its historical use in treating hypertension and other cardiovascular conditions. Modern research is exploring its potential antitumor properties, particularly in pancreatic cancer. The plant's alkaloids are believed to interact with neurotransmitter systems, influencing blood pressure and tumor growth. While traditional use has a long history, contemporary clinical research is still emerging, necessitating more rigorous trials to confirm efficacy and safety. Rauwolfia vomitoria is typically available as a root bark extract.

Benefits

Rauwolfia vomitoria extract demonstrates potential antitumor effects, particularly in inhibiting pancreatic cancer cell proliferation, with IC50 values ranging from 83 to 283 µg/mL in in vitro studies. Research indicates it may synergize with gemcitabine to enhance cytotoxicity against pancreatic cancer cells. Furthermore, animal studies suggest that the extract, when combined with vitamin E, may improve hematological indices. Emerging evidence also points to benefits for patients with pancreatic cancer by inhibiting cancer stem cells. However, the clinical significance and effect sizes require further investigation through human clinical trials to validate these findings.

How it works

Rauwolfia vomitoria's mechanism of action is primarily attributed to its alkaloid content, such as reserpine. These alkaloids can affect neurotransmitter systems, potentially influencing blood pressure and tumor growth. Reserpine is known to deplete catecholamines, impacting the cardiovascular and nervous systems. While specific molecular targets for cancer treatment are not well-defined, the extract's alkaloids are believed to interfere with cancer cell proliferation and stem cell activity. However, detailed data on the absorption and bioavailability of Rauwolfia vomitoria extract remains limited, requiring further research to fully elucidate its pharmacokinetic properties.

Side effects

While Rauwolfia vomitoria has a history of traditional use, modern clinical data on its long-term safety is limited. Common side effects are not well-documented in contemporary studies, but potential adverse effects may include gastrointestinal disturbances, typical of herbal extracts. Drug interactions are a concern, particularly with antihypertensive medications or other drugs affecting the nervous system. Rauwolfia vomitoria is contraindicated in pregnancy and breastfeeding due to a lack of safety data. Caution is advised for patients with cardiovascular conditions or those taking medications for hypertension. Due to the limited data, it is essential to consult with a healthcare professional before using Rauwolfia vomitoria extract to assess potential risks and interactions.

Dosage

Due to limited modern research, a minimum effective dose, optimal dosage ranges, and maximum safe dose for Rauwolfia vomitoria are not well-defined. Dosage recommendations vary widely based on traditional use and experimental conditions. Typically, it is used as a root bark extract. There is limited data on absorption factors. Vitamin E may enhance hematological effects when co-administered. Caution is advised due to potential interactions with other medications. Given the lack of comprehensive data, it is crucial to consult with a healthcare provider to determine a safe and appropriate dosage, considering individual health status and potential interactions.

FAQs

Is Rauwolfia vomitoria safe?

While traditionally used, modern safety data is limited, especially regarding long-term use. Consult a healthcare professional before use.

How should I take Rauwolfia vomitoria?

No specific guidelines are available. Consult with a healthcare provider for personalized advice.

What are the expected results?

Potential benefits include cancer treatment and hematological improvements, but more research is needed to confirm these effects.

Is Rauwolfia vomitoria a proven treatment for hypertension?

Despite historical use, it is not a proven treatment for hypertension in modern medicine. Consult a healthcare professional for appropriate treatments.

Research Sources

https://journals.sagepub.com/doi/abs/10.1177/1534735414532010 – This study investigates the antitumor activities of Rauwolfia vomitoria extract. The research demonstrates that the extract inhibits pancreatic cancer cell growth and synergizes with gemcitabine, suggesting potential benefits in cancer treatment. However, the study is limited by the absence of human clinical trials, necessitating further validation.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3296325/ – This animal study explores the effects of Rauwolfia vomitoria in combination with vitamin E on hematological indices. The findings suggest that the combination may enhance hematological parameters. However, the study's applicability to humans is limited, and human trials are needed to confirm these effects.
https://journals.sagepub.com/doi/full/10.1177/1534735414532010 – This research provides a full report on the antitumor activities of Rauwolfia vomitoria extract, detailing its inhibitory effects on pancreatic cancer cell growth and synergistic interaction with gemcitabine. The study highlights the potential of the extract in cancer treatment but emphasizes the need for further clinical validation through human trials.
https://restorativemedicine.org/library/monographs/african-snake-root/ – This monograph provides a general overview of African Snake Root (Rauwolfia vomitoria), covering its traditional uses and potential medicinal properties. It serves as a resource for understanding the plant's historical applications and emerging research areas, though it does not present original research findings.
https://pubmed.ncbi.nlm.nih.gov/30272287/ – This study focuses on the inhibitory effects of Rauwolfia vomitoria on pancreatic cancer stem cells. The research demonstrates that the extract can inhibit these cells, suggesting a potential avenue for cancer treatment. However, the study is limited by the absence of human clinical trials, requiring further research to validate these findings in humans.