Red Atractylodes Rhizome Extract
Also known as: Atractylodes lancea (Thunb.) DC., Atractylodes chinensis (DC.) Koidz., Atractylodes macrocephala Koidz., Red Atractylodes Rhizome, Atractylodis Rhizoma, Atractylodes Rhizome, Atractylodes lancea
Overview
Atractylodis Rhizoma is derived from the rhizomes of various *Atractylodes* species, including *Atractylodes lancea* and *Atractylodes chinensis*. This herbal extract has been traditionally utilized in East Asian medicine for its diverse health benefits, particularly as a diuretic and stomachic. Prominently used in treating conditions like rheumatic diseases, digestive disorders, and influenza, this herb contains bioactive compounds such as sesquiterpenoids and alkynes. Although it has a long history of use, modern research is still uncovering its molecular mechanisms and efficacy in contemporary contexts, with evidence available but needing more high-quality studies to confirm its therapeutic effects.
Benefits
Atractylodes Rhizome has several endorsed benefits, with antiviral, anti-inflammatory, and gastrointestinal impacts noted in research. Atractylon, a key sesquiterpene lactone in the plant, has displayed significant antiviral activity against influenza viruses, with one in vitro study confirming this effect. Additionally, there are indications of the extract improving intestinal microbiota composition and showing antioxidant properties. However, the data on exact effect sizes and clinical significance in human populations remains limited, suggesting a need for further exploration, particularly in specific demographics or conditions. Evidence consistency is variable and emphasizes the traditional usage rather than robust clinical studies.
How it works
The mechanisms behind Atractylodes Rhizome's effects may involve several biological pathways, particularly its antiviral properties, which are thought to interfere with viral adsorption or replication, potentially through the activation of immune pathways like Toll-like receptor 7 (TLR7). The gastrointestinal benefits are likely linked to modulation of gut microbiota, promoting a healthier balance and supporting digestive functions. However, detailed studies on absorption and bioavailability are currently lacking, which could illuminate these mechanisms further.
Side effects
Overall, Atractylodes Rhizome is considered safe based on traditional usage, yet modern safety profiles are not well-established. There are reports of potential gastrointestinal upset, though common and serious side effects have not been well-documented. The herb may interact with other medications, particularly those that influence the immune system or gastrointestinal function. Pregnant and breastfeeding individuals should avoid its use due to insufficient evidence on safety in these populations. Additionally, individuals with compromised immune systems should exercise caution, underscoring the importance of monitoring in susceptible groups.
Dosage
Recommended dosage ranges for Atractylodes Rhizome vary broadly, as traditional use does not define a minimum effective dose or maximum safe limits. Practitioners often derive dosages based on extract forms, which may differ significantly. The optimal dosage for various applications remains undetermined, and there is a need for standardized formulations to ensure consistent dosing. Currently, no specific timing considerations or cofactors are identified, highlighting a gap in ingestion protocol studies.
FAQs
Is Atractylodes Rhizome safe to use?
Generally, it is considered safe, but modern safety data are limited; consult a healthcare provider before use.
What dosage should I take?
Dosages vary widely; traditional use has not established standard dosages, and professional guidance is recommended.
Can I use Atractylodes Rhizome while pregnant?
No, it is advised to avoid use during pregnancy and breastfeeding due to insufficient safety data.
Are there specific side effects?
Some gastrointestinal upset has been reported, but common side effects are not well-documented.
Does Atractylodes Rhizome interact with medications?
Yes, it may interact with other medications, notably those impacting gastrointestinal or immune functions.
Research Sources
- https://www.spandidos-publications.com/10.3892/mmr.2016.5713 – This study provides evidence of Atractylodes Rhizoma extracts, particularly atractylon, exhibiting significant antiviral activity against influenza viruses based on in vitro analysis, highlighting its potential therapeutic application.
- https://www.mdpi.com/1420-3049/17/11/13457 – The research explores Rhizoma Atractylodes macrocephala polysaccharides and their effect on gut microbiota regulation in an animal model, supporting claims of gastrointestinal benefits while acknowledging the need for human studies.
- https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2022.1102605/full – This comprehensive review details the phytochemistry and pharmacology associated with Atractylodis Rhizoma, emphasizing its traditional uses, potential benefits, and the imperative for further research to validate clinical efficacy.
- https://pubmed.ncbi.nlm.nih.gov/32987126/ – This publication outlines the traditional uses of Atractylodes spp. and notes significant gaps in the scientific understanding of its pharmacological properties, calling for a thorough investigation of its effective compounds.
- https://www.researchgate.net/publication/344424295_Atractylodis_Rhizoma_A_review_of_its_traditional_uses_phytochemistry_pharmacology_toxicology_and_quality_control – A systematic review covering Atractylodis Rhizoma discusses its historical context, chemical makeup, suspected therapeutic benefits, and necessary quality control measures, stressing the importance of good manufacturing practices.
